دورية أكاديمية
Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice.
العنوان: | Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice. |
---|---|
المؤلفون: | Frank K; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America., Abeynaike S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America., Nikzad R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America., Patel RR; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, United States of America., Roberts AJ; Animal Models Core, The Scripps Research Institute, La Jolla, CA, United States of America., Roberto M; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, United States of America., Paust S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America. |
المصدر: | PloS one [PLoS One] 2020 Dec 21; Vol. 15 (12), pp. e0239246. Date of Electronic Publication: 2020 Dec 21 (Print Publication: 2020). |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
مواضيع طبية MeSH: | Alcoholism/*metabolism , Ethanol/*adverse effects , Interferon-gamma/*metabolism , Interleukin-17/*metabolism, Animals ; Cytokines/metabolism ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Spleen/drug effects ; Spleen/metabolism |
مستخلص: | Alcohol use disorder (AUD) is a chronic relapsing disorder characterized by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences. AUD is associated with a variety of physiological changes and is a substantial risk factor for numerous diseases. We aimed to characterize systemic alterations in immune responses using a well-established mouse model of chronic intermittent alcohol exposure to induce alcohol dependence. We exposed mice to chronic intermittent ethanol vapor for 4 weeks and analyzed the expression of cytokines IFN-γ, IL-4, IL-10, IL-12 and IL-17 by different immune cells in the blood, spleen and liver of alcohol dependent and non-dependent control mice through multiparametric flow cytometry. We found increases in IFN-γ and IL-17 expression in a cell type- and organ-specific manner. Often, B cells and neutrophils were primary contributors to increased IFN-γ and IL-17 levels while other cell types played a secondary role. We conclude that chronic alcohol exposure promotes systemic pro-inflammatory IFN-γ and IL-17 responses in mice. These responses are likely important in the development of alcohol-related diseases, but further characterization is necessary to understand the initiation and effects of systemic inflammatory responses to chronic alcohol exposure. Competing Interests: The authors have declared that no competing interests exist. |
References: | Curr Pathobiol Rep. 2016 Mar;4(1):27-35. (PMID: 27239399) Clin Liver Dis. 2016 Aug;20(3):595-606. (PMID: 27373619) PLoS One. 2013 Dec 05;8(12):e82580. (PMID: 24340045) Microb Pathog. 2003 Sep;35(3):119-24. (PMID: 12927519) Biomolecules. 2017 Aug 14;7(3):. (PMID: 28805741) Clin Liver Dis (Hoboken). 2019 May 31;13(5):136-139. (PMID: 31236261) Alcohol Clin Exp Res. 1993 Jun;17(3):561-5. (PMID: 8333585) Cytometry B Clin Cytom. 2007 Sep;72(5):408-15. (PMID: 17266151) Am J Physiol Gastrointest Liver Physiol. 2002 Jan;282(1):G6-15. (PMID: 11751152) PLoS One. 2012;7(11):e49008. (PMID: 23155443) Brain Behav Immun. 2019 Jan;75:208-219. (PMID: 30791967) J Immunol. 2010 Feb 15;184(4):1776-83. (PMID: 20083665) Am J Physiol Gastrointest Liver Physiol. 2001 Jun;280(6):G1289-95. (PMID: 11352823) Int Immunol. 1993 Nov;5(11):1383-92. (PMID: 8260452) J Immunol. 2005 Jun 1;174(11):6781-90. (PMID: 15905519) Ann Neurol. 2009 Sep;66(3):390-402. (PMID: 19810097) eNeuro. 