دورية أكاديمية
أعرض في EDS

Risk factors of pain, physical function, and health-related quality of life in elderly people with knee osteoarthritis: A cross-sectional study.

التفاصيل البيبلوغرافية
العنوان: Risk factors of pain, physical function, and health-related quality of life in elderly people with knee osteoarthritis: A cross-sectional study.
المؤلفون: Tavares DRB; Department of Geriatrics and Gerontology, Federal University of São Paulo, São Paulo, SP, Brazil.; Department of Evidence-Based Medicine, Brazilian Cochrane Centre, Federal University of São Paulo, São Paulo, SP, Brazil., Moça Trevisani VF; Department of Evidence-Based Medicine, Brazilian Cochrane Centre, Federal University of São Paulo, São Paulo, SP, Brazil.; Department of Rheumatology, Santo Amaro University, São Paulo, SP, Brazil., Frazao Okazaki JE; Department of Evidence-Based Medicine, Brazilian Cochrane Centre, Federal University of São Paulo, São Paulo, SP, Brazil., Valéria de Andrade Santana M; Department of Evidence-Based Medicine, Brazilian Cochrane Centre, Federal University of São Paulo, São Paulo, SP, Brazil., Pereira Nunes Pinto AC; Department of Evidence-Based Medicine, Brazilian Cochrane Centre, Federal University of São Paulo, São Paulo, SP, Brazil.; Department of Physical Therapy, University of Pittsburgh, Fullbright Program, USA., Tutiya KK; Department of Geriatrics and Gerontology, Federal University of São Paulo, São Paulo, SP, Brazil., Gazoni FM; Department of Geriatrics and Gerontology, Federal University of São Paulo, São Paulo, SP, Brazil.; Department of Evidence-Based Medicine, Brazilian Cochrane Centre, Federal University of São Paulo, São Paulo, SP, Brazil., Pinto CB; Laboratory of Neuromodulation, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Cristina Dos Santos F; Department of Geriatrics and Gerontology, Federal University of São Paulo, São Paulo, SP, Brazil., Fregni F; Laboratory of Neuromodulation, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
المصدر: Heliyon [Heliyon] 2020 Dec 19; Vol. 6 (12), pp. e05723. Date of Electronic Publication: 2020 Dec 19 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: Data on the precise mechanisms of the complex interactions of factors related to clinical impact of knee osteoarthritis (KOA) in the elderly population remain limited. To find predictors that explain pain intensity, physical function, and quality of life in elderly KOA subjects, we performed a cross-sectional analysis of the baseline data from a randomized trial. The trial included 104 subjects (aged ≥60) with KOA pain and dysfunctional endogenous pain-inhibitory system activity assessed by conditioned pain modulation (CPM). Three multiple linear regression models were performed to understand the independent predictors of Brief Pain Inventory (BPI), WOMAC function subscale (WOMACFunc), and SF-12 physical subscale (SF12-PCS). Model 1 showed that BPI pain score was predicted by low CPM response, high von-Frey light touch threshold, worse radiological severity as indexed by Kellgren-Lawrence grade (KL), high von-Frey punctate pain intensity and high levels of anxiety (adjusted R2 = 27.1%, F (6,95) = 7.27, P < 0.0001). In model 2, von-Frey light touch threshold, KL, depressive symptoms indexed by Beck Depression Inventory (BDI), level of sleepiness and pain pressure threshold were risk factors for SF12-PCS (adjusted R2 = 31.9%, F (5,96) = 10.5, P < 0.0001). Finally, model 3 showed that WOMACFunc was predicted by BDI, KL and BPI (adjusted R2 = 41%, F (3,98) = 24.42, P < 0.0001). Our data provides an interesting framework to understand the predictors of KOA pain in the elderly and highlights how its related outcomes are affected by disease-specific factors, somatosensory dysfunction and emotional factors.
Competing Interests: The authors declare no conflict of interest.
(© 2020 The Authors.)
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فهرسة مساهمة: Keywords: Aging; Aging and life course; Central sensitization; Chronic pain; Conditioned pain modulation; Diagnostics; Elderly; Knee osteoarthritis; Multiple regression analysis; Musculoskeletal system; Nervous system; Neuroscience; Rehabilitation; Systems neuroscience
تواريخ الأحداث: Date Created: 20201230 Latest Revision: 20201231
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7758370
DOI: 10.1016/j.heliyon.2020.e05723
PMID: 33376818
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2020.e05723