دورية أكاديمية
Screening for PIK3CA mutations among Saudi women with ovarian cancer.
| العنوان: | Screening for PIK3CA mutations among Saudi women with ovarian cancer. |
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| المؤلفون: | Al-Qahtani WS; Department of Forensic Sciences, College of Criminal Justice, Naif Arab University of Security Sciences, Riyadh, Saudi Arabia., Alduwish MA; Department of Biology, College of Science and Humanities, Prince Sattam bin Abdulaziz University, Alkarj, Saudi Arabia., Al-Olayan EM; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia., Aljarba NH; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Em AH; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Albani FG; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Domiaty DM; Department of Biology, College of Science, University of Jeddah, Jeddah, Saudi Arabia., Al-Otaibi AM; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Qattan SMA; King Faisal Specialist Hospital and Research Center (KFSHRC), Riyadh, Saudi Arabia., Almurshedi AS; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Elasbali AM; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Qurayyat, Saudi Arabia., Ahmed HG; College of Medicine, University of Hail, Hail, Saudi Arabia.; Molecular Diagnostics and Personalized Therapeutics Unit, University of Ha'il, Hail, Saudi Arabia.; Department of Histopathology and Cytology, FMLS, University of Khartoum, Khartoum, Sudan., Almutlaq BA; College of Medicine, University of Hail, Hail, Saudi Arabia. |
| المصدر: | Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology [J Obstet Gynaecol] 2021 Oct; Vol. 41 (7), pp. 1127-1133. Date of Electronic Publication: 2021 Jan 21. |
| نوع المنشور: | Evaluation Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8309140 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1364-6893 (Electronic) Linking ISSN: 01443615 NLM ISO Abbreviation: J Obstet Gynaecol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: [Bristol, England] : Wright, PSG, |
| مواضيع طبية MeSH: | Arabs/*genetics , Carcinoma, Ovarian Epithelial/*genetics , Class I Phosphatidylinositol 3-Kinases/*genetics , Ovarian Neoplasms/*genetics, Adult ; Biomarkers, Tumor/genetics ; Carcinoma, Ovarian Epithelial/ethnology ; DNA Mutational Analysis ; Exons ; Female ; Humans ; Middle Aged ; Mutation, Missense/genetics ; Ovarian Neoplasms/ethnology ; Prognosis ; Retrospective Studies ; Saudi Arabia |
| مستخلص: | The study aimed to screen for PIK3CA gene mutations among Saudi women with Ovarian Cancer. The study included 298 Saudi women with epithelial ovarian cancers (EOC). DNA sequence analysis was employed to screen for the mutations. DNA sequence analysis of a coding region of exon 9 and 20 of PIK3CA gene revealed mutations in 37/298 (12.4%) EOC patients. About 21/37(56.8%) somatic mutations were identified in exons 9, and 16/37(43.2%) in exon 20. All analysed mutations were missense mutations, the frequencies of which varied from 2.7% to 43.2%. PIK3CA mutation was found to be significantly associated with age ( p = .023), grade ( p = .001) and histological types ( p = .032). Only 6.6% of serous carcinomas and 3.8% of endometrioid had PIK3CA mutation. The Mutated PIK3CA gene was significantly involved in the pathogenesis of EOC among Saudi women. PIK3CA gene mutation and overexpression represent important clinical implications for diagnosis, and prognosis, which can be utilised for better EOC management.Impact statement What is already known on this subject? The detailed molecular and genetic phenomenon underlying the progression of these tumours is still unclear. Recently, the pathogenesis of ovarian cancer has been attributed to mutations of PIK3CA. What do the results of this study add? Mutation in the PIK3CA gene leads to altered PI3K/AKT signalling pathways responsible for the progression of the epithelial ovarian cancer. What are the implications of these findings for clinical practice and/or further research? The Mutated PIK3CA gene was significantly involved in the pathogenesis of EOC among Saudi women. PIK3CA gene mutation and overexpression represent important clinical implications for diagnosis, and prognosis, which can be utilised for better EOC management. |
| فهرسة مساهمة: | Keywords: Epithelial ovarian cancer; FIGO stage; Kaplan-Meier survival analyses; PIK3CA mutation; Saudi Arabia; p110α expression |
| المشرفين على المادة: | 0 (Biomarkers, Tumor) EC 2.7.1.137 (Class I Phosphatidylinositol 3-Kinases) EC 2.7.1.137 (PIK3CA protein, human) |
| تواريخ الأحداث: | Date Created: 20210121 Date Completed: 20220106 Latest Revision: 20220106 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/01443615.2020.1839871 |
| PMID: | 33475035 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1364-6893 |
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| DOI: | 10.1080/01443615.2020.1839871 |