دورية أكاديمية
Mechanisms of Dietary Sodium-Induced Impairments in Endothelial Function and Potential Countermeasures.
العنوان: | Mechanisms of Dietary Sodium-Induced Impairments in Endothelial Function and Potential Countermeasures. |
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المؤلفون: | Patik JC; Department of Kinesiology and Applied Physiology, University of Delaware, 540 S College Ave., Newark, DE 19713, USA., Lennon SL; Department of Kinesiology and Applied Physiology, University of Delaware, 540 S College Ave., Newark, DE 19713, USA., Farquhar WB; Department of Kinesiology and Applied Physiology, University of Delaware, 540 S College Ave., Newark, DE 19713, USA., Edwards DG; Department of Kinesiology and Applied Physiology, University of Delaware, 540 S College Ave., Newark, DE 19713, USA. |
المصدر: | Nutrients [Nutrients] 2021 Jan 19; Vol. 13 (1). Date of Electronic Publication: 2021 Jan 19. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI Publishing |
مواضيع طبية MeSH: | Endothelial Cells/*physiology , Endothelium, Vascular/*physiology , Sodium, Dietary/*adverse effects, Animals ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/prevention & control ; Exercise ; Glycocalyx/physiology ; Humans ; Nitric Oxide/metabolism ; Oxidative Stress ; Potassium, Dietary ; Reactive Oxygen Species/metabolism |
مستخلص: | Despite decades of efforts to reduce sodium intake, excess dietary sodium remains commonplace, and contributes to increased cardiovascular morbidity and mortality independent of its effects on blood pressure. An increasing amount of research suggests that high-sodium diets lead to reduced nitric oxide-mediated endothelial function, even in the absence of a change in blood pressure. As endothelial dysfunction is an early step in the progression of cardiovascular diseases, the endothelium presents a target for interventions aimed at reducing the impact of excess dietary sodium. In this review, we briefly define endothelial function and present the literature demonstrating that excess dietary sodium results in impaired endothelial function. We then discuss the mechanisms through which sodium impairs the endothelium, including increased reactive oxygen species, decreased intrinsic antioxidant defenses, endothelial cell stiffening, and damage to the endothelial glycocalyx. Finally, we present selected research findings suggesting that aerobic exercise or increased intake of dietary potassium may counteract the deleterious vascular effects of a high-sodium diet. |
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معلومات مُعتمدة: | P20 GM113125 United States GM NIGMS NIH HHS; R01HL145055 United States HL NHLBI NIH HHS; R01 HL145055 United States HL NHLBI NIH HHS; 20POST35080171 American Heart Association; R01HL104106 United States HL NHLBI NIH HHS; P20GM113125 United States GM NIGMS NIH HHS |
فهرسة مساهمة: | Keywords: aerobic exercise; dietary sodium; endothelium oxidative stress; glycocalyx; high salt; nitric oxide; potassium |
المشرفين على المادة: | 0 (Potassium, Dietary) 0 (Reactive Oxygen Species) 0 (Sodium, Dietary) 31C4KY9ESH (Nitric Oxide) |
تواريخ الأحداث: | Date Created: 20210122 Date Completed: 20210901 Latest Revision: 20210901 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC7832854 |
DOI: | 10.3390/nu13010270 |
PMID: | 33477837 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2072-6643 |
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DOI: | 10.3390/nu13010270 |