دورية أكاديمية
Comparison of MRI-based and PET-based image pre-processing for quantification of 11 C-PBB3 uptake in human brain.
العنوان: | Comparison of MRI-based and PET-based image pre-processing for quantification of 11 C-PBB3 uptake in human brain. |
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المؤلفون: | Yousefzadeh-Nowshahr E; Medical Radiation Physics, Department of Nuclear Medicine, Ulm University, Ulm, Germany; Department of Nuclear Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address: elham.yousefzadeh-nowshahr@uni-ulm.de., Winter G; Department of Nuclear Medicine, Ulm University, Ulm, Germany., Bohn P; Department of Nuclear Medicine, Inselspital Bern - University of Bern, Bern, Switzerland., Kneer K; Department of Nuclear Medicine, Ulm University, Ulm, Germany., von Arnim CAF; Department of Neurology, Ulm University, Ulm, Germany; Department of Geriatrics, University Medical Center Göttingen, Göttingen, Germany., Otto M; Department of Neurology, Ulm University, Ulm, Germany., Solbach C; Department of Nuclear Medicine, Ulm University, Ulm, Germany., Anderl-Straub S; Department of Neurology, Ulm University, Ulm, Germany., Polivka D; Department of Neurology, Ulm University, Ulm, Germany., Fissler P; Department of Neurology, Ulm University, Ulm, Germany; Psychiatric Services of Thurgovia (Academic Teaching Hospital of Medical University Salzburg), Münsterlingen, Switzerland., Prasad V; Department of Nuclear Medicine, Ulm University, Ulm, Germany., Kletting P; Medical Radiation Physics, Department of Nuclear Medicine, Ulm University, Ulm, Germany; Department of Nuclear Medicine, Ulm University, Ulm, Germany., Riepe MW; Department of Psychiatry and Psychotherapy II, Ulm University, Ulm, Germany., Higuchi M; National Institute of Radiological Sciences, Chiba, Japan., Ludolph A; Department of Neurology, Ulm University, Ulm, Germany; German Center for Neurodegerative Diseases (DZNE), Ulm, Germany., Beer AJ; Department of Nuclear Medicine, Ulm University, Ulm, Germany., Glatting G; Medical Radiation Physics, Department of Nuclear Medicine, Ulm University, Ulm, Germany; Department of Nuclear Medicine, Ulm University, Ulm, Germany. |
المصدر: | Zeitschrift fur medizinische Physik [Z Med Phys] 2021 Feb; Vol. 31 (1), pp. 37-47. Date of Electronic Publication: 2021 Jan 14. |
نوع المنشور: | Journal Article; Comparative Study |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 100886455 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4436 (Electronic) Linking ISSN: 09393889 NLM ISO Abbreviation: Z Med Phys |
أسماء مطبوعة: | Publication: [Heidelberg] : Elsevier GmbH Original Publication: Jena [Germany] : Gustav Fischer Verlag, |
مواضيع طبية MeSH: | Magnetic Resonance Imaging*/methods , Positron-Emission Tomography*/methods , Brain*/diagnostic imaging , Brain*/metabolism, Humans ; Male ; Female ; Middle Aged ; Aged ; Image Processing, Computer-Assisted/methods ; Carbon Radioisotopes ; Radiopharmaceuticals/pharmacokinetics |
مستخلص: | Purpose: Quantification of tau load using 11 C-PBB3-PET has the potential to improve diagnosis of neurodegenerative diseases. Although MRI-based pre-processing is used as a reference method, not all patients have MRI. The feasibility of a PET-based pre-processing for the quantification of 11 C-PBB3 tracer was evaluated and compared with the MRI-based method. Materials and Methods: Fourteen patients with decreased recent memory were examined with 11 C-PBB3-PET and MRI. The PET scans were visually assessed and rated as either PBB3(+) or PBB3(-). The image processing based on the PET-based method was validated against the MRI-based approach. The regional uptakes were quantified using the Mesial-temporal/Temporoparietal/Rest of neocortex (MeTeR) regions. SUVR values were calculated by normalizing to the cerebellar reference region to compare both methods within the patient groups. Results: Significant correlations were observed between the SUVRs of the MRI-based and the PET-based methods in the MeTeR regions (r Conclusion: The PET-based pre-processing method developed to quantify the tau burden with 11 C-PBB3 provided comparable SUVR values and effect sizes as the MRI-based reference method. Furthermore, both methods have a comparable discrimination accuracy between PBB3(+) and PBB3(-) groups as assessed by visual rating. Therefore, the presented PET-based method can be used for clinical diagnosis if no MRI image is available. (Copyright © 2020. Published by Elsevier GmbH.) |
فهرسة مساهمة: | Keywords: (11)C-PBB3; Pre-processing; Quantification; Tau PET; Template |
المشرفين على المادة: | 0 (Carbon Radioisotopes) 0 (Radiopharmaceuticals) |
تواريخ الأحداث: | Date Created: 20210117 Date Completed: 20240724 Latest Revision: 20240724 |
رمز التحديث: | 20240726 |
DOI: | 10.1016/j.zemedi.2020.12.002 |
PMID: | 33454153 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1876-4436 |
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DOI: | 10.1016/j.zemedi.2020.12.002 |