2020 Mar 5;7(2):. (PMID: 32041742) Nat Immunol. 2005 Nov;6(11):1133-41. (PMID: 16200068) Cell Res. 2014 Feb;24(2):161-76. (PMID: 24296781) Clin Exp Allergy. 1995 Aug;25(8):756-64. (PMID: 7584688) Neuropharmacology. 2018 May 1;133:470-480. (PMID: 29471053) Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3948-53. (PMID: 9108085) Blood. 2009 Jun 25;113(26):6611-8. (PMID: 19395673) J Leukoc Biol. 2005 Nov;78(5):1070-80. (PMID: 16260584) Alcohol Clin Exp Res. 2006 Apr;30(4):720-30. (PMID: 16573591) Alcohol Clin Exp Res. 1999 Aug;23(8):1306-11. (PMID: 10470972) J Clin Invest. 1985 May;75(5):1488-95. (PMID: 3923038) Alcohol Clin Exp Res. 2009 Mar;33(3):419-27. (PMID: 19120059) J Leukoc Biol. 2002 Aug;72(2):373-81. (PMID: 12149429) Alcohol Clin Exp Res. 2001 Aug;25(8):1198-205. (PMID: 11505051) J Exp Med. 1998 Oct 19;188(8):1453-64. (PMID: 9782122) Infect Immun. 1997 Dec;65(12):5149-56. (PMID: 9393809) Nat Immunol. 2014 Dec;15(12):1181-9. (PMID: 25306126) World J Gastroenterol. 2014 Oct 28;20(40):14652-9. (PMID: 25356028) J Biol Chem. 2002 Apr 26;277(17):14777-85. (PMID: 11856733) Eur J Immunol. 2001 Dec;31(12):3460-8. (PMID: 11745365) Alcohol Clin Exp Res. 2006 Sep;30(9):1615-23. (PMID: 16930225) Clin Vaccine Immunol. 2012 May;19(5):746-51. (PMID: 22461525) J Immunol. 2009 Jun 1;182(11):7069-73. (PMID: 19454704) J Leukoc Biol. 2002 Dec;72(6):1109-16. (PMID: 12488491) JCI Insight. 2020 Feb 13;5(3):. (PMID: 32051339) Alcohol. 2012 Dec;46(8):715-25. (PMID: 22960051) Alcohol Clin Exp Res. 2004 Dec;28(12):1829-38. (PMID: 15608599) Neuropharmacology. 2016 Aug;107:1-8. (PMID: 26946429) Hepatology. 1997 Jun;25(6):1418-24. (PMID: 9185762) J Hepatol. 2000 Apr;32(4):579-86. (PMID: 10782906) Clin Exp Immunol. 1996 Feb;103(2):304-10. (PMID: 8565316) Hepatology. 1991 Feb;13(2):267-76. (PMID: 1995437) Biol Psychiatry. 2020 Dec 15;88(12):910-921. (PMID: 32680583) J Immunol. 2010 Jul 1;185(1):679-87. (PMID: 20511558) J Exp Med. 1993 Apr 1;177(4):1199-204. (PMID: 8096238) J Neurosci. 2016 Oct 19;36(42):10729-10741. (PMID: 27798128) Toxicol Appl Pharmacol. 2015 Jan 15;282(2):139-50. (PMID: 25499027) Immunity. 2004 Oct;21(4):467-76. (PMID: 15485625) Hepatology. 2009 Feb;49(2):646-57. (PMID: 19177575) Alcohol Clin Exp Res. 2001 Aug;25(8):1221-30. (PMID: 11505054) Immunity. 2006 Dec;25(6):941-52. (PMID: 17137799) Alcohol Alcohol Suppl. 1993;1B:53-7. (PMID: 8003129) Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10711-6. (PMID: 23754402) EBioMedicine. 2019 May;43:562-575. (PMID: 31060902) Brain Behav Immun. 2019 Nov;82:188-202. (PMID: 31437534) J Immunol. 1997 Oct 1;159(7):3490-7. (PMID: 9317148) Nat Immunol. 2013 May;14(5):514-22. (PMID: 23563688) |
معلومات مُعتمدة: | R01 AA027700 United States AA NIAAA NIH HHS; U01 AA013498 United States AA NIAAA NIH HHS; R01 AA016985 United States AA NIAAA NIH HHS; F32 AA026765 United States AA NIAAA NIH HHS; T32 AA007456 United States AA NIAAA NIH HHS; R01 AA017447 United States AA NIAAA NIH HHS; P60 AA006420 United States AA NIAAA NIH HHS; R01 AA015566 United States AA NIAAA NIH HHS; R01 AA021491 United States AA NIAAA NIH HHS |
المشرفين على المادة: | 0 (Cytokines) 0 (Il17a protein, mouse) 0 (Interleukin-17) 3K9958V90M (Ethanol) 82115-62-6 (Interferon-gamma) |
تواريخ الأحداث: | Date Created: 20201221 Date Completed: 20210111 Latest Revision: 20220421 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC7751976 |
DOI: | 10.1371/journal.pone.0239246 |
PMID: | 33347446 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1932-6203 |
---|---|
DOI: | 10.1371/journal.pone.0239246 |