دورية أكاديمية
Emerging peptide antibiotics with therapeutic potential.
العنوان: | Emerging peptide antibiotics with therapeutic potential. |
---|---|
المؤلفون: | Upert G; Polyphor Ltd, Hegenheimermattweg 125, 4123 Allschwil, Switzerland., Luther A; Bachem AG, Hauptstrasse 114, 4416 Bubendorf, Switzerland., Obrecht D; Polyphor Ltd, Hegenheimermattweg 125, 4123 Allschwil, Switzerland., Ermert P; Polyphor Ltd, Hegenheimermattweg 125, 4123 Allschwil, Switzerland. |
المصدر: | Medicine in drug discovery [Med Drug Discov] 2021 Mar; Vol. 9, pp. 100078. Date of Electronic Publication: 2020 Dec 30. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101765689 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2590-0986 (Electronic) Linking ISSN: 25900986 NLM ISO Abbreviation: Med Drug Discov Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier B.V., [2019]- |
مستخلص: | This review covers some of the recent progress in the field of peptide antibiotics with a focus on compounds with novel or established mode of action and with demonstrated efficacy in animal infection models. Novel drug discovery approaches, linear and macrocyclic peptide antibiotics, lipopeptides like the polymyxins as well as peptides addressing targets located in the plasma membrane or in the outer membrane of bacterial cells are discussed. Competing Interests: Gregory Upert, Daniel Obrecht and Philipp Ermert are employees of Polyphor Ltd. Anatol Luther is an employee of Bachem AG. (© 2021 The Authors.) |
References: | J Antibiot (Tokyo). 2017 Apr;70(4):386-394. (PMID: 28074057) Chem Commun (Camb). 2017 Oct 12;53(82):11357-11359. (PMID: 28967925) J Med Chem. 2014 Feb 13;57(3):1127-31. (PMID: 24479847) Sci Rep. 2017 Jun 13;7(1):3392. (PMID: 28611436) Curr Med Chem. 2009;16(30):3996-4002. (PMID: 19747127) J Biol Chem. 2004 Aug 27;279(35):36250-8. (PMID: 15173160) Sci Adv. 2018 Nov 14;4(11):eaau2634. (PMID: 30443594) J Med Chem. 2010 Jul 22;53(14):5240-7. (PMID: 20565063) Science. 2010 Feb 19;327(5968):1010-3. (PMID: 20167788) Front Chem. 2017 Mar 20;5:15. (PMID: 28373972) J Med Chem. 2015 Dec 24;58(24):9779-85. (PMID: 26636619) Antimicrob Agents Chemother. 2003 Feb;47(2):447-57. (PMID: 12543643) Bioorg Med Chem. 2012 Jan 15;20(2):859-65. (PMID: 22222159) J Org Chem. 2018 Jul 6;83(13):7271-7275. (PMID: 29357665) Nat Microbiol. 2018 Apr;3(4):415-422. (PMID: 29434326) Antimicrob Agents Chemother. 2014;58(4):1922-9. (PMID: 24419352) Antimicrob Agents Chemother. 2019 May 24;63(6):. (PMID: 30936101) Trends Pharmacol Sci. 2019 Jul;40(7):517-528. (PMID: 31230616) Nature. 2018 Sep;561(7722):189-194. (PMID: 30209367) Mol Cell. 2018 Apr 5;70(1):83-94.e7. (PMID: 29625040) Protein Pept Lett. 2014 Apr;21(4):407-12. (PMID: 24164259) Nature. 1998 Nov 12;396(6707):186-90. (PMID: 9823901) Cell Mol Life Sci. 2011 Jul;68(13):2317-30. (PMID: 21594684) Cell. 2020 Apr 2;181(1):29-45. (PMID: 32197064) J Med Chem. 2010 Mar 11;53(5):1898-916. (PMID: 19874036) J Med Chem. 2011 Jul 28;54(14):4954-63. (PMID: 21630667) Peptides. 