دورية أكاديمية
أعرض في EDS

Benznidazole: Hero or villain of cellular immune response in chronic Chagas disease patients?

التفاصيل البيبلوغرافية
العنوان: Benznidazole: Hero or villain of cellular immune response in chronic Chagas disease patients?
المؤلفون: Soares AKA; Instituto Aggeu Magalhães - IAM/Fiocruz, Recife, PE, Brazil; Fundação Altino Ventura - FAV, Recife, PE, Brazil., Neves PAF; Instituto Aggeu Magalhães - IAM/Fiocruz, Recife, PE, Brazil; Hospital das Clínicas - HC/UFPE, Recife, PE, Brazil., Nascimento AV; Instituto Aggeu Magalhães - IAM/Fiocruz, Recife, PE, Brazil., Esmeraldo AAM; Instituto Aggeu Magalhães - IAM/Fiocruz, Recife, PE, Brazil., Moreira LR; Instituto Aggeu Magalhães - IAM/Fiocruz, Recife, PE, Brazil., Higino TMM; Instituto Aggeu Magalhães - IAM/Fiocruz, Recife, PE, Brazil; Fundação Altino Ventura - FAV, Recife, PE, Brazil., C B Q Figueiredo R; Instituto Aggeu Magalhães - IAM/Fiocruz, Recife, PE, Brazil., G A M Cavalcanti M; Ambulatório de doença de Chagas e Insuficiência Cardíaca do Pronto Socorro Cardiológico de Pernambuco (PROCAPE) - Universidade de Pernambuco (UPE), Recife, PE, Brazil., Martins SM; Ambulatório de doença de Chagas e Insuficiência Cardíaca do Pronto Socorro Cardiológico de Pernambuco (PROCAPE) - Universidade de Pernambuco (UPE), Recife, PE, Brazil., Carrazone C; Ambulatório de doença de Chagas e Insuficiência Cardíaca do Pronto Socorro Cardiológico de Pernambuco (PROCAPE) - Universidade de Pernambuco (UPE), Recife, PE, Brazil., Júnior WO; Ambulatório de doença de Chagas e Insuficiência Cardíaca do Pronto Socorro Cardiológico de Pernambuco (PROCAPE) - Universidade de Pernambuco (UPE), Recife, PE, Brazil., Gomes YM; Instituto Aggeu Magalhães - IAM/Fiocruz, Recife, PE, Brazil., Lorena VMB; Instituto Aggeu Magalhães - IAM/Fiocruz, Recife, PE, Brazil. Electronic address: lorena@cpqam.fiocruz.br.
المصدر: Immunobiology [Immunobiology] 2021 Jan; Vol. 226 (1), pp. 152046. Date of Electronic Publication: 2020 Dec 04.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8002742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3279 (Electronic) Linking ISSN: 01712985 NLM ISO Abbreviation: Immunobiology Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005->: Amsterdam : Elsevier
Original Publication: Stuttgart ; New York, Fischer.
مواضيع طبية MeSH: Chagas Disease/*immunology , Leukocytes, Mononuclear/*immunology , Nitroimidazoles/*pharmacology , Trypanocidal Agents/*pharmacology , Trypanosoma cruzi/*immunology, Antigen Presentation ; B7-1 Antigen/metabolism ; Cells, Cultured ; Chagas Disease/drug therapy ; Chronic Disease ; HLA-DR Antigens/metabolism ; Humans ; Immunity, Cellular ; Leukocytes, Mononuclear/parasitology ; Lymphocyte Activation ; Macrophage Activation ; Phagocytosis
مستخلص: Although the treatment of chronic Chagas disease (CCD) patients with Benznidazole (Bz) is still controversial, its use may prevent or delay the progression of the disease to the most severe forms. One of the main factors that can influence the effectiveness of the treatment is the possible cooperation between drug effect and the host immune response. Herein, we evaluated the immune response of peripheral blood mononuclear cells (PBMCs) infected with Trypanosoma cruzi and submitted to Bz treatment. Blood samples of CCD patients (n = 7) and non-infected individuals (n = 6) were drawn to obtain PBMCs. After cell culture, the supernatants were harvested and stored, and the cell analyzed by flow cytometer. The results showed that Bz positively regulated the molecular process of cell activation (CD80) and antigen presentation (HLA-DR), increased phagocytosis receptor and macrophage activation (CD64), and did not induce an exacerbated immune response. In conclusion, these results highlight the relevance of using Bz that, despite not being a true hero, it is also not a villain, as it presents a wide range of pharmacological/immunological response interactions, important for the immune balance in the clinical progression of CCD.
(Copyright © 2020 Elsevier GmbH. All rights reserved.)
فهرسة مساهمة: Keywords: Benznidazole; Chagas disease; Etiological treatment; Immune response; Innate immunity; Surface receptors; Trypanosoma cruzi
المشرفين على المادة: 0 (B7-1 Antigen)
0 (HLA-DR Antigens)
0 (Nitroimidazoles)
0 (Trypanocidal Agents)
YC42NRJ1ZD (benzonidazole)
تواريخ الأحداث: Date Created: 20201220 Date Completed: 20220124 Latest Revision: 20220124
رمز التحديث: 20240628
DOI: 10.1016/j.imbio.2020.152046
PMID: 33341661
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-3279
DOI:10.1016/j.imbio.2020.152046