دورية أكاديمية
أعرض في EDS

An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations.

التفاصيل البيبلوغرافية
العنوان: An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations.
المؤلفون: de Moraes MH; Department of Microbiology, University of Washington School of Medicine, Seattle, United States., Hsu F; Department of Microbiology, University of Washington School of Medicine, Seattle, United States., Huang D; Department of Physics, University of Washington, Seattle, United States., Bosch DE; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States., Zeng J; Department of Microbiology, University of Washington School of Medicine, Seattle, United States., Radey MC; Department of Microbiology, University of Washington School of Medicine, Seattle, United States., Simon N; Department of Biostatistics, University of Washington School of Public Health, Seattle, United States., Ledvina HE; Department of Microbiology, University of Washington School of Medicine, Seattle, United States., Frick JP; Department of Microbiology, University of Washington School of Medicine, Seattle, United States., Wiggins PA; Department of Physics, University of Washington, Seattle, United States., Peterson SB; Department of Microbiology, University of Washington School of Medicine, Seattle, United States., Mougous JD; Department of Microbiology, University of Washington School of Medicine, Seattle, United States.; Department of Biochemistry, University of Washington School of Medicine, Seattle, United States.; Howard Hughes Medical Institute, University of Washington, Seattle, United States.
المصدر: ELife [Elife] 2021 Jan 15; Vol. 10. Date of Electronic Publication: 2021 Jan 15.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Bacterial Proteins/*metabolism , Bacterial Toxins/*metabolism , Burkholderia cenocepacia/*genetics , Cytosine Deaminase/*metabolism , Escherichia coli/*genetics , Microbial Interactions/*physiology, Mutagenesis
مستخلص: When bacterial cells come in contact, antagonism mediated by the delivery of toxins frequently ensues. The potential for such encounters to have long-term beneficial consequences in recipient cells has not been investigated. Here, we examined the effects of intoxication by DddA, a cytosine deaminase delivered via the type VI secretion system (T6SS) of Burkholderia cenocepacia . Despite its killing potential, we observed that several bacterial species resist DddA and instead accumulate mutations. These mutations can lead to the acquisition of antibiotic resistance, indicating that even in the absence of killing, interbacterial antagonism can have profound consequences on target populations. Investigation of additional toxins from the deaminase superfamily revealed that mutagenic activity is a common feature of these proteins, including a representative we show targets single-stranded DNA and displays a markedly divergent structure. Our findings suggest that a surprising consequence of antagonistic interactions between bacteria could be the promotion of adaptation via the action of directly mutagenic toxins.
Competing Interests: Md, FH, DH, DB, JZ, MR, NS, HL, JF, PW, SP, JM No competing interests declared
(© 2021, de Moraes et al.)
التعليقات: Comment in: Elife. 2021 Feb 23;10:. (PMID: 33620030)
References: Mol Cell. 2013 Dec 12;52(5):617-28. (PMID: 24239291)
Nat Methods. 2012 Jun 28;9(7):676-82. (PMID: 22743772)
Mol Cell. 2003 Oct;12(4):959-70. (PMID: 14580346)
Biochemistry. 2002 Dec 31;41(52):15505-13. (PMID: 12501179)
Nat Genet. 2013 Sep;45(9):977-83. (PMID: 23852168)
Annu Rev Biochem. 2010;79:321-49. (PMID: 20192758)
Cancers (Basel). 2018 Jul 23;10(7):. (PMID: 30041457)
Cell Host Microbe. 2014 Jul 9;16(1):94-104. (PMID: 24981331)
Bioinformatics. 2009 Jul 15;25(14):1754-60. (PMID: 19451168)
New Phytol. 2014 Sep;203(4):1090-5. (PMID: 25041347)
Nature. 2020 Jul;583(7817):631-637. (PMID: 32641830)
EMBO J. 2002 Jul 15;21(14):3841-51. (PMID: 12110595)
J Antimicrob Chemother. 2019 Feb 1;74(2):298-310. (PMID: 30357339)
J Genet. 2011 Aug;90(2):383-91. (PMID: 21869495)
DNA Repair (Amst). 2003 May 13;2(5):593-608. (PMID: 12713816)
Curr Protoc Mol Biol. 2007 Jul;Chapter 1:Unit 1.17. (PMID: 18265391)
DNA Repair (Amst). 2014 Jul;19:38-47. (PMID: 24746924)
Antimicrob Agents Chemother. 2014 Jun;58(6):3091-9. (PMID: 24637685)
J Struct Biol. 2004 Apr-May;146(1-2):11-31. (PMID: 15037234)
Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7032-7. (PMID: 23572593)
