دورية أكاديمية
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Chemopreventive Effect of 5-Flurouracil Polymeric Hybrid PLGA-Lecithin Nanoparticles against Colon Dysplasia Model in Mice and Impact on p53 Apoptosis.

التفاصيل البيبلوغرافية
العنوان: Chemopreventive Effect of 5-Flurouracil Polymeric Hybrid PLGA-Lecithin Nanoparticles against Colon Dysplasia Model in Mice and Impact on p53 Apoptosis.
المؤلفون: A Attia M; Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.; Department of Pharmacology, College of Medicine, AlMaarefa University, Riyadh 11597, Saudi Arabia., Enan ET; Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt., Hashish AA; Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt.; Basic Medical Sciences Department, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia., M H El-Kannishy S; Department of Toxicology, Mansoura Hospital, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia., Gardouh AR; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.; Department of Pharmacy, Faculty of Pharmacy, Jadara University, Irbid 21110, Jordan., K Tawfik M; Department of Clinical Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt., Faisal S; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt., El-Mistekawy A; Department of Internal Medicine, Gastroenterology Division, Faculty of Medicine, Al-Azhar University, Cairo 11651, Egypt., Salama A; Department of Pharmaceutics, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11751, Egypt., Alomar SY; Doping Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh 11495, Saudi Arabia., H Eltrawy A; Department of Anatomy and Embryology, Faculty of Medicine, Alexandria University, Alexandria 22785, Egypt., Yagub Aloyouni S; Health Sciences Research Center, Princess Nourah Bint Abdulrahman University, Riyadh 84428, Saudi Arabia., Zaitone SA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
المصدر: Biomolecules [Biomolecules] 2021 Jan 15; Vol. 11 (1). Date of Electronic Publication: 2021 Jan 15.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, 2011-
مواضيع طبية MeSH: Chemoprevention*, Fluorouracil/*pharmacology , Lecithins/*chemistry , Nanoparticles/*chemistry , Polylactic Acid-Polyglycolic Acid Copolymer/*chemistry , Polymers/*chemistry, Animals ; Apoptosis ; Colon/drug effects ; Colon/pathology ; Disease Models, Animal ; Drug Liberation ; Ki-67 Antigen/metabolism ; Lipids/chemistry ; Male ; Mice ; Particle Size ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Static Electricity ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
مستخلص: The use of 5-fluorouracil (5FU) is associated with multifaceted challenges and poor pharmacokinetics. Poly(lactic-co-glycolic acid)-lipid hybrid nanoparticles (PLNs)-based therapy has received attention as efficient carriers for a diversity of drugs. This study evaluated the in vivo chemotherapeutic and anti-proliferative efficacy of 5FU-loaded PLNs against 1,2-dimethylhydrazine (Di-MH) prompted colon dysplasia in mice compared to free 5FU. 5FU PLNs were prepared. Male Swiss albino mice were distributed to six experimental groups. Group 1: Saline group. All the other groups were injected weekly with Di-MH [20 mg/kg, s.c.]. Group 2: Di-MH induced colon dysplasia control group. Groups 3 and 4: Di-MH + free 5FU treated group [2.5 and 5 mg/kg]. Groups 5 and 6: Di-MH + 5FU-PLNs treated group [2.5 and 5 mg/kg]. Free 5FU and 5FU-PLNs doses were administered orally, twice weekly. Treatment with 5FU-PLNs induced a higher cytoprotective effect compared to free 5FU as indicated by lower mucosal histopathologic score and reduction in number of Ki-67 immunpositive proliferating nuclei. Additionally, there was significant upregulation of p53 and caspase 3 genes in colon specimens. Our results support the validity of utilizing the PLNs technique to improve the chemopreventive action of 5FU in treating colon cancer.
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فهرسة مساهمة: Keywords: 5-flurouracil; PLGA-lecithin; apoptosis; experimental colon dysplasia; mouse; polymeric lipid hybrid nanoparticles
المشرفين على المادة: 0 (Ki-67 Antigen)
0 (Lecithins)
0 (Lipids)
0 (Polymers)
0 (RNA, Messenger)
0 (Tumor Suppressor Protein p53)
1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
U3P01618RT (Fluorouracil)
تواريخ الأحداث: Date Created: 20210120 Date Completed: 20210623 Latest Revision: 20210623
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7830948
DOI: 10.3390/biom11010109
PMID: 33467560
قاعدة البيانات: MEDLINE
الوصف
تدمد:2218-273X
DOI:10.3390/biom11010109