دورية أكاديمية
Exercise-food challenge test in patients with wheat-dependent exercise-induced anaphylaxis.
العنوان: | Exercise-food challenge test in patients with wheat-dependent exercise-induced anaphylaxis. |
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المؤلفون: | Srisuwatchari W; Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand., Sompornrattanaphan M; Division of Allergy and Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand., Jirapongsananuruk O; Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand., Visitsunthorn N; Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand., Pacharn P; Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand. |
المصدر: | Asian Pacific journal of allergy and immunology [Asian Pac J Allergy Immunol] 2024 Mar; Vol. 42 (1), pp. 43-49. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Allergy and Immunology Society of Thailand Country of Publication: Thailand NLM ID: 8402034 Publication Model: Print Cited Medium: Internet ISSN: 0125-877X (Print) Linking ISSN: 0125877X NLM ISO Abbreviation: Asian Pac J Allergy Immunol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Bangkok : Allergy and Immunology Society of Thailand Original Publication: [Bangkok : Bangkok Medical Publishers, c1983- |
مواضيع طبية MeSH: | Anaphylaxis*/diagnosis , Anaphylaxis*/etiology , Wheat Hypersensitivity*/diagnosis , Urticaria* , Exercise-Induced Allergies*, Adult ; Humans ; Child ; Gliadin ; Retrospective Studies ; Immunoglobulin E ; Allergens |
مستخلص: | Background: Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a severe and potentially life-threatening food allergy. Diagnosis of WDEIA is challenging because reactions are not always reproducible. Objective: This study aimed to evaluate the positivity rate of exercise-food challenge test at our allergy unit in order to confirm the diagnosis, and to investigate the effect on the episode of reactions after the test. Methods: This retrospective evaluation included patients aged 5-60 years who presented at the pediatric and adult allergy units of Siriraj Hospital during 2014-2018 with a convincing history of WDEIA and who underwent a 4-day exercise-food challenge test. Demographic data, challenge test result, and episodes of the reaction before and after the challenge test were obtained. Results: Fourteen of the 17 patients that were enrolled were included in the analysis. The 3 excluded patients were found to have IgE-mediated wheat allergy. Median age and time to diagnosis was 18.3 years (range: 10.5-43.4) and 1.8 years (range: 0.3-6.2). History of recurrent acute urticaria before the onset of anaphylaxis was reported in 5 patients (35.7%). Exercise-food challenge test was positive in 10 patients (71.4%). Median mean number of exacerbations per year before and after the confirmation test was 2 (range: 1-10) and 1 (range: 0-3), respectively. Conclusions: For WDEIA, time to diagnosis was delayed, and one-third of patients had recurrent acute urticaria proceeding anaphylaxis onset. Our exercise-food challenge test could be utilized safely in both children and adult and able to elicit symptoms in two-third of patients. |
المشرفين على المادة: | 9007-90-3 (Gliadin) 37341-29-0 (Immunoglobulin E) 0 (Allergens) |
تواريخ الأحداث: | Date Created: 20210102 Date Completed: 20240325 Latest Revision: 20240325 |
رمز التحديث: | 20240325 |
DOI: | 10.12932/AP-250520-0856 |
PMID: | 33386792 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0125-877X |
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DOI: | 10.12932/AP-250520-0856 |