دورية أكاديمية
Tranilast ameliorated subchronic silver nanoparticles-induced cerebral toxicity in rats: Effect on TLR4/NLRP3 and Nrf-2.
| العنوان: | Tranilast ameliorated subchronic silver nanoparticles-induced cerebral toxicity in rats: Effect on TLR4/NLRP3 and Nrf-2. |
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| المؤلفون: | Fahmy EK; Medical Physiology Department, College of Medicine, Zagazig University, Egypt; Medical Physiology Department, Faculty of Medicine, Northern Border University, Saudi Arabia., El-Sherbiny M; Department of Basic Medical Sciences, College of Medicine, Almaarefa University, Ad Diriyah, 13713, Saudi Arabia; Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Said E; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt., Elkattawy HA; Medical Physiology Department, College of Medicine, Zagazig University, Egypt; Department of Basic Medical Sciences, College of Medicine, Almaarefa University, Ad Diriyah, 13713, Saudi Arabia; Zagazig Obesity Management & Research Unit, College of Medicine, Zagazig University, Egypt., Qushawy M; Department of Pharmaceutics, Faculty of Pharmacy, Sinai University, Alarish, North Sinai, 45511, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia., Elsherbiny N; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia; Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. Electronic address: nelsherbiny@ut.edu.sa. |
| المصدر: | Neurotoxicology [Neurotoxicology] 2021 Jan; Vol. 82, pp. 167-176. Date of Electronic Publication: 2020 Dec 23. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7905589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9711 (Electronic) Linking ISSN: 0161813X NLM ISO Abbreviation: Neurotoxicology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2001- : Amsterdam : Elsevier Science Original Publication: Park Forest South, Ill., Pathotox Publishers. |
| مواضيع طبية MeSH: | Cerebrum/*drug effects , Metal Nanoparticles/*toxicity , NF-E2-Related Factor 2/*metabolism , NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism , Neuroprotective Agents/*pharmacology , Silver Compounds/*toxicity , Toll-Like Receptor 4/*metabolism , ortho-Aminobenzoates/*pharmacology, Animals ; Caspase 1/metabolism ; Cerebrum/metabolism ; Cerebrum/pathology ; Creatine Kinase/blood ; Creatine Kinase, BB Form/blood ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley |
| مستخلص: | Silver nanoparticles (AgNPs) are widely applied in various aspects of life. However, recent studies reported their potential toxicity both on environment and human health. The present study aimed to unravel the underlying molecular mechanisms involved in AgNPs-induced brain toxicity. Moreover, chemopreventive effect of tranilast, an analogue of tryptophan metabolite and a mast cell membrane stabilizer was evaluated. Thirty Sprague Dawley rats were enrolled equally into Normal control group, AgNPs-intoxicated group (50 mg/kg, 3 times/week) and tranilast (300 mg/kg, 3 times/week)+AgNPs group. AgNPs administration triggered brain oxidative stress as depicted by reduced Nrf-2 expression, decreased TAC and GSH as well as upregulated brain lipid peroxidation. The apparent brain oxidative damage was accompanied by elevated levels of inflammatory cytokines (IL-1β, IL-6 and TNF-α). Moreover, brain levels of TLR4, NLRP3 and caspase-1 were up-regulated. Additionally, histological study indicated marked cellular injury in cerebrum and cerebellum specimens. This was concomitant with elevated serum CK activity and CK-BB level. On the other hand, tanilast administration remarkably alleviated AgNPs-induced brain toxicity. The present study shed the light on implication of TLR4/NLRP3 axis and NrF2 in AgNPs-induced brain toxicity. In addition, it explored the potential protective effect of tranilast on AgNPs-induced brain injury via antioxidant and anti-inflammatory efficacies. (Copyright © 2020 Elsevier B.V. All rights reserved.) |
| التعليقات: | Retraction in: Neurotoxicology. 2023 Jul;97:158. (PMID: 37316401) |
| فهرسة مساهمة: | Keywords: Cerebral toxicity; NLRP3; Nrf-2; Silver nanoparticles; Tranilast |
| المشرفين على المادة: | 0 (Interleukin-1beta) 0 (Interleukin-6) 0 (NF-E2-Related Factor 2) 0 (NLR Family, Pyrin Domain-Containing 3 Protein) 0 (Neuroprotective Agents) 0 (Nlrp3 protein, rat) 0 (Silver Compounds) 0 (Tlr4 protein, rat) 0 (Toll-Like Receptor 4) 0 (ortho-Aminobenzoates) EC 2.7.3.2 (Creatine Kinase) EC 2.7.3.2 (Creatine Kinase, BB Form) EC 3.4.22.36 (Caspase 1) HVF50SMY6E (tranilast) |
| تواريخ الأحداث: | Date Created: 20201222 Date Completed: 20211029 Latest Revision: 20230717 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.neuro.2020.12.008 |
| PMID: | 33352273 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-9711 |
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| DOI: | 10.1016/j.neuro.2020.12.008 |