دورية أكاديمية
أعرض في EDS

Exercise-food challenge test in patients with wheat-dependent exercise-induced anaphylaxis.

التفاصيل البيبلوغرافية
العنوان: Exercise-food challenge test in patients with wheat-dependent exercise-induced anaphylaxis.
المؤلفون: Srisuwatchari W; Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand., Sompornrattanaphan M; Division of Allergy and Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand., Jirapongsananuruk O; Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand., Visitsunthorn N; Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand., Pacharn P; Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.
المصدر: Asian Pacific journal of allergy and immunology [Asian Pac J Allergy Immunol] 2024 Mar; Vol. 42 (1), pp. 43-49.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Allergy and Immunology Society of Thailand Country of Publication: Thailand NLM ID: 8402034 Publication Model: Print Cited Medium: Internet ISSN: 0125-877X (Print) Linking ISSN: 0125877X NLM ISO Abbreviation: Asian Pac J Allergy Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Bangkok : Allergy and Immunology Society of Thailand
Original Publication: [Bangkok : Bangkok Medical Publishers, c1983-
مواضيع طبية MeSH: Anaphylaxis*/diagnosis , Anaphylaxis*/etiology , Wheat Hypersensitivity*/diagnosis , Urticaria* , Exercise-Induced Allergies*, Adult ; Humans ; Child ; Gliadin ; Retrospective Studies ; Immunoglobulin E ; Allergens
مستخلص: Background: Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a severe and potentially life-threatening food allergy. Diagnosis of WDEIA is challenging because reactions are not always reproducible.
Objective: This study aimed to evaluate the positivity rate of exercise-food challenge test at our allergy unit in order to confirm the diagnosis, and to investigate the effect on the episode of reactions after the test.
Methods: This retrospective evaluation included patients aged 5-60 years who presented at the pediatric and adult allergy units of Siriraj Hospital during 2014-2018 with a convincing history of WDEIA and who underwent a 4-day exercise-food challenge test. Demographic data, challenge test result, and episodes of the reaction before and after the challenge test were obtained.
Results: Fourteen of the 17 patients that were enrolled were included in the analysis. The 3 excluded patients were found to have IgE-mediated wheat allergy. Median age and time to diagnosis was 18.3 years (range: 10.5-43.4) and 1.8 years (range: 0.3-6.2). History of recurrent acute urticaria before the onset of anaphylaxis was reported in 5 patients (35.7%). Exercise-food challenge test was positive in 10 patients (71.4%). Median mean number of exacerbations per year before and after the confirmation test was 2 (range: 1-10) and 1 (range: 0-3), respectively.
Conclusions: For WDEIA, time to diagnosis was delayed, and one-third of patients had recurrent acute urticaria proceeding anaphylaxis onset. Our exercise-food challenge test could be utilized safely in both children and adult and able to elicit symptoms in two-third of patients.
المشرفين على المادة: 9007-90-3 (Gliadin)
37341-29-0 (Immunoglobulin E)
0 (Allergens)
تواريخ الأحداث: Date Created: 20210102 Date Completed: 20240325 Latest Revision: 20240325
رمز التحديث: 20240325
DOI: 10.12932/AP-250520-0856
PMID: 33386792
قاعدة البيانات: MEDLINE
الوصف
تدمد:0125-877X
DOI:10.12932/AP-250520-0856