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Chronic generalized pain disrupts whole brain functional connectivity in mice.

التفاصيل البيبلوغرافية
العنوان: Chronic generalized pain disrupts whole brain functional connectivity in mice.
المؤلفون: Nasseef MT; Douglas Hospital Research Center, Department of Psychiatry, School of Medicine, McGill University, Montreal, Quebec, Canada., Ma W; Douglas Hospital Research Center, Department of Psychiatry, School of Medicine, McGill University, Montreal, Quebec, Canada., Singh JP; Douglas Hospital Research Center, Department of Psychiatry, School of Medicine, McGill University, Montreal, Quebec, Canada., Dozono N; Department of Molecular Pharmacology, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, 606-8501, Japan., Lançon K; Montreal Neurological institute, Department of Neurology & Neurosurgery, the Alan Edwards Centre for Research on Pain, Montreal Neurological Institute, Dept. Neurology & Neurosurgery, McGill University, Montreal, Quebec, Canada., Séguéla P; Montreal Neurological institute, Department of Neurology & Neurosurgery, the Alan Edwards Centre for Research on Pain, Montreal Neurological Institute, Dept. Neurology & Neurosurgery, McGill University, Montreal, Quebec, Canada., Darcq E; Douglas Hospital Research Center, Department of Psychiatry, School of Medicine, McGill University, Montreal, Quebec, Canada., Ueda H; Department of Molecular Pharmacology, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, 606-8501, Japan., Kieffer BL; Douglas Hospital Research Center, Department of Psychiatry, School of Medicine, McGill University, Montreal, Quebec, Canada. brigitte.kieffer@douglas.mcgill.ca.; Douglas Hospital Research Center, Perry Pavilion Room E-3317.1, 6875 boulevard LaSalle, Montreal, Quebec, H4H 1R3, Canada. brigitte.kieffer@douglas.mcgill.ca.
المصدر: Brain imaging and behavior [Brain Imaging Behav] 2021 Oct; Vol. 15 (5), pp. 2406-2416. Date of Electronic Publication: 2021 Jan 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101300405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-7565 (Electronic) Linking ISSN: 19317557 NLM ISO Abbreviation: Brain Imaging Behav Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Secaucus, NJ : Springer
مواضيع طبية MeSH: Chronic Pain*/diagnostic imaging , Fibromyalgia*, Animals ; Brain/diagnostic imaging ; Brain Mapping ; Magnetic Resonance Imaging ; Mice ; Neural Pathways/diagnostic imaging
مستخلص: Fibromyalgia (FM) is a generalized chronic pain condition whose pathophysiology is poorly understood, and both basic and translational research are needed to advance the field. Here we used the Sluka model to test whether FM-like pain in mice would produce detectable brain modifications using resting-state (rs) functional Magnetic Resonance Imaging (fMRI). Mice received intramuscular acid saline treatment, images were acquired at 7 T 5 days post-treatment, and pain thresholds tested 3 weeks post-scanning. Data-driven Independent Component Analysis revealed significant reduction of functional connectivity (FC) across several component pairs, with major changes for the Retrosplenial cortex (RSP) central to the default mode network, and to a lesser extent the Periaqueductal gray (PAG), a key pain processing area. Seed-to-seed analysis focused on 14 pain-related areas showed strongest FC reduction for RSP with several cortical areas (somatosensory, prefrontal and insular), and for PAG with both cortical (somatosensory) and subcortical (habenula, thalamus, parabrachial nucleus) areas. RSP-PAG FC was also reduced, and this decreased FC tended to be positively correlated with pain levels at individual subject level. Finally, seed-voxelwise analysis focused on PAG confirmed seed-to-seed findings and, also detected reduced PAG FC with the anterior cingulate cortex, increasingly studied in aversive pain effects. In conclusion, FM-like pain triggers FC alterations in the mouse, which are detected by rs-fMRI and are reminiscent of some human findings. The study reveals the causal fingerprint of FM-like pain in rodents, and indicates that both RSP and PAG connectional patterns could be suitable biomarkers, with mechanistic and translational value, for further investigations.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.)
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معلومات مُعتمدة: P50 DA005010 United States DA NIDA NIH HHS; U01 AA016658 United States AA NIAAA NIH HHS; 16658 United States AA NIAAA NIH HHS; 05010 United States DA NIDA NIH HHS; 05010 United States DA NIDA NIH HHS; 16658 United States AA NIAAA NIH HHS
فهرسة مساهمة: Keywords: Biomarker; Fibromyalgia; Mice; Periaqueductal gray; Resting-state fMRI; Retrosplenial cortex; Sluka model
تواريخ الأحداث: Date Created: 20210111 Date Completed: 20211012 Latest Revision: 20211014
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8272737
DOI: 10.1007/s11682-020-00438-9
PMID: 33428113
قاعدة البيانات: MEDLINE
الوصف
تدمد:1931-7565
DOI:10.1007/s11682-020-00438-9