2012 Jul;36(1):109-13. (PMID: 22537943) J Am Chem Soc. 2004 Feb 4;126(4):1041-3. (PMID: 14746470) Biotechnol Lett. 2018 Oct;40(9-10):1271-1287. (PMID: 29968134) Nat Struct Mol Biol. 2015 Jun;22(6):470-5. (PMID: 25984971) Chem Rev. 2005 Feb;105(2):449-76. (PMID: 15700952) Antimicrob Agents Chemother. 2016 Dec 27;61(1):. (PMID: 27795369) Med Res Rev. 2016 Jan;36(1):4-31. (PMID: 24866700) Front Microbiol. 2019 Oct 02;10:2283. (PMID: 31632382) Future Microbiol. 2019 Apr;14:457-460. (PMID: 31033354) Antimicrob Agents Chemother. 2015 May;59(5):2525-30. (PMID: 25691641) Drug Discov Today Technol. 2012 Spring;9(1):e1-e70. (PMID: 24064246) Infect Immun. 1989 Oct;57(10):3142-6. (PMID: 2777377) J Antimicrob Chemother. 2016 Apr;71(4):1003-11. (PMID: 26832757) Nature. 2019 Mar;567(7749):550-553. (PMID: 30894747) Lancet. 2020 Mar 28;395(10229):1054-1062. (PMID: 32171076) Antimicrob Agents Chemother. 2016 Jul 22;60(8):4991-5000. (PMID: 27297477) Org Biomol Chem. 2017 Oct 25;15(41):8755-8760. (PMID: 28993827) Future Med Chem. 2020 Jul;12(13):1253-1279. (PMID: 32538147) Front Microbiol. 2017 Mar 06;8:343. (PMID: 28321210) Nat Rev Drug Discov. 2013 May;12(5):371-87. (PMID: 23629505) J Am Chem Soc. 2018 Oct 31;140(43):14028-14032. (PMID: 30296063) Biochim Biophys Acta. 2006 Nov;1760(11):1732-40. (PMID: 17059867) Antimicrob Agents Chemother. 2016 Oct 21;60(11):6510-6517. (PMID: 27550357) ACS Chem Biol. 2016 Jul 15;11(7):1823-6. (PMID: 27232661) J Antibiot (Tokyo). 2020 Jun;73(6):329-364. (PMID: 32152527) J Am Chem Soc. 2001 Sep 5;123(35):8640-1. (PMID: 11525690) J Am Chem Soc. 2003 Jul 23;125(29):8736-7. (PMID: 12862463) Nature. 2019 Dec;576(7787):452-458. (PMID: 31645764) J Am Chem Soc. 2007 Jul 18;129(28):8747-55. (PMID: 17592838) Org Lett. 2016 Jun 3;18(11):2788-91. (PMID: 27191730) J Microbiol Biotechnol. 2019 Jan 28;29(1):1-10. (PMID: 29996592) Ann N Y Acad Sci. 2020 Jan;1459(1):86-105. (PMID: 31792983) Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-5. (PMID: 8577744) J Antimicrob Chemother. 2013 Jun;68(6):1213-9. (PMID: 23412346) J Mol Biol. 2013 Jul 24;425(14):2463-79. (PMID: 23562829) Antibiotics (Basel). 2019 Jul 24;8(3):. (PMID: 31344885) Nat Microbiol. 2018 Apr;3(4):392-393. (PMID: 29588534) J Am Chem Soc. 2004 Jun 23;126(24):7462-3. (PMID: 15198592) Expert Rev Anti Infect Ther. 2018 Apr;16(4):259-268. (PMID: 29451043) J Med Chem. 2018 Sep 13;61(17):7814-7826. (PMID: 30086230) Antimicrob Agents Chemother. 1998 Sep;42(9):2215-20. (PMID: 9736537) Front Microbiol. 2018 Jul 11;9:1535. (PMID: 30050518) Antimicrob Agents Chemother. 2012 Oct;56(10):5054-60. (PMID: 22802255) Nat Prod Rep. 2017 Jul 1;34(7):832-885. (PMID: 28530279) Biochim Biophys Acta Biomembr. 2020 Nov 1;1862(11):183432. (PMID: 32781154) Bioorg Med Chem. 2018 Jun 1;26(10):2850-2858. (PMID: 28886999) J Am Chem Soc. 2011 Nov 16;133(45):18010-3. (PMID: 21999343) Chembiochem. 