دورية أكاديمية
أعرض في EDS

Improvement in Quality of Life Following Surgical Resection of Benign Intradural Extramedullary Tumors: A Prospective Evaluation of Patient-Reported Outcomes.

التفاصيل البيبلوغرافية
العنوان: Improvement in Quality of Life Following Surgical Resection of Benign Intradural Extramedullary Tumors: A Prospective Evaluation of Patient-Reported Outcomes.
المؤلفون: Newman WC; Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana., Berry-Candelario J; UMass Memorial Health Care, Boston, Massachusetts., Villavieja J; Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Reiner AS; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Bilsky MH; Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Neurological Surgery, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York., Laufer I; Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Neurological Surgery, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York., Barzilai O; Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
المصدر: Neurosurgery [Neurosurgery] 2021 Apr 15; Vol. 88 (5), pp. 989-995.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins, Inc Country of Publication: United States NLM ID: 7802914 Publication Model: Print Cited Medium: Internet ISSN: 1524-4040 (Electronic) Linking ISSN: 0148396X NLM ISO Abbreviation: Neurosurgery Subsets: MEDLINE
أسماء مطبوعة: Publication: 2022- : [Philadelphia] : Lippincott Williams & Wilkins, Inc.
Original Publication: Baltimore, Williams & Wilkins.
مواضيع طبية MeSH: Patient Reported Outcome Measures* , Quality of Life*, Nerve Sheath Neoplasms/*surgery , Spinal Cord Neoplasms/*surgery, Humans ; Laminectomy/adverse effects ; Laminectomy/statistics & numerical data ; Postoperative Complications ; Prospective Studies ; Treatment Outcome
مستخلص: Background: Historically, symptomatic, benign intradural extramedullary (IDEM) spine tumors have been managed with surgical resection. However, minimal robust data regarding patient-reported outcomes (PROs) following treatment of symptomatic lesions exists. Moreover, there are increasing reports of radiosurgical management of these lesions without robust health-related quality of life data.
Objective: To prospectively analyze PROs among patients with benign IDEM spine tumors undergoing surgical resection to define the symptomatic efficacy of surgery.
Methods: Prospective, single-center observational cohort study of patients with benign IDEM spine tumors undergoing open surgical resection. Pre- and postoperative Brief Pain Index (BPI) and MD Anderson Symptom Inventory (MDASI) questionnaires were used to quantitatively assess their symptom control after surgical intervention. Matched pairs were analyzed with the Wilcoxon signed-rank test.
Results: A total of 57 patients met inclusion criteria with both pre- and postoperative PROs. There were 35 schwannomas, 18 meningiomas, 2 neurofibromas, 1 paraganglioma, and 1 mixed schwannoma/neurofibroma. Most patients were American Spinal Injury Association Impairment (ASIA) E (93%) with high-grade spinal cord compression (77%), and underwent either a 2 or 3 level laminectomy (84%). Surgical resection resulted in statistically significant improvement in all 3 composite BPI constructs of pain-severity, pain-interference, and overall patient pain experience (P < .0001). Surgical resection resulted in statistically significant improvements in all composite scores for the MDASI core symptom severity, spine tumor, and disease interference constructs (P < .01). Three patients (5%) had postoperative complications requiring surgical interventions (2 wound revisions and 1 ventriculo-peritoneal shunt).
Conclusion: Surgical resection of IDEM spine tumors provides rapid, significant, and durable improvement in PROs.
(© Congress of Neurological Surgeons 2021.)
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معلومات مُعتمدة: P30 CA008748 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: Intradural extramedullary spine tumors; Patient-reported outcomes; Quality of life; Spinal cord compression
تواريخ الأحداث: Date Created: 20210120 Date Completed: 20210702 Latest Revision: 20220120
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8046588
DOI: 10.1093/neuros/nyaa561
PMID: 33469658
قاعدة البيانات: MEDLINE
الوصف
تدمد:1524-4040
DOI:10.1093/neuros/nyaa561