دورية أكاديمية
COX-2 Overexpression in Schneiderian Papillomas.
| العنوان: | COX-2 Overexpression in Schneiderian Papillomas. |
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| المؤلفون: | Suh JD; Department of Head and Neck Surgery, University of California, Los Angeles, California., Hur K; Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California.; Department of Otolaryngology-Head and Neck Surgery, Northwestern University, Chicago, Illinois., Ference EH; Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California., Lam DD; Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California., Fong A; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California., Correa AJ; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California., Wrobel B; Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California. |
| المصدر: | Allergy & rhinology (Providence, R.I.) [Allergy Rhinol (Providence)] 2020 Dec 08; Vol. 11, pp. 2152656720973689. Date of Electronic Publication: 2020 Dec 08 (Print Publication: 2020). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publications Country of Publication: United States NLM ID: 101570968 Publication Model: eCollection Cited Medium: Print ISSN: 2152-6575 (Print) Linking ISSN: 21526567 NLM ISO Abbreviation: Allergy Rhinol (Providence) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2018-2022 : Thousand Oaks, CA : SAGE Publications Original Publication: Providence, RI : Oceanside Publications |
| مستخلص: | Background: Schneiderian papillomas (SP) are aggressive sinonasal tumors that occasionally extend into areas that are surgically unresectable. Objective: evaluate the signifcance of cyclo-oxygenase-2 (COX-2) expression in SP. Methods: Immunohistochemistry for COX-2 was performed on SP samples and middle turbinates from chronic rhinosinusitis without nasal polyps controls obtained during surgical resection between 2009-2017. A positive stain was defined as having 10% or more cells exhibiting diffuse immunoreactivity. Comparisons were performed using Fisher Exact tests, t-tests, and ANOVA. Results: The study included 67 tumor samples and 9 controls from two academic institutions. The mean age of the SP group was 55.4 years and 53.2 years in the control group (p = 0.71). Thirty-nine (58.2%) SP patients had previous surgery compared to 1 (11.1%) in the control group (p = 0.01). The most common tumor attachment sites were the maxillary (47.8%) and ethmoid (25.4%) sinuses. Fifteen (22.4%) SP samples stained strongly positive for COX-2 and 24 (35.8%) stained weakly positive compared to no positive stains in the control group (p < 0.01). When stratified by COX-2 intensity, there were no statistically significant differences in gender, smoking history, history of previous sinus surgery, site of attachment, papilloma subtype, or future recurrence between SP samples. Conclusion: COX-2 was overexpressed in 58.2% of SP cases, and strongly positive in 22.4% of cases, compared to no positive staining among controls. No significant differences in COX-2 expression were observed between SP subtypes or recurrent tumors. Further studies are warranted to evaluate COX-2 as a possible therapeutic target in tumors that overexpress the enzyme. Competing Interests: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s) 2020.) |
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| معلومات مُعتمدة: | UL1 TR001855 United States TR NCATS NIH HHS |
| فهرسة مساهمة: | Keywords: COX-2; Schneiderian papilloma; cyclo-oxygenase; inverted papilloma; oncocytic papilloma; sinonasal tumor |
| تواريخ الأحداث: | Date Created: 20201221 Latest Revision: 20220419 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC7731694 |
| DOI: | 10.1177/2152656720973689 |
| PMID: | 33343991 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2152-6575 |
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| DOI: | 10.1177/2152656720973689 |