دورية أكاديمية
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Genomic adaptation of Pseudomonas strains to acidity and antibiotics in hydrothermal vents at Kolumbo submarine volcano, Greece.

التفاصيل البيبلوغرافية
العنوان: Genomic adaptation of Pseudomonas strains to acidity and antibiotics in hydrothermal vents at Kolumbo submarine volcano, Greece.
المؤلفون: Bravakos P; Institute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research (IMBBC-HCMR), Gournes Pediados, Heraklion Crete, Greece., Mandalakis M; Institute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research (IMBBC-HCMR), Gournes Pediados, Heraklion Crete, Greece., Nomikou P; Department of Geology and Geoenvironment, National and Kapodistrian University of Athens, Athens, Greece., Anastasiou TI; Institute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research (IMBBC-HCMR), Gournes Pediados, Heraklion Crete, Greece., Kristoffersen JB; Institute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research (IMBBC-HCMR), Gournes Pediados, Heraklion Crete, Greece., Stavroulaki M; Institute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research (IMBBC-HCMR), Gournes Pediados, Heraklion Crete, Greece., Kilias S; Department of Geology and Geoenvironment, National and Kapodistrian University of Athens, Athens, Greece., Kotoulas G; Institute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research (IMBBC-HCMR), Gournes Pediados, Heraklion Crete, Greece., Magoulas A; Institute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research (IMBBC-HCMR), Gournes Pediados, Heraklion Crete, Greece., Polymenakou PN; Institute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research (IMBBC-HCMR), Gournes Pediados, Heraklion Crete, Greece. polymen@hcmr.gr.
المصدر: Scientific reports [Sci Rep] 2021 Jan 14; Vol. 11 (1), pp. 1336. Date of Electronic Publication: 2021 Jan 14.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Genome, Bacterial*, Adaptation, Physiological/*genetics , Drug Resistance, Multiple, Bacterial/*genetics , Hydrothermal Vents/*microbiology , Pseudomonas/*genetics , Seawater/*microbiology, Greece ; Pseudomonas/isolation & purification
مستخلص: Although the rise of antibiotic and multidrug resistant bacteria is one of the biggest current threats to human health, our understanding of the mechanisms involved in antibiotic resistance selection remains scarce. We performed whole genome sequencing of 21 Pseudomonas strains, previously isolated from an active submarine volcano of Greece, the Kolumbo volcano. Our goal was to identify the genetic basis of the enhanced co-tolerance to antibiotics and acidity of these Pseudomonas strains. Pangenome analysis identified 10,908 Gene Clusters (GCs). It revealed that the numbers of phage-related GCs and sigma factors, which both provide the mechanisms of adaptation to environmental stressors, were much higher in the high tolerant Pseudomonas strains compared to the rest ones. All identified GCs of these strains were associated with antimicrobial and multidrug resistance. The present study provides strong evidence that the CO 2 -rich seawater of the volcano associated with low pH might be a reservoir of microorganisms carrying multidrug efflux-mediated systems and pumps. We, therefore, suggest further studies of other extreme environments (or ecosystems) and their associated physicochemical parameters (or factors) in the rise of antibiotic resistance.
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تواريخ الأحداث: Date Created: 20210115 Date Completed: 20210810 Latest Revision: 20240330
رمز التحديث: 20240330
مُعرف محوري في PubMed: PMC7809023
DOI: 10.1038/s41598-020-79359-y
PMID: 33446715
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-020-79359-y