2014 Jan 24;15(2):243-9. (PMID: 24382692) Chem Sci. 2017 Dec 1;8(12):8183-8192. (PMID: 29568465) J Antimicrob Chemother. 2012 Oct;67(10):2445-51. (PMID: 22729924) Biopolymers. 2015 Nov;104(6):707-11. (PMID: 25968331) ACS Chem Biol. 2012 Jul 20;7(7):1281-91. (PMID: 22594381) IUCrJ. 2016 Jan 01;3(Pt 1):10-9. (PMID: 26870377) Bioorg Med Chem. 2016 Dec 15;24(24):6227-6252. (PMID: 27658795) J Med Chem. 2018 Mar 8;61(5):2009-2017. (PMID: 29363971) Angew Chem Int Ed Engl. 2015 Jun 1;54(23):6684-6. (PMID: 25968231) Front Microbiol. 2020 May 13;11:909. (PMID: 32477309) J Nat Prod. 2020 Jul 24;83(7):2112-2121. (PMID: 32614583) ACS Chem Biol. 2018 Mar 16;13(3):666-675. (PMID: 29359918) ACS Omega. 2016 Dec 31;1(6):1262-1265. (PMID: 30023506) Front Chem. 2019 Apr 16;7:238. (PMID: 31058133) Bioorg Med Chem Lett. 2009 Nov 1;19(21):6189-91. (PMID: 19783144) Front Microbiol. 2018 Dec 19;9:3177. (PMID: 30619229) Biochem J. 1994 Jun 1;300 ( Pt 2):567-75. (PMID: 8002963) Curr Med Chem. 2009;16(1):42-65. (PMID: 19149562) Nat Commun. 2019 Jul 22;10(1):3268. (PMID: 31332172) Cell Chem Biol. 2018 Apr 19;25(4):380-391.e5. (PMID: 29396290) Nat Chem Biol. 2013 Apr;9(4):222-31. (PMID: 23508188) Cold Spring Harb Perspect Med. 2016 Oct 3;6(10):. (PMID: 27503996) Angew Chem Int Ed Engl. 2014 Nov 3;53(45):12236-9. (PMID: 25220491) J Am Chem Soc. 2018 Feb 14;140(6):2072-2075. (PMID: 29381350) Angew Chem Int Ed Engl. 2020 Nov 2;59(45):19868-19872. (PMID: 32725837) Appl Microbiol Biotechnol. 2014 Sep;98(17):7387-98. (PMID: 24816779) Expert Rev Anti Infect Ther. 2019 Jan;17(1):1-3. (PMID: 30449226) Bioorg Med Chem Lett. 2017 Jun 1;27(11):2407-2409. (PMID: 28454673) Front Med (Lausanne). 2018 Apr 16;5:96. (PMID: 29713630) Antibiotics (Basel). 2019 Mar 16;8(1):. (PMID: 30884839) Chem Biol. 2010 Nov 24;17(11):1223-31. (PMID: 21095572) J Med Chem. 2018 Apr 26;61(8):3409-3421. (PMID: 29629769) Antimicrob Agents Chemother. 2014 Jul;58(7):4200-2. (PMID: 24733472) Chem Biol. 2000 Dec;7(12):931-42. (PMID: 11137816) Biochem Biophys Res Commun. 1994 Feb 28;199(1):339-45. (PMID: 8123032) ACS Infect Dis. 2019 Oct 11;5(10):1645-1656. (PMID: 31525992) Bioorg Med Chem Lett. 2013 Oct 15;23(20):5654-9. (PMID: 24012184) J Am Chem Soc. 2007 Dec 26;129(51):15830-8. (PMID: 18052061) Nat Prod Rep. 2017 Jul 1;34(7):702-711. (PMID: 28537612) Med J Aust. 1970 Nov 14;2(20):923-4. (PMID: 5486295) Int J Antimicrob Agents. 2005 Dec;26(6):504-7. (PMID: 16280245) Clin Infect Dis. 2009 Jan 1;48(1):1-12. (PMID: 19035777) Nat Commun. 2019 Aug 6;10(1):3517. (PMID: 31388008) Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13759-64. (PMID: 19666597) J Antimicrob Chemother. 2020 Jun 1;75(6):1518-1524. (PMID: 32087024) Chembiochem. 2020 Mar 16;21(6):789-792. (PMID: 31552694) Nature. 2015 Jan 22;517(7535):442-4. (PMID: 25561172) FEBS Lett. 2004 Nov 5;577(1-2):209-14. (PMID: 15527787) Lancet Infect Dis. 2018 Mar;18(3):318-327. (PMID: 29276051) Int J Antimicrob Agents. 