دورية أكاديمية
Design of 18 nm Doxorubicin-Loaded 3-Helix Micelles: Cellular Uptake and Cytotoxicity in Patient-Derived GBM6 Cells.
العنوان: | Design of 18 nm Doxorubicin-Loaded 3-Helix Micelles: Cellular Uptake and Cytotoxicity in Patient-Derived GBM6 Cells. |
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المؤلفون: | Jung BT; Department of Materials Science and Engineering, University of California, Berkeley, Berkeley, California 94720, United States., Jung K; Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, United States., Lim M; UCB-UCSF Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, California 94720, United States., Li M; Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, United States., Santos R; Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94158, United States., Ozawa T; Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94158, United States., Xu T; Department of Materials Science and Engineering, University of California, Berkeley, Berkeley, California 94720, United States.; Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, United States.; Material Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States. |
المصدر: | ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2021 Jan 11; Vol. 7 (1), pp. 196-206. Date of Electronic Publication: 2020 Dec 18. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101654670 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-9878 (Electronic) Linking ISSN: 23739878 NLM ISO Abbreviation: ACS Biomater Sci Eng Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, [2015]- |
مواضيع طبية MeSH: | Antineoplastic Agents* , Micelles*, Biological Transport ; Doxorubicin ; Humans ; Tissue Distribution |
مستخلص: | The fate of nanocarrier materials at the cellular level constitutes a critical checkpoint in the development of effective nanomedicines, determining whether tissue level accumulation results in therapeutic benefit. The cytotoxicity and cell internalization of ∼18 nm 3-helix micelle (3HM) loaded with doxorubicin (DOX) were analyzed in patient-derived glioblastoma (GBM) cells in vitro . The half-maximal inhibitory concentration (IC |
فهرسة مساهمة: | Keywords: PEGylation; cellular uptake; glioblastoma; nano−bio interface; patient-derived xenograft; peptide amphiphiles |
المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Micelles) 80168379AG (Doxorubicin) |
تواريخ الأحداث: | Date Created: 20201218 Date Completed: 20210514 Latest Revision: 20210514 |
رمز التحديث: | 20231215 |
DOI: | 10.1021/acsbiomaterials.0c01639 |
PMID: | 33338381 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2373-9878 |
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DOI: | 10.1021/acsbiomaterials.0c01639 |