دورية أكاديمية
أعرض في EDS

Degradable and colloidally stable zwitterionic-functionalized silica nanoparticles.

التفاصيل البيبلوغرافية
العنوان: Degradable and colloidally stable zwitterionic-functionalized silica nanoparticles.
المؤلفون: Schneid AC; Laboratório Nacional de Nanotecnologia (LNNano), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, CEP 13083 970, Brasil.; Laboratório Nacional de Luz Síncrotron (LNLS), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, CEP 13083 970, Brasil., Ribeiro IR; Laboratório Nacional de Nanotecnologia (LNNano), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, CEP 13083 970, Brasil.; Laboratório Nacional de Luz Síncrotron (LNLS), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, CEP 13083 970, Brasil.; Instituto de Química (IQ), Universidade Estadual de Campinas (UNICAMP), Caixa Postal 6154, Campinas, SP, CEP 13083 970, Brasil., Galdino FE; Laboratório Nacional de Nanotecnologia (LNNano), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, CEP 13083 970, Brasil.; Laboratório Nacional de Luz Síncrotron (LNLS), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, CEP 13083 970, Brasil.; Instituto de Química (IQ), Universidade Estadual de Campinas (UNICAMP), Caixa Postal 6154, Campinas, SP, CEP 13083 970, Brasil., Bettini J; Laboratório Nacional de Nanotecnologia (LNNano), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, CEP 13083 970, Brasil., Cardoso MB; Laboratório Nacional de Nanotecnologia (LNNano), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, CEP 13083 970, Brasil.; Laboratório Nacional de Luz Síncrotron (LNLS), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, CEP 13083 970, Brasil.; Instituto de Química (IQ), Universidade Estadual de Campinas (UNICAMP), Caixa Postal 6154, Campinas, SP, CEP 13083 970, Brasil.
المصدر: Nanomedicine (London, England) [Nanomedicine (Lond)] 2021 Jan; Vol. 16 (2), pp. 85-96. Date of Electronic Publication: 2021 Jan 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Future Medicine Ltd Country of Publication: England NLM ID: 101278111 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-6963 (Electronic) Linking ISSN: 17435889 NLM ISO Abbreviation: Nanomedicine (Lond) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London, UK : Future Medicine Ltd., c2006-
مواضيع طبية MeSH: Nanoparticles* , Silicon Dioxide*, Silanes
مستخلص: Aim: This work is focused on obtaining degradable mesoporous silica nanoparticles (DMSNs) which are able to maintain their colloidal stability in complex biological media. Materials & methods: DMSNs were synthesized using different ratios of disulfide organosilane (degradable structural moiety) and further functionalized with sulfobetaine silane (SBS) to enhance colloidal stability and improve biological compatibility. Results: There was a clear trade-off between nanoparticle degradability and colloidal stability, since full optimization of the degradation process generated unstable particles, while enhancing colloidal stability resulted in poor DMSNs degradation. It was also shown that acidic pH improved particle degradation which is commonly triggered by reduction stimulus. Conclusion: A chemical composition window was found where DMSNs presented satisfactory colloidal stability in biologically relevant medium, meaningful degradation profiles and high biocompatibility.
فهرسة مساهمة: Keywords: biocompatibility; biological environment; colloidal stability; degradability; degradable mesoporous silica nanoparticles
المشرفين على المادة: 0 (Silanes)
7631-86-9 (Silicon Dioxide)
تواريخ الأحداث: Date Created: 20210119 Date Completed: 20210728 Latest Revision: 20210728
رمز التحديث: 20221213
DOI: 10.2217/nnm-2020-0257
PMID: 33463385
قاعدة البيانات: MEDLINE
الوصف
تدمد:1748-6963
DOI:10.2217/nnm-2020-0257