دورية أكاديمية
ALDH2 protects naturally aged mouse retina via inhibiting oxidative stress-related apoptosis and enhancing unfolded protein response in endoplasmic reticulum.
| العنوان: | ALDH2 protects naturally aged mouse retina via inhibiting oxidative stress-related apoptosis and enhancing unfolded protein response in endoplasmic reticulum. |
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| المؤلفون: | Long P; Department of General Practice, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.; Department of Ophthalmology, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan Province, China.; Center of Clinical Aerospace Medicine, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China., He M; Department of Chinese Material Medical and Natural Medicines, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China., Yan W; Department of Ophthalmology, The 900th Hospital of Joint Logistic Support Force, PLA (Clinical Medical College of Fujian Medical University, Dongfang Hospital Affiliated to Xiamen University), Fuzhou 350025, Fujian Province, China., Chen W; Department of General Practice, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China., Wei D; Center of Clinical Aerospace Medicine, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.; Department of Aviation Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China., Wang S; Department of Chinese Material Medical and Natural Medicines, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China., Zhang Z; Center of Clinical Aerospace Medicine, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.; Department of Aviation Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China., Ge W; Department of General Practice, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China., Chen T; Center of Clinical Aerospace Medicine, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.; Department of Aviation Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China. |
| المصدر: | Aging [Aging (Albany NY)] 2020 Dec 19; Vol. 13 (2), pp. 2750-2767. Date of Electronic Publication: 2020 Dec 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-4589 (Electronic) Linking ISSN: 19454589 NLM ISO Abbreviation: Aging (Albany NY) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Albany, NY : Impact Journals, LLC |
| مواضيع طبية MeSH: | Aging/*metabolism , Aldehyde Dehydrogenase, Mitochondrial/*genetics , Apoptosis/*genetics , Endoplasmic Reticulum/*metabolism , Oxidative Stress/*genetics , Retina/*metabolism , Unfolded Protein Response/*genetics, Aging/pathology ; Aldehyde Dehydrogenase, Mitochondrial/drug effects ; Aldehyde Dehydrogenase, Mitochondrial/metabolism ; Animals ; Apoptosis/drug effects ; Benzamides/pharmacology ; Benzodioxoles/pharmacology ; Electroretinography ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum Chaperone BiP ; Fundus Oculi ; Interleukin-1/metabolism ; Interleukin-6/metabolism ; Mice ; Mice, Transgenic ; Oxidative Stress/drug effects ; Retina/drug effects ; Retina/pathology ; Retina/physiopathology ; Tomography, Optical Coherence ; Tumor Necrosis Factor-alpha/metabolism ; Unfolded Protein Response/drug effects |
| مستخلص: | During the process of aging, the retina exhibits chronic oxidative stress (OS) damage. Our preliminary experiment showed that acetaldehyde dehydrogenase 2 (ALDH2) could alleviate retinal damage caused by OS. This study aimed to explore whether ALDH2 could inhibit mice retinal cell apoptosis and enhance the function of unfolded protein response in endoplasmic reticulum (UPR ER ) through reducing OS in aging process. Retinal function and structure in vivo and in vitro were examined in aged ALDH2+ overexpression mice and ALDH2 agonist Alda1-treated aged mice. Levels of ALDH2, endoplasmic reticulum stress (ERS), apoptosis and inflammatory cytokines were evaluated. Higher expression of ALDH2 was observed at the outer nuclear layer (ONL) and the inner nuclear layer (INL) in aged ALDH2+ overexpression and aged Alda1-treated mice. Moreover, aged ALDH2+ overexpression mice and aged Alda1-treated mice exhibited better retinal function and structure. Increased expression of glucose-regulated protein 78 (GRP78) and ERS-related protein phosphorylated eukaryotic initiation factor 2 (peIF2α) and decreased expression of apoptosis-related protein, including C/EBP homologous protein (CHOP), caspase12 and caspase9, and retinal inflammatory cytokines were detected in the retina of aged ALDH2+ overexpression mice and aged Alda1-treated mice. The expression of ALDH2 in the retina was decreased in aging process. ALDH2 could reduce retinal oxidative stress and apoptosis, strengthen UPR ER during the aging process to improve retinal function and structure. |
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| فهرسة مساهمة: | Keywords: ALDH2; UPRER; aged mice; oxidative stress; retina |
| المشرفين على المادة: | 0 (Benzamides) 0 (Benzodioxoles) 0 (Endoplasmic Reticulum Chaperone BiP) 0 (Hspa5 protein, mouse) 0 (Interleukin-1) 0 (Interleukin-6) 0 (N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide) 0 (Tumor Necrosis Factor-alpha) EC 1.2.1.3 (ALDH2 protein, mouse) EC 1.2.1.3 (Aldehyde Dehydrogenase, Mitochondrial) |
| تواريخ الأحداث: | Date Created: 20210107 Date Completed: 20210517 Latest Revision: 20211204 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7880320 |
| DOI: | 10.18632/aging.202325 |
| PMID: | 33411685 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1945-4589 |
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| DOI: | 10.18632/aging.202325 |