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Comparison of MRI-based and PET-based image pre-processing for quantification of 11 C-PBB3 uptake in human brain.

التفاصيل البيبلوغرافية
العنوان: Comparison of MRI-based and PET-based image pre-processing for quantification of 11 C-PBB3 uptake in human brain.
المؤلفون: Yousefzadeh-Nowshahr E; Medical Radiation Physics, Department of Nuclear Medicine, Ulm University, Ulm, Germany; Department of Nuclear Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address: elham.yousefzadeh-nowshahr@uni-ulm.de., Winter G; Department of Nuclear Medicine, Ulm University, Ulm, Germany., Bohn P; Department of Nuclear Medicine, Inselspital Bern - University of Bern, Bern, Switzerland., Kneer K; Department of Nuclear Medicine, Ulm University, Ulm, Germany., von Arnim CAF; Department of Neurology, Ulm University, Ulm, Germany; Department of Geriatrics, University Medical Center Göttingen, Göttingen, Germany., Otto M; Department of Neurology, Ulm University, Ulm, Germany., Solbach C; Department of Nuclear Medicine, Ulm University, Ulm, Germany., Anderl-Straub S; Department of Neurology, Ulm University, Ulm, Germany., Polivka D; Department of Neurology, Ulm University, Ulm, Germany., Fissler P; Department of Neurology, Ulm University, Ulm, Germany; Psychiatric Services of Thurgovia (Academic Teaching Hospital of Medical University Salzburg), Münsterlingen, Switzerland., Prasad V; Department of Nuclear Medicine, Ulm University, Ulm, Germany., Kletting P; Medical Radiation Physics, Department of Nuclear Medicine, Ulm University, Ulm, Germany; Department of Nuclear Medicine, Ulm University, Ulm, Germany., Riepe MW; Department of Psychiatry and Psychotherapy II, Ulm University, Ulm, Germany., Higuchi M; National Institute of Radiological Sciences, Chiba, Japan., Ludolph A; Department of Neurology, Ulm University, Ulm, Germany; German Center for Neurodegerative Diseases (DZNE), Ulm, Germany., Beer AJ; Department of Nuclear Medicine, Ulm University, Ulm, Germany., Glatting G; Medical Radiation Physics, Department of Nuclear Medicine, Ulm University, Ulm, Germany; Department of Nuclear Medicine, Ulm University, Ulm, Germany.
المصدر: Zeitschrift fur medizinische Physik [Z Med Phys] 2021 Feb; Vol. 31 (1), pp. 37-47. Date of Electronic Publication: 2021 Jan 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 100886455 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4436 (Electronic) Linking ISSN: 09393889 NLM ISO Abbreviation: Z Med Phys Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: [Heidelberg] : Elsevier GmbH
Original Publication: Jena [Germany] : Gustav Fischer Verlag,
مستخلص: Purpose: Quantification of tau load using 11 C-PBB3-PET has the potential to improve diagnosis of neurodegenerative diseases. Although MRI-based pre-processing is used as a reference method, not all patients have MRI. The feasibility of a PET-based pre-processing for the quantification of 11 C-PBB3 tracer was evaluated and compared with the MRI-based method.
Materials and Methods: Fourteen patients with decreased recent memory were examined with 11 C-PBB3-PET and MRI. The PET scans were visually assessed and rated as either PBB3(+) or PBB3(-). The image processing based on the PET-based method was validated against the MRI-based approach. The regional uptakes were quantified using the Mesial-temporal/Temporoparietal/Rest of neocortex (MeTeR) regions. SUVR values were calculated by normalizing to the cerebellar reference region to compare both methods within the patient groups.
Results: Significant correlations were observed between the SUVRs of the MRI-based and the PET-based methods in the MeTeR regions (r Me =0.91; r Te =0.98; r R =0.96; p<0.0001). However, the Bland-Altman plot showed a significant bias between both methods in the subcortical Me region (bias: -0.041; 95% CI: -0.061 to -0.024; p=0.003). As in the MRI-based method, the 11 C-PBB3 uptake obtained with the PET-based method was higher for the PBB3(+) group in each of the cortical regions and for the whole brain than for the PBB3(-) group (PET-based Global : 1.11 vs. 0.96; Cliff's Delta (d)=0.68; p=0.04; MRI-based Global : 1.11 vs. 0.97; d=0.70; p=0.03). To differentiate between positive and negative scans, Youden's index estimated the best cut-off of 0.99 from the ROC curve with good accuracy (AUC: 0.88±0.10; 95% CI: 0.67-1.00) and the same sensitivity (83%) and specificity (88%) for both methods.
Conclusion: The PET-based pre-processing method developed to quantify the tau burden with 11 C-PBB3 provided comparable SUVR values and effect sizes as the MRI-based reference method. Furthermore, both methods have a comparable discrimination accuracy between PBB3(+) and PBB3(-) groups as assessed by visual rating. Therefore, the presented PET-based method can be used for clinical diagnosis if no MRI image is available.
(Copyright © 2020. Published by Elsevier GmbH.)
فهرسة مساهمة: Keywords: (11)C-PBB3; Pre-processing; Quantification; Tau PET; Template
تواريخ الأحداث: Date Created: 20210117 Latest Revision: 20240724
رمز التحديث: 20240725
DOI: 10.1016/j.zemedi.2020.12.002
PMID: 33454153
قاعدة البيانات: MEDLINE
الوصف
تدمد:1876-4436
DOI:10.1016/j.zemedi.2020.12.002