دورية أكاديمية
أعرض في EDS

Spectrum of Clinicopathologic Findings in COVID-19-induced Skin Lesions: Demonstration of Direct Viral Infection of the Endothelial Cells.

التفاصيل البيبلوغرافية
العنوان: Spectrum of Clinicopathologic Findings in COVID-19-induced Skin Lesions: Demonstration of Direct Viral Infection of the Endothelial Cells.
المؤلفون: Garrido Ruiz MC; Departments of Pathology., Santos-Briz Á; Departments of Pathology.; Institute for Biomedical Research (IBSAL), Salamanca, Spain., Santos-Briz Á; Departments of Pathology.; Institute for Biomedical Research (IBSAL), Salamanca, Spain., Sánchez A; Dermatology, 12 de Octubre University Hospital, Complutense University of Madrid, Investigation Instutute I+12, CIBERONC, Madrid., Alonso-Riaño M; Departments of Pathology., Burgos J; Departments of Pathology., Medina-Miguelañez M; Dermatology, University Hospital of Salamanca., Puebla L; Dermatology, University Hospital of Salamanca., Román-Curto C; Dermatology, University Hospital of Salamanca., Roncero-Riesco M; Dermatology, University Hospital of Salamanca., Garcia R; Departments of Pathology., Ortiz PL; Dermatology, 12 de Octubre University Hospital, Complutense University of Madrid, Investigation Instutute I+12, CIBERONC, Madrid., Rodriguez-Peralto JL; Departments of Pathology.
المصدر: The American journal of surgical pathology [Am J Surg Pathol] 2021 Mar 01; Vol. 45 (3), pp. 293-303.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 7707904 Publication Model: Print Cited Medium: Internet ISSN: 1532-0979 (Electronic) Linking ISSN: 01475185 NLM ISO Abbreviation: Am J Surg Pathol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2015- > : Philadelphia, PA : Wolters Kluwer Health, Inc.
Original Publication: New York, Masson.
مواضيع طبية MeSH: COVID-19/*diagnosis , Endothelial Cells/*virology , Skin Diseases/*virology, Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/pathology ; COVID-19 Testing ; Endothelial Cells/pathology ; Female ; Humans ; Male ; Microscopy, Electron ; Middle Aged ; Retrospective Studies ; Severity of Illness Index ; Skin Diseases/diagnosis ; Skin Diseases/pathology ; Young Adult
مستخلص: The novel coronavirus disease (COVID-19) is a rapidly spreading pandemic, secondary to severe acute respiratory syndrome coronavirus 2. The severity and the little knowledge that we have of the disease have made us focus mostly on the respiratory symptoms. As we bend the curve, other findings reported in association with COVID-19 become of importance for specialists to recognize. We describe the spectrum of clinicopathologic lesions in the skin that can be the only symptom or the first manifestation of COVID-19 and demonstrate the origin of the virus. We collected 25 patients with skin lesions in this context. We recognized 5 types of cutaneous manifestations including acute acroischemic or chilblain-like lesions (11), purpura palpable (2), exanthemas (9), urticarial eruptions (1), and other lesions (2) that might appear with more unspecific pictures. Chilblain-like lesions were the most common form of presentation, which tend to appear as self-healing, erythematous-necrotic plaques mostly on the feet, in young patients with no systemic symptoms associated. Importantly, we visualized viral particles with electron microscopy in 5 of 13 cases analyzed. In this study, we seek to draw a picture of the spectrum of clinicopathologic lesions that may appear in the skin in the context of COVID-19. Although apparently skin lesions are not correlated with disease severity, it may help in some cases to recognize and control the spread of the infection sooner.
Competing Interests: Conflicts of Interest and Source of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.
(Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
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تواريخ الأحداث: Date Created: 20210105 Date Completed: 20210217 Latest Revision: 20210217
رمز التحديث: 20231215
DOI: 10.1097/PAS.0000000000001634
PMID: 33399338
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-0979
DOI:10.1097/PAS.0000000000001634