دورية أكاديمية
أعرض في EDS

Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation.

التفاصيل البيبلوغرافية
العنوان: Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation.
المؤلفون: Salamina M; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Montefiore BC; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Liu M; Department of Biochemistry and Molecular Pharmacology, Perlmutter NYU Cancer Center, New York University Grossman School of Medicine, and Howard Hughes Medical Institute, The Alexandria Center of Life Science, East Tower, 450 E, 29th Street, New York, NY 10016, USA., Wood DJ; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Heath R; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Ault JR; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Wang LZ; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Korolchuk S; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Baslé A; Biosciences Institute, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Pastok MW; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Reeks J; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Tatum NJ; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Sobott F; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Arold ST; Division of Biological and Environmental Sciences and Engineering (BESE), Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia; Centre de Biochimie Structurale, CNRS, INSERM, Université de Montpellier, 34090 Montpellier, France., Pagano M; Department of Biochemistry and Molecular Pharmacology, Perlmutter NYU Cancer Center, New York University Grossman School of Medicine, and Howard Hughes Medical Institute, The Alexandria Center of Life Science, East Tower, 450 E, 29th Street, New York, NY 10016, USA., Noble MEM; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Endicott JA; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address: jane.endicott@ncl.ac.uk.
المصدر: Journal of molecular biology [J Mol Biol] 2021 Mar 05; Vol. 433 (5), pp. 166795. Date of Electronic Publication: 2021 Jan 07.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: 1959- : London : Academic Press
مواضيع طبية MeSH: G1 Phase Cell Cycle Checkpoints*, Cyclin A/*chemistry , Cyclin-Dependent Kinase 2/*chemistry , Cyclin-Dependent Kinase Inhibitor p27/*chemistry , S-Phase Kinase-Associated Proteins/*chemistry, Binding Sites ; CDC2-CDC28 Kinases/chemistry ; CDC2-CDC28 Kinases/genetics ; CDC2-CDC28 Kinases/metabolism ; Cyclin A/genetics ; Cyclin A/metabolism ; Cyclin E/chemistry ; Cyclin E/genetics ; Cyclin E/metabolism ; Cyclin-Dependent Kinase 2/genetics ; Cyclin-Dependent Kinase 2/metabolism ; Cyclin-Dependent Kinase Inhibitor p27/genetics ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Gene Expression Regulation ; HEK293 Cells ; Humans ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Proteolysis ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; S-Phase Kinase-Associated Proteins/genetics ; S-Phase Kinase-Associated Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Signal Transduction
مستخلص: The SCF SKP2 ubiquitin ligase relieves G1 checkpoint control of CDK-cyclin complexes by promoting p27KIP1 degradation. We describe reconstitution of stable complexes containing SKP1-SKP2 and CDK1-cyclin B or CDK2-cyclin A/E, mediated by the CDK regulatory subunit CKS1. We further show that a direct interaction between a SKP2 N-terminal motif and cyclin A can stabilize SKP1-SKP2-CDK2-cyclin A complexes in the absence of CKS1. We identify the SKP2 binding site on cyclin A and demonstrate the site is not present in cyclin B or cyclin E. This site is distinct from but overlapping with features that mediate binding of p27KIP1 and other G1 cyclin regulators to cyclin A. We propose that the capacity of SKP2 to engage with CDK2-cyclin A by more than one structural mechanism provides a way to fine tune the degradation of p27KIP1 and distinguishes cyclin A from other G1 cyclins to ensure orderly cell cycle progression.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
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معلومات مُعتمدة: G0901526 United Kingdom MRC_ Medical Research Council; C2115/A21421 United Kingdom CRUK_ Cancer Research UK; G0800014 United Kingdom MRC_ Medical Research Council; 063551 United Kingdom WT_ Wellcome Trust; R37 CA076584 United States CA NCI NIH HHS; R01 CA076584 United States CA NCI NIH HHS; United Kingdom WT_ Wellcome Trust; MR/N009738/1 United Kingdom MRC_ Medical Research Council; R35 GM136250 United States GM NIGMS NIH HHS; United States HHMI Howard Hughes Medical Institute; BB/M012573/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council
فهرسة مساهمة: Keywords: cell cycle; checkpoint; protein kinase; signaling; ubiquitination
المشرفين على المادة: 0 (CDKN1B protein, human)
0 (CKS1B protein, human)
0 (Cyclin A)
0 (Cyclin E)
0 (Recombinant Proteins)
0 (S-Phase Kinase-Associated Proteins)
0 (SKP1 protein, human)
0 (SKP2 protein, human)
147604-94-2 (Cyclin-Dependent Kinase Inhibitor p27)
EC 2.7.11.22 (CDC2-CDC28 Kinases)
EC 2.7.11.22 (CDK2 protein, human)
EC 2.7.11.22 (Cyclin-Dependent Kinase 2)
تواريخ الأحداث: Date Created: 20210110 Date Completed: 20210506 Latest Revision: 20240320
رمز التحديث: 20240320
مُعرف محوري في PubMed: PMC7895821
DOI: 10.1016/j.jmb.2020.166795
PMID: 33422522
قاعدة البيانات: MEDLINE
الوصف
تدمد:1089-8638
DOI:10.1016/j.jmb.2020.166795