دورية أكاديمية
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Evaluation of intravenous to oral antimicrobial switch at a hospital with a tightly regulated antimicrobial stewardship program.

التفاصيل البيبلوغرافية
العنوان: Evaluation of intravenous to oral antimicrobial switch at a hospital with a tightly regulated antimicrobial stewardship program.
المؤلفون: Khumra S; Department of Pharmacy, Austin Health, Melbourne, Victoria, Australia.; Department of Infectious Diseases, Austin Health, Melbourne, Victoria, Australia.; Centre for Medicines Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia., Mahony AA; Department of Infectious Diseases, Austin Health, Melbourne, Victoria, Australia.; Department of Medicine, Melbourne University, Melbourne, Victoria, Australia., Bergen PJ; Centre for Medicines Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.; Department of Microbiology, Monash University, Melbourne, Victoria, Australia., Elliott RA; Department of Pharmacy, Austin Health, Melbourne, Victoria, Australia.; Centre for Medicines Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.
المصدر: British journal of clinical pharmacology [Br J Clin Pharmacol] 2021 Aug; Vol. 87 (8), pp. 3354-3358. Date of Electronic Publication: 2021 Jan 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Wiley-Blackwell
Original Publication: London, Macmillan Journals Ltd.
مواضيع طبية MeSH: Anti-Infective Agents* , Antimicrobial Stewardship*, Adult ; Australia ; Hospitals ; Humans ; Retrospective Studies
مستخلص: Timely intravenous (IV) to oral antimicrobial switch (IV-oral-switch) is a key antimicrobial stewardship (AMS) strategy. We aimed to explore concordance with IV-oral-switch guidelines in the context of a long-standing, tightly regulated AMS program. Data was retrospectively collected for 107 adult general medical and surgical patients in an Australian hospital. Median duration of IV antimicrobial courses before switching to oral therapy was 3 days (interquartile range [IQR] 2.25-5.00). Timely IV-oral-switch occurred in 57% (n = 61) of patients. The median delay to switching was 0 days (IQR 0 to 1.25). In most courses (92/106, 86.8%), the choice of oral alternative after switching was appropriate. In 45% (47/105) of courses, total duration of therapy (IV plus oral) exceeded the recommended duration by >1.0 day. Excessive IV antimicrobial duration was uncommon at a hospital with a tightly regulated AMS program. Total duration of therapy was identified as an AMS target for improvement.
(© 2021 British Pharmacological Society.)
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فهرسة مساهمة: Keywords: antimicrobial stewardship; antimicrobials; guidelines; hospital; preauthoriziation; switch therapy
المشرفين على المادة: 0 (Anti-Infective Agents)
تواريخ الأحداث: Date Created: 20210115 Date Completed: 20211027 Latest Revision: 20211027
رمز التحديث: 20240628
DOI: 10.1111/bcp.14734
PMID: 33450086
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2125
DOI:10.1111/bcp.14734