دورية أكاديمية
أعرض في EDS

Radioactive Iodine Following Total Thyroidectomy Is Comparable to Lobectomy in Low/Intermediate-Risk Differentiated Thyroid Carcinoma: A Meta-Analysis.

التفاصيل البيبلوغرافية
العنوان: Radioactive Iodine Following Total Thyroidectomy Is Comparable to Lobectomy in Low/Intermediate-Risk Differentiated Thyroid Carcinoma: A Meta-Analysis.
المؤلفون: Altedlawi Albalawi IA 2nd; Surgical Oncology, University of Tabuk, Tabuk, SAU., Altidlawi AI; Surgery, University of Tabuk, Tabuk, SAU., Mirghani H; Internal Medicine, University of Tabuk, Tabuk, SAU.
المصدر: Cureus [Cureus] 2020 Dec 28; Vol. 12 (12), pp. e12332. Date of Electronic Publication: 2020 Dec 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: Electronic Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Radioactive iodine (RAI) is being increasingly used for remnants ablation of low/intermediate-risk differentiated thyroid carcinoma (DTC). Importantly, total thyroidectomy (TT) is in common use in the treatment of low-grade DTC to facilitate RAI despite the recommendations for lobectomy. Intermediate-risk DTC has been an arena of controversy (fueled by weighing the risks and benefits of RAI). This meta-analysis aimed to assess the role of RAI following TT in comparison to lobectomy in low/intermediate-risk patients with DTC. We identified 482 references through PubMed, Cochrane Library, EBSCO, and Google Scholar databases. The keywords used were "differentiated thyroid carcinoma", "low/intermediate risk", "radioactive iodine following total thyroidectomy", "total thyroidectomy versus lobectomy and RAI", "remnants ablation", "recurrence", "survival rate", "tumor-specific cancer death", "overall mortality", and "tumor-specific mortality". From the 67 full texts screened, only seven studies fulfilled the inclusion and exclusion criteria. The studies were from the USA, Australia, Asia, Mexico, and South America (63,268 patients included; five were retrospective and two prospective cohorts). No differences were found regarding recurrence and survival rate between TT followed by RAI and lobectomy alone. However, the current data were limited by the observational studies included, the pooling of both recurrence and survival rate, and the significant heterogeneity observed. The ongoing randomized controlled trials are awaited to resolve the issue.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2020, Altedlawi Albalawi et al.)
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فهرسة مساهمة: Keywords: differentiated thyroid carcinoma; lobectomy; radioactive iodine; remnants ablation; total thyroidectomy
تواريخ الأحداث: Date Created: 20210106 Latest Revision: 20210111
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7773301
DOI: 10.7759/cureus.12332
PMID: 33403191
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.12332