J Biol Chem. 2020 Mar 13;295(11):3497-3505. (PMID: 31996373)
Int J Med Microbiol. 2000 May;290(2):153-65. (PMID: 11045920)
J Bacteriol. 2008 Dec;190(24):7910-7. (PMID: 18849421)
Mol Microbiol. 2006 May;60(4):820-7. (PMID: 16677295)
J Radiat Res. 2009 Jan;50(1):19-26. (PMID: 18987436)
Science. 2010 Apr 23;328(5977):498-501. (PMID: 20413500)
Commun Biol. 2019 Mar 1;2:85. (PMID: 30854477)
Nat Rev Genet. 2013 Dec;14(12):827-39. (PMID: 24166031)
Nat Microbiol. 2018 Apr;3(4):440-446. (PMID: 29459733)
Nucleic Acids Res. 2016 Feb 18;44(3):e28. (PMID: 26429970)
mBio. 2019 May 7;10(3):. (PMID: 31064832)
Methods Enzymol. 1997;276:307-26. (PMID: 27754618)
Wiley Interdiscip Rev Syst Biol Med. 2010 Sep-Oct;2(5):594-602. (PMID: 20836050)
J Biol Chem. 2007 Dec 21;282(51):37103-11. (PMID: 17959604)
Cell. 2015 Oct 22;163(3):607-19. (PMID: 26456113)
Elife. 2017 Mar 21;6:. (PMID: 28323618)
J Bacteriol. 2007 Nov;189(21):7922-6. (PMID: 17827303)
Microbiol Mol Biol Rev. 2007 Mar;71(1):158-229. (PMID: 17347522)
Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2774-83. (PMID: 22991466)
Crit Rev Biochem Mol Biol. 2018 Feb;53(1):29-48. (PMID: 29108429)
Elife. 2017 Aug 18;6:. (PMID: 28820387)
DNA Repair (Amst). 2013 Sep;12(9):699-706. (PMID: 23742752)
J Biol Chem. 2015 Jan 30;290(5):2957-68. (PMID: 25512379)
Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8296-301. (PMID: 27335458)
PLoS Genet. 2017 Jan 23;13(1):e1006582. (PMID: 28114307)
Trends Immunol. 2020 Jul;41(7):586-600. (PMID: 32434680)
Annu Rev Plant Biol. 2014;65:415-42. (PMID: 24471833)
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5. (PMID: 10829079)
Cell Microbiol. 2020 Sep;22(9):e13241. (PMID: 32592518)
Biochim Biophys Acta. 2015 Sep;1847(9):779-85. (PMID: 25585161)
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2176-81. (PMID: 26839411)
Bioinformatics. 2011 Nov 1;27(21):2987-93. (PMID: 21903627)
Mol Microbiol. 2001 Sep;41(5):1101-11. (PMID: 11555290)
Nat Rev Microbiol. 2015 Feb;13(2):83-94. (PMID: 25578955)
Mol Microbiol. 2010 Mar;75(6):1455-67. (PMID: 20132444)
J Bacteriol. 2012 Jan;194(2):243-52. (PMID: 22056936)
Front Microbiol. 2019 May 22;10:952. (PMID: 31191461)
Annu Rev Microbiol. 2015;69:247-63. (PMID: 26253395)
Nat Commun. 2019 Dec 2;10(1):5484. (PMID: 31792213)
G3 (Bethesda). 2011 Aug 1;1(3):183-186. (PMID: 22207905)
Nucleic Acids Res. 2003 Aug 1;31(15):4573-81. (PMID: 12888518)
Front Microbiol. 2015 Jun 05;6:504. (PMID: 26097468)
Virology. 2015 May;479-480:131-45. (PMID: 25818029)
DNA Repair (Amst). 2014 Jul;19:14-26. (PMID: 24780558)
Proc Natl Acad Sci U S A. 2005 May 31;102(22):8006-11. (PMID: 15911752)
Mol Cell. 2010 Oct 22;40(2):179-204. (PMID: 20965415)
Nucleic Acids Res. 2011 Dec;39(22):9473-97. (PMID: 21890906)
Elife. 2021 Jan 15;10:. (PMID: 33448264)
Adv Immunol. 2010;105:159-91. (PMID: 20510733)
Nat Commun. 2019 Aug 9;10(1):3595. (PMID: 31399579)
BMC Genomics. 2016 Jan 05;17:27. (PMID: 26732503)
Nature. 2011 Jul 20;475(7356):343-7. (PMID: 21776080)
Cell. 2000 Nov 22;103(5):711-21. (PMID: 11114328)
Biochemistry. 2008 Jun 17;47(24):6499-507. (PMID: 18500821)
Front Microbiol. 2015 May 19;6:499. (PMID: 26042116)
Genome Res. 2012 Mar;22(3):568-76. (PMID: 22300766)
Mol Plant. 2020 Feb 3;13(2):215-230. (PMID: 31760160)
EMBO J. 2018 May 2;37(9):. (PMID: 29572241)
PLoS Pathog. 2015 Jan 08;11(1):e1004592. (PMID: 25569427)
J Biol Chem. 1998 Aug 14;273(33):21276-81. (PMID: 9694887)
Trends Microbiol. 2020 May;28(5):387-400. (PMID: 32298616)
FEMS Microbiol Rev. 2011 Jul;35(4):652-80. (PMID: 21361996)
Mol Microbiol. 2016 Nov;102(4):690-700. (PMID: 27569113)
J Biol Chem. 2013 Sep 13;288(37):26616-24. (PMID: 23878199)
Genetics. 2011 Sep;189(1):23-36. (PMID: 21705756)
معلومات مُعتمدة: P30 DK089507 United States DK NIDDK NIH HHS; R01 GM128191 United States GM NIGMS NIH HHS; R01 AI080609 United States AI NIAID NIH HHS; United States HHMI Howard Hughes Medical Institute
فهرسة مساهمة: Keywords: Burkholderia; E. coli; evolution; genetics; genomics; infectious disease; microbiology; type vi secretion system
المشرفين على المادة: 0 (Bacterial Proteins)
0 (Bacterial Toxins)
EC 3.5.4.1 (Cytosine Deaminase)
تواريخ الأحداث: Date Created: 20210115 Date Completed: 20220202 Latest Revision: 20220720
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7901873
DOI: 10.7554/eLife.62967
PMID: 33448264
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.62967