دورية أكاديمية
أعرض في EDS

Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study.

التفاصيل البيبلوغرافية
العنوان: Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study.
المؤلفون: Leonhard SE; Department of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands. Electronic address: s.leonhard@erasmusmc.nl., Halstead S; Department of Neurology and Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK., Lant SB; National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Militão de Albuquerque MFP; Department of Collective Health, Institute Aggeu Magalhães (CPqAM), Oswaldo Cruz Foundation (Fiocruz), Recife, Brazil., de Brito CAA; Department of Clinical Medicine, Federal University of Pernambuco, Recife, Brazil., de Albuquerque LBB; Instituto de Medicina Integral Professor Fernando Figueira (IMIP) Recife, Brazil., Ellul MA; National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; The Walton Centre NHS Foundation Trust, Liverpool, UK., de Oliveira França RF; Department of Virology, Institute Aggeu Magalhães (CPqAM), Oswaldo Cruz Foundation (Fiocruz), Recife, Brazil., Gourlay D; Department of Neurology and Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK., Griffiths MJ; National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Alder Hey Children's NHS Foundation Trust, Liverpool, UK., de Miranda Henriques-Souza AM; Department of Paediatrics Neurology, Hospital da Restauração, Recife, Brazil., de Morais Machado MÍ; Department of Paediatrics Neurology, Hospital da Restauração, Recife, Brazil., Medialdea-Carrera R; National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Mehta R; National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., da Paz Melo R; Department of Neurology, Hospital da Restauração, Recife, Brazil., Mesquita SD; Department of Neurology, Hospital da Restauração, Recife, Brazil., Moreira ÁJP; Department of Neurology, Hospital da Restauração, Recife, Brazil., Pena LJ; Department of Virology, Institute Aggeu Magalhães (CPqAM), Oswaldo Cruz Foundation (Fiocruz), Recife, Brazil., Santos ML; Department of Collective Health, Institute Aggeu Magalhães (CPqAM), Oswaldo Cruz Foundation (Fiocruz), Recife, Brazil., Turtle L; National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK., Solomon T; National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; The Walton Centre NHS Foundation Trust, Liverpool, UK., Willison HJ; Department of Neurology and Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK., Jacobs BC; Department of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands., Brito Ferreira ML; Department of Neurology, Hospital da Restauração, Recife, Brazil.
المصدر: Journal of the neurological sciences [J Neurol Sci] 2021 Jan 15; Vol. 420, pp. 117272. Date of Electronic Publication: 2020 Dec 14.
نوع المنشور: Journal Article; Observational Study
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375403 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5883 (Electronic) Linking ISSN: 0022510X NLM ISO Abbreviation: J Neurol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier, <19 ->
مواضيع طبية MeSH: Guillain-Barre Syndrome*/epidemiology , Zika Virus* , Zika Virus Infection*/complications , Zika Virus Infection*/epidemiology, Brazil/epidemiology ; Cohort Studies ; Disease Outbreaks ; Humans
مستخلص: Objective: To determine the clinical phenotype of Guillain-Barré syndrome (GBS) after Zika virus (ZIKV) infection, the anti-glycolipid antibody signature, and the role of other circulating arthropod-borne viruses, we describe a cohort of GBS patients identified during ZIKV and chikungunya virus (CHIKV) outbreaks in Northeast Brazil.
Methods: We prospectively recruited GBS patients from a regional neurology center in Northeast Brazil between December 2014 and February 2017. Serum and CSF were tested for ZIKV, CHIKV, and dengue virus (DENV), by RT-PCR and antibodies, and serum was tested for GBS-associated antibodies to glycolipids.
Results: Seventy-one patients were identified. Forty-eight (68%) had laboratory evidence of a recent arbovirus infection; 25 (52%) ZIKV, 8 (17%) CHIKV, 1 (2%) DENV, and 14 (29%) ZIKV and CHIKV. Most patients with a recent arbovirus infection had motor and sensory symptoms (72%), a demyelinating electrophysiological subtype (67%) and a facial palsy (58%). Patients with a recent infection with ZIKV and CHIKV had a longer hospital admission and more frequent mechanical ventilation compared to the other patients. No specific anti-glycolipid antibody signature was identified in association with arbovirus infection, although significant antibody titres to GM1, GalC, LM1, and GalNAc-GD1a were found infrequently.
Conclusion: A large proportion of cases had laboratory evidence of a recent infection with ZIKV or CHIKV, and recent infection with both viruses was found in almost one third of patients. Most patients with a recent arbovirus infection had a sensorimotor, demyelinating GBS. We did not find a specific anti-glycolipid antibody signature in association with arbovirus-related GBS.
(Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.)
معلومات مُعتمدة: 205228/Z/16/Z United Kingdom WT_ Wellcome Trust; MC_PC_15101 United Kingdom MRC_ Medical Research Council; IS-HPU-1112-10117 United Kingdom DH_ Department of Health; MC_PC_15096 United Kingdom MRC_ Medical Research Council; MC_PC_15105 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: Arbovirus; Chikungunya virus; Guillain-Barré syndrome; Neuroinflammatory disease; Zika virus
تواريخ الأحداث: Date Created: 20201228 Date Completed: 20210514 Latest Revision: 20220129
رمز التحديث: 20221213
DOI: 10.1016/j.jns.2020.117272
PMID: 33360425
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-5883
DOI:10.1016/j.jns.2020.117272