دورية أكاديمية
The gene profile of Enterobacteriaceae virulence factors in relation to bacteriuria levels between the acute episodes of recurrent uncomplicated lower urinary tract infection.
| العنوان: | The gene profile of Enterobacteriaceae virulence factors in relation to bacteriuria levels between the acute episodes of recurrent uncomplicated lower urinary tract infection. |
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| المؤلفون: | Naboka YL; Department of Microbiology No. 1, Rostov State Medical University Hospital, Rostov-on-Don, Russia., Mavzyutov AR; Department of Fundamental and Applied Microbiology, Bashkir State Medical University, Ufa, Russia., Kogan MI; Department of Urology, Rostov State Medical University Hospital, Rostov-on-Don, Russia., Gudima IA; Department of Microbiology No. 1, Rostov State Medical University Hospital, Rostov-on-Don, Russia., Dzhalagoniya KT; Department of Microbiology No. 1, Rostov State Medical University Hospital, Rostov-on-Don, Russia., Ivanov SN; Department of Urology, Rostov State Medical University Hospital, Rostov-on-Don, Russia., Naber KG; Department of Urology, Technical University of Munich, Munich, Germany. |
| المصدر: | Expert review of anti-infective therapy [Expert Rev Anti Infect Ther] 2021 Aug; Vol. 19 (8), pp. 1061-1066. Date of Electronic Publication: 2021 Jan 04. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101181284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8336 (Electronic) Linking ISSN: 14787210 NLM ISO Abbreviation: Expert Rev Anti Infect Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Abingdon, Oxford : Taylor & Francis Original Publication: London : Future Drugs Ltd. |
| مواضيع طبية MeSH: | Bacteriuria/*microbiology , Enterobacteriaceae/*isolation & purification , Genes, Bacterial/*genetics , Urinary Tract Infections/*microbiology, Adolescent ; Adult ; Bacteriuria/epidemiology ; Enterobacteriaceae/genetics ; Female ; Humans ; Middle Aged ; Premenopause ; Recurrence ; Urinary Tract Infections/epidemiology ; Virulence Factors ; Young Adult |
| مستخلص: | Objectives: The pathogenic potential of uropathogens isolated between acute episodes of recurrent lower urinary tract infection (rLUTI) is studied insufficiently. The objectives were to determine the spectrum of virulence genes of Enterobacteriaceae cultured between acute episodes of rLUTI at various levels of bacteriuria. Methods: Bacteriological examinations of 169 premenopausal women's midstream urine with rLUTI were performed between acute episodes of UTI. Sixty-two strains of Enterobacteriaceae at concentrations 10 2 -10 8 CFU/ml were analyzed for the presence of papA, papE/F, papGII, afa, bmaE, iutA, feoB, fyuA, kpsMTII, and usp virulence factors genes' (VFGs) fragments. Results: In all strains VFGs were found with numbers from 1 to 10. Four VFGs were found at all levels of bacteriuria (from 10 2 to 10 7-8 ) in most strains (>50%): papGII, feoB, fyuA, usp. In total, 28 significant Pearson contingency coefficient (PCC) were determined. Each of the genes, papA, papE/F, usp, was found more often in uropathogens from patients with a higher level of leukocyturia. Conclusions: The inter-episode period in rLUTI is associated with varying levels of bacteriuria of enterobacteria. Since enterobacteria virulent potential could be determined at all levels of bacteriuria, there is at all levels of bacteriuria a potential risk for recurrence of LUTI. |
| فهرسة مساهمة: | Keywords: Recurrent urinary tract infection; bacteriuria; enterobacteriaceae; uropathogenic Escherichia coli; virulence factor genes |
| المشرفين على المادة: | 0 (Virulence Factors) |
| تواريخ الأحداث: | Date Created: 20201218 Date Completed: 20211019 Latest Revision: 20211019 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/14787210.2021.1866986 |
| PMID: | 33338384 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1744-8336 |
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| DOI: | 10.1080/14787210.2021.1866986 |