2008 Nov;32(5):450-4. (PMID: 18768302) Biochemistry. 1996 Sep 24;35(38):12570-5. (PMID: 8823194) Biochemistry. 2020 Feb 4;59(4):343-345. (PMID: 31909599) Nature. 2019 Dec;576(7787):389-390. (PMID: 31844257) Nature. 2020 Jul;583(7816):473-478. (PMID: 32528179) J Biol Chem. 2004 Jul 16;279(29):30781-90. (PMID: 15136583) Chemistry. 2018 Jun 26;24(36):9136-9147. (PMID: 29741277) Nat Rev Drug Discov. 2015 Aug;14(8):529-42. (PMID: 26139286) Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11561-11566. (PMID: 27688760) Nat Biotechnol. 2006 Dec;24(12):1551-7. (PMID: 17160061) J Am Chem Soc. 2003 Feb 19;125(7):1877-87. (PMID: 12580615) J Biochem Mol Biol. 2002 May 31;35(3):291-6. (PMID: 12297012) J Biosci Bioeng. 2016 May;121(5):591-8. (PMID: 26472128) J Antibiot (Tokyo). 2002 Jun;55(6):571-7. (PMID: 12195963) J Med Chem. 2007 Jun 28;50(13):3077-85. (PMID: 17542573) Lancet Infect Dis. 2018 Mar;18(3):256-257. (PMID: 29396009) J Med Chem. 2017 Sep 14;60(17):7476-7482. (PMID: 28795806) J Antibiot (Tokyo). 1978 Jul;31(7):646-51. (PMID: 690000) J Am Chem Soc. 2011 Nov 9;133(44):17869-77. (PMID: 21999324) Nat Struct Mol Biol. 2015 Jun;22(6):466-9. (PMID: 25984972) Bioorg Med Chem. 2017 Sep 15;25(18):4990-4995. (PMID: 28495382) Bioorg Med Chem Lett. 2015 Nov 1;25(21):4761-4766. (PMID: 26276537) Eur J Biochem. 1998 Sep 1;256(2):404-10. (PMID: 9760181) Future Med Chem. 2016 Jun;8(10):1017-25. (PMID: 27328129) Pharmaceutics. 2018 Oct 11;10(4):. (PMID: 30314324) Lett Appl Microbiol. 2014 Jul;59(1):71-8. (PMID: 24617894) Nucleic Acids Res. 2016 Mar 18;44(5):2439-50. (PMID: 26809677) Nat Rev Microbiol. 2020 May;18(5):275-285. (PMID: 31745331) Nature. 2015 Jan 22;517(7535):455-9. (PMID: 25561178) Antimicrob Agents Chemother. 2012 Sep;56(9):4662-70. (PMID: 22710113) Antimicrob Agents Chemother. 2014 Nov;58(11):6819-27. (PMID: 25182650) Chembiochem. 2012 Aug 13;13(12):1767-75. (PMID: 22807320) Chem Commun (Camb). 2017 Feb 28;53(18):2772-2775. (PMID: 28217800) Nat Rev Drug Discov. 2006 Apr;5(4):321-32. (PMID: 16531990) Ann Intern Med. 1970 Jun;72(6):857-68. (PMID: 5448745) Antimicrob Agents Chemother. 2017 Mar 24;61(4):. (PMID: 28167546) Protein Cell. 2018 Oct;9(10):890-895. (PMID: 29256010) Nature. 2019 Dec;576(7787):459-464. (PMID: 31747680) Biochemistry. 2001 Mar 13;40(10):3016-26. (PMID: 11258915) Chem Commun (Camb). 2018 Sep 25;54(75):10634-10637. (PMID: 30179243) Lancet Infect Dis. 2016 Feb;16(2):161-8. (PMID: 26603172) Biochem Pharmacol. 2017 Jun 15;134:87-98. (PMID: 27823963) Chem Commun (Camb). 2016 Apr 26;52(36):6060-3. (PMID: 26984316) Curr Opin Chem Biol. 2017 Jun;38:45-51. (PMID: 28319811) Int J Antimicrob Agents. 2016 Dec;48(6):583-591. (PMID: 27524102) Antimicrob Agents Chemother. 1990 Mar;34(3):413-9. (PMID: 2334153) Curr Opin Gastroenterol. 2017 Jan;33(1):1-7. (PMID: 28134686) Peptides. 2010 Sep;31(9):1669-73. (PMID: 20600431) Nat Commun. 2020 Jun 23;11(1):3184. (PMID: 32576824) |
