دورية أكاديمية

Synthesis and Properties of Cleavable Quaternary Ammonium Compounds.

التفاصيل البيبلوغرافية
العنوان: Synthesis and Properties of Cleavable Quaternary Ammonium Compounds.
المؤلفون: Gilbert EA; Universidad Nacional del Litoral, CONICET, Grupo de Medio Ambiente, Instituto de Desarrollo Tecnológico para la Industria Química (INTEC)., Guastavino JF; Universidad Nacional del Litoral, CONICET, Grupo de Medio Ambiente, Instituto de Desarrollo Tecnológico para la Industria Química (INTEC)., Nicollier RA; Universidad Nacional del Litoral, CONICET, Grupo de Medio Ambiente, Instituto de Desarrollo Tecnológico para la Industria Química (INTEC)., Lancelle MV; Universidad Nacional del Litoral, CONICET, Cátedra de Microbiología, Departamento de Ingeniería en Alimentos y Biotecnología, Facultad de Ingeniería Química., Russell-White K; Universidad Nacional del Litoral, CONICET, Cátedra de Microbiología, Departamento de Ingeniería en Alimentos y Biotecnología, Facultad de Ingeniería Química., Murguía MC; Universidad Nacional del Litoral, CONICET, Grupo de Medio Ambiente, Instituto de Desarrollo Tecnológico para la Industria Química (INTEC).
المصدر: Journal of oleo science [J Oleo Sci] 2021; Vol. 70 (1), pp. 59-65.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Japan Oil Chemists' Society Country of Publication: Japan NLM ID: 101175339 Publication Model: Print Cited Medium: Internet ISSN: 1347-3352 (Electronic) Linking ISSN: 13458957 NLM ISO Abbreviation: J Oleo Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Tokyo : Japan Oil Chemists' Society
مواضيع طبية MeSH: Anti-Bacterial Agents*, Benzalkonium Compounds/*chemical synthesis , Quaternary Ammonium Compounds/*chemical synthesis , Quaternary Ammonium Compounds/*pharmacology , Surface-Active Agents/*chemical synthesis, Anti-Infective Agents, Local ; Benzalkonium Compounds/chemistry ; Benzalkonium Compounds/pharmacology ; Biodegradation, Environmental ; Carbonates ; Deanol/chemistry ; Disinfectants ; Fatty Alcohols/chemistry ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Indicators and Reagents/chemistry ; Quaternary Ammonium Compounds/chemistry ; Structure-Activity Relationship ; Surface Properties
مستخلص: Quaternary ammonium compounds are widely used as antiseptic and disinfectant. It is been a concern that their widespread use will lead to an increase of environmental problems, therefore the development of biodegradable surfactants is necessary. The present research is aimed at the design of novel amphiphilic molecules with similar properties to those already known but more biodegradable. Based on benzalkonium chloride (BAC), novel carbonate cleavable surfactants (CBAC) were synthesized. The breakable carbonate sites make CBAC compounds more degradable and potentially more biodegradable than their non-cleavable BAC analogues. Natural products such as fatty alcohols (C 8 -C 16 ) and N,N-dimethyl-2-aminoethanol were used as reagents for the synthesis of CBAC8-16. These amphiphilic compounds were characterized in terms of surface properties and antimicrobial activity against Gram-positive and Gram-negative bacteria, yeasts and moulds. The novel surfactants showed similar surface activities in aqueous solutions when compared to BAC. Also, the surface activity/structure relationship revealed that carbonate cleavable surfactants with n-decyl group (CBAC10) showed the same behaviour as non-cleavable BAC. Furthermore, compounds containing n-octyl (CBAC8), n-decyl (CBAC10) and n-dodecyl (CBAC12) group showed strong antimicrobial activities.
فهرسة مساهمة: Keywords: antimicrobial activity; carbonate; cleavable surfactants; quaternary ammonium; surface activity
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Anti-Infective Agents, Local)
0 (Benzalkonium Compounds)
0 (Carbonates)
0 (Disinfectants)
0 (Fatty Alcohols)
0 (Indicators and Reagents)
0 (Quaternary Ammonium Compounds)
0 (Surface-Active Agents)
2N6K9DRA24 (Deanol)
تواريخ الأحداث: Date Created: 20210112 Date Completed: 20210513 Latest Revision: 20210513
رمز التحديث: 20221213
DOI: 10.5650/jos.ess20216
PMID: 33431773
قاعدة البيانات: MEDLINE
الوصف
تدمد:1347-3352
DOI:10.5650/jos.ess20216