تقرير
IDH1-mutant primary intraventricular gliosarcoma: Case report and systematic review of a rare location and molecular profile.
| العنوان: | IDH1-mutant primary intraventricular gliosarcoma: Case report and systematic review of a rare location and molecular profile. |
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| المؤلفون: | de Macedo Filho LJM; Health Science Center, University of Fortaleza, Ceara, Brazil., Barreto EG; Health Science Center, University of Fortaleza, Ceara, Brazil., Martins PLB; Health Science Center, University of Fortaleza, Ceara, Brazil., Filho ENS; Health Science Center, University of Fortaleza, Ceara, Brazil., Gerson G; Department of Neurosurgery, General Hospital of Fortaleza, Fortaleza, Ceara, Brazil., de Albuquerque LAF; Department of Neurosurgery, General Hospital of Fortaleza, Fortaleza, Ceara, Brazil. |
| المصدر: | Surgical neurology international [Surg Neurol Int] 2020 Nov 06; Vol. 11, pp. 372. Date of Electronic Publication: 2020 Nov 06 (Print Publication: 2020). |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Scientific Scholar LLC Country of Publication: United States NLM ID: 101535836 Publication Model: eCollection Cited Medium: Print ISSN: 2229-5097 (Print) Linking ISSN: 21527806 NLM ISO Abbreviation: Surg Neurol Int Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: Pittsford, NY, USA : Scientific Scholar LLC Original Publication: Mumbai : Medknow |
| مستخلص: | Background: Gliosarcoma (GS) is classified as an IDH-wild-type variant of glioblastoma (GBM). While GS is already an unusual presentation of GBM, IDH1-mutant cases are especially rare. We present an IDH1-mutant primary intraventricular GS case report and a systematic review of the molecular profile in GS correlating to the prognostic and pathogenesis of IDH1/2 mutations. Case Description: A 44-years-old man presented with ongoing fatigue symptoms and a new-onset intense occipital headache. The patient complained of memory loss, dyscalculia, and concentration difficulties. An MRI revealed a bihemispheric intraventricular mass crossing the midline through the corpus callosum and infiltrating the trigone of the lateral ventricles, hypointense, and hyperintense on the T1- and T2-weighted image. We performed a microsurgical resection with a transparietal transsulcal approach; however, the contralateral mass was attached to vascular structures and we decided to reoperate the patient in another moment. The histopathological study showed a Grade IV tumor and the immunohistochemistry confirmed the diagnosis of GS. The patient presented progressive neurologic decline and died 45 days after the surgical approach. Conclusion: We did two systematic reviews studies from PubMed, EMBASE, MEDLINE, Cochrane, and SCOPUS databases, and included molecular and intraventricular studies of GS. We performed further meta-analysis using OpenMetaAnalyst™ software. We conducted a forest plot with the molecular profile of GS. When correlated IDH1 mutation versus tp53 mutation, we found an odds ratio (OR) of 0.018 (0.005-0.064) and P < 0.001. Moreover, we compared IDH1 mutation versus MGMT methylation ( P = 0.006; OR = 0.138 [0.034-0.562]). The studies evaluating the molecular profile in GS prognostics are often extended from all GBMs despite specifics GBM variants (i.e., GS). We found a correlation between IDH1 mutation expression with tp53 and MGMT expression in GS, and future studies exploring this molecular profile in GS are strongly encouraged. Competing Interests: There are no conflicts of interest. (Copyright: © 2020 Surgical Neurology International.) |
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| فهرسة مساهمة: | Keywords: Case report; Cerebral ventricle neoplasms; Gliosarcoma; Human IDH1 protein; Systematic review |
| تواريخ الأحداث: | Date Created: 20210107 Latest Revision: 20220419 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC7771479 |
| DOI: | 10.25259/SNI_586_2020 |
| PMID: | 33408906 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2229-5097 |
|---|---|
| DOI: | 10.25259/SNI_586_2020 |