دورية أكاديمية
Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice.
| العنوان: | Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice. |
|---|---|
| المؤلفون: | Frank K; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America., Abeynaike S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America., Nikzad R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America., Patel RR; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, United States of America., Roberts AJ; Animal Models Core, The Scripps Research Institute, La Jolla, CA, United States of America., Roberto M; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, United States of America., Paust S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America. |
| المصدر: | PloS one [PLoS One] 2020 Dec 21; Vol. 15 (12), pp. e0239246. Date of Electronic Publication: 2020 Dec 21 (Print Publication: 2020). |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
| مواضيع طبية MeSH: | Alcoholism/*metabolism , Ethanol/*adverse effects , Interferon-gamma/*metabolism , Interleukin-17/*metabolism, Animals ; Cytokines/metabolism ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Spleen/drug effects ; Spleen/metabolism |
| مستخلص: | Alcohol use disorder (AUD) is a chronic relapsing disorder characterized by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences. AUD is associated with a variety of physiological changes and is a substantial risk factor for numerous diseases. We aimed to characterize systemic alterations in immune responses using a well-established mouse model of chronic intermittent alcohol exposure to induce alcohol dependence. We exposed mice to chronic intermittent ethanol vapor for 4 weeks and analyzed the expression of cytokines IFN-γ, IL-4, IL-10, IL-12 and IL-17 by different immune cells in the blood, spleen and liver of alcohol dependent and non-dependent control mice through multiparametric flow cytometry. We found increases in IFN-γ and IL-17 expression in a cell type- and organ-specific manner. Often, B cells and neutrophils were primary contributors to increased IFN-γ and IL-17 levels while other cell types played a secondary role. We conclude that chronic alcohol exposure promotes systemic pro-inflammatory IFN-γ and IL-17 responses in mice. These responses are likely important in the development of alcohol-related diseases, but further characterization is necessary to understand the initiation and effects of systemic inflammatory responses to chronic alcohol exposure. Competing Interests: The authors have declared that no competing interests exist. |
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| معلومات مُعتمدة: | R01 AA027700 United States AA NIAAA NIH HHS; U01 AA013498 United States AA NIAAA NIH HHS; R01 AA016985 United States AA NIAAA NIH HHS; F32 AA026765 United States AA NIAAA NIH HHS; T32 AA007456 United States AA NIAAA NIH HHS; R01 AA017447 United States AA NIAAA NIH HHS; P60 AA006420 United States AA NIAAA NIH HHS; R01 AA015566 United States AA NIAAA NIH HHS; R01 AA021491 United States AA NIAAA NIH HHS |
| المشرفين على المادة: | 0 (Cytokines) 0 (Il17a protein, mouse) 0 (Interleukin-17) 3K9958V90M (Ethanol) 82115-62-6 (Interferon-gamma) |
| تواريخ الأحداث: | Date Created: 20201221 Date Completed: 20210111 Latest Revision: 20220421 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7751976 |
| DOI: | 10.1371/journal.pone.0239246 |
| PMID: | 33347446 |
| قاعدة البيانات: | MEDLINE |
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