Tractographic and Microstructural Analysis of the Dentato-Rubro-Thalamo-Cortical Tracts in Children Using Diffusion MRI.

التفاصيل البيبلوغرافية
العنوان:	Tractographic and Microstructural Analysis of the Dentato-Rubro-Thalamo-Cortical Tracts in Children Using Diffusion MRI.
المؤلفون:	Toescu SM; Developmental Imaging and Biophysics Section, UCL-GOS Institute of Child Health, London WC1N 1EH, UK.; Department of Neurosurgery, Great Ormond Street Hospital, London WC1N 3JH, UK., Hales PW; Developmental Imaging and Biophysics Section, UCL-GOS Institute of Child Health, London WC1N 1EH, UK., Kaden E; Developmental Imaging and Biophysics Section, UCL-GOS Institute of Child Health, London WC1N 1EH, UK.; Centre for Medical Image Computing, University College London, London WC1V 6LJ, UK., Lacerda LM; Developmental Imaging and Biophysics Section, UCL-GOS Institute of Child Health, London WC1N 1EH, UK., Aquilina K; Department of Neurosurgery, Great Ormond Street Hospital, London WC1N 3JH, UK., Clark CA; Developmental Imaging and Biophysics Section, UCL-GOS Institute of Child Health, London WC1N 1EH, UK.
المصدر:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2021 Mar 31; Vol. 31 (5), pp. 2595-2609.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: Oxford University Press Country of Publication: United States NLM ID: 9110718 Publication Model: Print Cited Medium: Internet ISSN: 1460-2199 (Electronic) Linking ISSN: 10473211 NLM ISO Abbreviation: Cereb Cortex Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: New York, NY : Oxford University Press, c1991-
مواضيع طبية MeSH:	Cerebellar Nuclei/diagnostic imaging , Cerebral Cortex/diagnostic imaging , Red Nucleus/diagnostic imaging , Thalamus/diagnostic imaging, Adolescent ; Adult ; Cerebellar Diseases ; Child ; Diffusion Tensor Imaging ; Female ; Healthy Volunteers ; Humans ; Male ; Motor Cortex/diagnostic imaging ; Mutism ; Neural Pathways/diagnostic imaging ; Neurosurgical Procedures ; Postoperative Complications ; Prefrontal Cortex/diagnostic imaging ; Young Adult
مستخلص:	The dentato-rubro-thalamo-cortical tract (DRTC) is the main outflow pathway of the cerebellum, contributing to a finely balanced corticocerebellar loop involved in cognitive and sensorimotor functions. Damage to the DRTC has been implicated in cerebellar mutism syndrome seen in up to 25% of children after cerebellar tumor resection. Multi-shell diffusion MRI (dMRI) combined with quantitative constrained spherical deconvolution tractography and multi-compartment spherical mean technique modeling was used to explore the frontocerebellar connections and microstructural signature of the DRTC in 30 healthy children. The highest density of DRTC connections were to the precentral (M1) and superior frontal gyri (F1), and from cerebellar lobules I-IV and IX. The first evidence of a topographic organization of anterograde projections to the frontal cortex at the level of the superior cerebellar peduncle (SCP) is demonstrated, with streamlines terminating in F1 lying dorsomedially in the SCP compared to those terminating in M1. The orientation dispersion entropy of DRTC regions appears to exhibit greater contrast than that shown by fractional anisotropy. Analysis of a separate reproducibility cohort demonstrates good consistency in the dMRI metrics described. These novel anatomical insights into this well-studied pathway may prove to be of clinical relevance in the surgical resection of cerebellar tumors. (© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.)
فهرسة مساهمة:	Keywords: cerebellar mutism syndrome; constrained spherical deconvolution; dentato-rubro-thalamo-cortical tract; spherical mean technique; tractography
تواريخ الأحداث:	Date Created: 20201218 Date Completed: 20220214 Latest Revision: 20220214
رمز التحديث:	20240628
DOI:	10.1093/cercor/bhaa377
PMID:	33338201
قاعدة البيانات:	MEDLINE

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تدمد:	1460-2199
DOI:	10.1093/cercor/bhaa377