دورية أكاديمية
Analysis of total microcystins and nodularins by oxidative cleavage of their ADMAdda, DMAdda, and Adda moieties.
| العنوان: | Analysis of total microcystins and nodularins by oxidative cleavage of their ADMAdda, DMAdda, and Adda moieties. |
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| المؤلفون: | Foss AJ; GreenWater Laboratories/CyanoLab, 205 Zeagler Drive, Palatka, FL, 32177, USA., Miles CO; Measurement Science and Standards, National Research Council, 1411 Oxford Street, Halifax, NS, B3H 3Z1, Canada.; Norwegian Veterinary Institute, P. O. Box 750, Sentrum, N-0106, Oslo, Norway., Wilkins AL; Norwegian Veterinary Institute, P. O. Box 750, Sentrum, N-0106, Oslo, Norway.; Chemistry Department, University of Waikato, Private Bag 3105, 3240, Hamilton, New Zealand.; Department of Chemistry, University of Oslo, P.O. Box 1033, N-0315, Oslo, Norway., Rise F; Department of Chemistry, University of Oslo, P.O. Box 1033, N-0315, Oslo, Norway., Trovik KW; Department of Chemistry, University of Oslo, P.O. Box 1033, N-0315, Oslo, Norway., Cieslik K; GreenWater Laboratories/CyanoLab, 205 Zeagler Drive, Palatka, FL, 32177, USA., Aubel MT; GreenWater Laboratories/CyanoLab, 205 Zeagler Drive, Palatka, FL, 32177, USA. |
| المصدر: | Analytica chimica acta: X [Anal Chim Acta X] 2020 Sep 02; Vol. 6, pp. 100060. Date of Electronic Publication: 2020 Sep 02 (Print Publication: 2020). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101772417 Publication Model: eCollection Cited Medium: Internet ISSN: 2590-1346 (Electronic) Linking ISSN: 25901346 NLM ISO Abbreviation: Anal Chim Acta X Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier B.V., [2019]-[2021] |
| مستخلص: | Microcystins (MCs) and nodularins (NODs) exhibit high structural variability, including modifications of the Adda (3 S -amino-9 S -methoxy-2 S ,6,8 S -trimethyl-10-phenyldeca-4 E ,6 E -dienoic acid) moiety. Variations include 9- O -desmethylAdda (DMAdda) and 9- O -acetylDMAdda (ADMAdda) which, unless targeted, may go undetected. Therefore, reference standards were prepared of [ADMAdda 5 ]MCs and [DMAdda 5 ]MCs, which were analyzed using multiple approaches. The cross-reactivities of the [DMAdda 5 ]- and [ADMAdda 5 ]MC standards were similar to that of MC-LR when analyzed with a protein phosphatase 2A (PP2A) inhibition assay, but were <0.25% when analyzed with an Adda enzyme-linked immunosorbent assay (ELISA). Oxidative cleavage experiments identified compounds that could be used in the analysis of total MCs/NODs in a similar fashion to the 2 R -methyl-3 S -methoxy-4-phenylbutanoic acid (MMPB) technique. Products from oxidative cleavage of both the 4,5- and 6,7-ene of Adda, DMAdda and ADMAdda were observed, and three oxidation products, one from each Adda variant, were chosen for analysis and applied to three field samples and a Nostoc culture. Results from the oxidative cleavage method for total Adda, DMAdda, and ADMAdda were similar to those from the Adda-ELISA, PP2A inhibition, and LC-MS/MS analyses, except for the Nostoc culture where the Adda-ELISA greatly underestimated microcystin levels. This oxidative cleavage method can be used for routine analysis of field samples and to assess the presence of the rarely reported, but toxic, DMAdda/ADMAdda-containing MCs and NODs. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Crown Copyright © 2020 Published by Elsevier B.V.) |
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| فهرسة مساهمة: | Keywords: ADMAdda; ADMAdda, 3S-amino-9S-acetyloxy-2S,6,8S-trimethyl-10-phenyldeca-4E,6E-dienoic acid; Adda; Adda, 3S-amino-9S-methoxy-2S,6,8S-trimethyl-10-phenyldeca-4E,6E-dienoic acid; DMAdda; DMAdda, 3S-amino-9S-hydroxy-2S,6,8S-trimethyl-10-phenyldeca-4E,6E-dienoic acid; MAPB, 2R-methyl-3S-acetyloxy-4-phenylbutanoic acid; MHPB, 2R-methyl-3S-hydroxy-4-phenylbutanoic acid; MMPB; MMPB, 2R-methyl-3S-methoxy-4-phenylbutanoic acid; MOMAPH, 2-methyl-3-oxo-4R-methyl-5S-acetyloxy-6-phenylhexanoic acid; MOMHPH, 2-methyl-3-oxo-4R-methyl-5S-hydroxy-6-phenylhexanoic acid; MOMMPH, 2-methyl-3-oxo-4R-methyl-5S-methoxy-6-phenylhexanoic acid; Microcystin; Microcystin, MC; NOD, Nodularin; Nodularin |
| تواريخ الأحداث: | Date Created: 20210104 Latest Revision: 20240330 |
| رمز التحديث: | 20240330 |
| مُعرف محوري في PubMed: | PMC7772689 |
| DOI: | 10.1016/j.acax.2020.100060 |
| PMID: | 33392496 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2590-1346 |
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| DOI: | 10.1016/j.acax.2020.100060 |