دورية أكاديمية
Actin dynamics in the growth cone: a key player in axon regeneration.
| العنوان: | Actin dynamics in the growth cone: a key player in axon regeneration. |
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| المؤلفون: | Leite SC; Institute of Psychiatry and Neurosciences of Paris, INSERM U1266, Université de Paris, 75014 Paris, France., Pinto-Costa R; Nerve Regeneration Group, i3S- Instituto de Investigação e Inovação em Saúde and IBMC- Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal., Sousa MM; Nerve Regeneration Group, i3S- Instituto de Investigação e Inovação em Saúde and IBMC- Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal. Electronic address: msousa@ibmc.up.pt. |
| المصدر: | Current opinion in neurobiology [Curr Opin Neurobiol] 2021 Aug; Vol. 69, pp. 11-18. Date of Electronic Publication: 2020 Dec 25. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Current Biology Country of Publication: England NLM ID: 9111376 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6882 (Electronic) Linking ISSN: 09594388 NLM ISO Abbreviation: Curr Opin Neurobiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London, UK : Current Biology, c1991- |
| مواضيع طبية MeSH: | Actins* , Growth Cones*, Axons ; Nerve Regeneration ; Neurons |
| مستخلص: | Neuronal development, maintenance and function depends on the tight regulation of cytoskeleton organization and dynamics. Following injury, adult central nervous system neurons have a limited ability to regenerate and to recapitulate their robust developmental axon growth. This decreased regenerative capacity is set by their inability to establish regeneration-competent growth cones. Growth cones are actin-enriched structures that regulate axon extension rate and direction. During neuronal development, increasing actin dynamics in the growth cone through the regulation of the activity of specific actin-binding proteins leads to increased axon elongation. Here, we will focus on recent findings showing that enhanced axon regeneration in the adult nervous system can be achieved by promoting actin dynamics, or by decreasing actomyosin contraction in the growth cone. These discoveries underscore the importance of actin organization in the growth cone as a key factor to promote axon (re)growth that should be further explored in the future. (Copyright © 2020 Elsevier Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (Actins) |
| تواريخ الأحداث: | Date Created: 20201228 Date Completed: 20210913 Latest Revision: 20210913 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.conb.2020.11.015 |
| PMID: | 33359956 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-6882 |
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| DOI: | 10.1016/j.conb.2020.11.015 |