دورية أكاديمية
Transcranial direct current stimulation for fatigue in patients with Sjogren's syndrome: A randomized, double-blind pilot study.
| العنوان: | Transcranial direct current stimulation for fatigue in patients with Sjogren's syndrome: A randomized, double-blind pilot study. |
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| المؤلفون: | Pinto ACPN; Evidence-Based Health Program, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil; Fulbright Scholar at University of Pittsburgh, PA, USA; Biological and Health Sciences Department, Universidade Federal Do Amapa (UNIFAP), AP, Brazil., Piva SR; Department of Physical Therapy, School of Health and Rehabilitation Science, University of Pittsburgh. Pittsburgh, PA, USA. Electronic address: spiva@pitt.edu., Vieira AGDS; Evidence-Based Health Program, EPM, UNIFESP, São Paulo, SP, Brazil., Gomes SGCN; Evidence-Based Health Program, EPM, UNIFESP, São Paulo, SP, Brazil., Rocha AP; Evidence-Based Health Program, EPM, UNIFESP, São Paulo, SP, Brazil., Tavares DRB; Evidence-Based Health Program, EPM, UNIFESP, São Paulo, SP, Brazil., Santana MVA; Evidence-Based Health Program, EPM, UNIFESP, São Paulo, SP, Brazil., Carlesso C; Department of Physical Therapy, School of Health and Rehabilitation Science, University of Pittsburgh. Pittsburgh, PA, USA., Andriolo A; Department of Medicine, EPM - UNIFESP, São Paulo, SP, Brazil., Santos FC; Department of Geriatrics and Gerontology, EPM - UNIFESP, Brazil., Fregni F; Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, USA., Trevisani VFM; Rheumatologist. Discipline of Emergency and Evidence-Based Medicine, EPM - UNIFESP, São Paulo, SP, Brazil. |
| المصدر: | Brain stimulation [Brain Stimul] 2021 Jan-Feb; Vol. 14 (1), pp. 141-151. Date of Electronic Publication: 2020 Dec 17. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101465726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4754 (Electronic) Linking ISSN: 18764754 NLM ISO Abbreviation: Brain Stimul Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Elsevier |
| مواضيع طبية MeSH: | Sjogren's Syndrome*/complications , Sjogren's Syndrome*/therapy , Transcranial Direct Current Stimulation*, Double-Blind Method ; Fatigue/etiology ; Fatigue/therapy ; Female ; Humans ; Pilot Projects |
| مستخلص: | Background: Transcranial direct-current stimulation (tDCS) has shown promise to decrease fatigue. However, it has never been examined in primary Sjogren Syndrome (pSS). Objective: To assess the effect of a tDCS protocol on fatigue in patients with pSS. Methods: This is a parallel, double-blind pilot study (NCT04119128). Women aged 18-65 years, with pSS, on stable pharmacological therapy, with complaints of fatigue for at least three months, and with scores >5 on Fatigue Severity Scale (FSS) were included. We randomized 36 participants to receive five consecutive or sham tDCS sessions, with an intensity of 2 mA, for 20 min/day. Results: After five tDCS sessions, fatigue severity assessed by the FSS (primary outcome) demonstrated a mean group difference of -0.85 [95% confidence interval (CI) -1.57, -0.13; effect size 0.80] favouring the active group. The active group presented significantly greater reductions in fatigue as measured by the EULAR Sjögren's Syndrome Patient Reported Index after five tDCS sessions [mean group difference: 1.40; 95%CI -2.33, -0.48; effect size 1.04]. Although there were no between-group differences in the secondary outcomes of sleep, mood and anxiety, within-group comparisons evidenced a small but significant difference in the active group for pain and sleep. There were no significant cortisol changes. All reported adverse events were mild and transitory. Conclusion: tDCS seems to be safe and reduce fatigue in pSS. A differential effect on pain and sleep may underlie its effects. Further studies are needed to optimise tDCS treatment strategies in pSS. Competing Interests: Declaration of competing interest None. (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Fatigue; Sjogren’s syndrome; Transcranial direct current stimulation |
| تواريخ الأحداث: | Date Created: 20201219 Date Completed: 20211001 Latest Revision: 20211001 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.brs.2020.12.004 |
| PMID: | 33340767 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1876-4754 |
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| DOI: | 10.1016/j.brs.2020.12.004 |