فهرسة مساهمة: | Keywords: ADMET, absorption, distribution, metabolism and excretion – toxicity in pharmacokinetics; AMP, antimicrobial peptide; AMR, antimicrobial resistance; ATCC, ATCC cell collection; Antibiotic; BAM, β-barrel assembly machinery; CC50, cytotoxic concentration to kill 50% of cells; CD, circular dichroism; CFU, colony forming unit; CLSI, clinical and laboratory standards institute; CMS, colistin methane sulfonate; DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine; ESKAPE, acronym encompassing six bacterial pathogens (often carrying antibiotic resistance): Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp; FDA, U. S. Food and Drug Administration; HABP, hospital acquired bacterial pneumonia; HDP, host-defense peptide; HEK293, human embryonic kidney 293 cells; HK-2, human kidney 2 cells (proximal tubular cell line); HepG2, human hepatocellular carcinoma cell line; Hpg, 4-hydroxy-phenyl glycine; ITC, isothermal titration calorimetry; KPC, Klebsiella pneumoniae metallo-β-lactamase C resistant; LPS, lipopolysaccharide; LptA, lipopolysaccharide transport protein A; LptC, lipopolysaccharide transport protein C; LptD, lipopolysaccharide transport protein D; MDR, multidrug-resistant; MH-I, Müller-Hinton broth I; MH-II, Müller-Hinton broth II (cation adjusted); MIC, minimal inhibitory concentration; MRSA, methicilline-resistant S. aureus; MSSA, methicilline-sensitive S. aureus; MoA, mechanism (mode) of action; NDM-1, New Delhi metallo-β-lactamase resistant; NOAEL, no adverse effect level; ODL, odilorhabdin; OMPTA (outer membrane targeting antibiotic); OMPTA, outer membrane targeting antibiotic; Omp, outer membrane protein; PBMC, peripheral mononuclear blood cell; PBP, penicillin-binding protein; PBS, phosphate-buffered saline; PK, pharmacokinetics; POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPG, 2-oleoyl-1-palmitoyl-sn-glycero-3-phospho-(1-glycerol); PrAMPs, polyproline antimicrobial peptides; RBC, red blood cell; SAR, structure-activity relationship; SPR, surface plasmon resonance; SPase I, signal peptidase I; VABP, ventilator associated bacterial pneumonia; VIM-1, beta-lactamase 2 (K. pneumoniae); VISA, vancomycin-intermediate S. aureus; VRE, vancomycin-resistant enterococcus; WHO, World Health Organization; WT, wild type; WTA, wall teichoic acid; XDR, extremely drug-resistant; antimicrobial peptide; antimicrobial resistance; bid, bis in die (two times a day); i.p., intraperitoneal; i.v., intravenous; lipopeptide; mITT population, minimal intend-to-treat population; peptide antibiotic; s.c., subcutaneous |
تواريخ الأحداث: | Date Created: 20210105 Latest Revision: 20231110 |
رمز التحديث: | 20231110 |
مُعرف محوري في PubMed: | PMC7773004 |
DOI: | 10.1016/j.medidd.2020.100078 |
PMID: | 33398258 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2590-0986 |
---|---|
DOI: | 10.1016/j.medidd.2020.100078 |