دورية أكاديمية
Resistance mesenteric arteries display hypercontractility in the resolution time of Strongyloides venezuelensis infection.
| العنوان: | Resistance mesenteric arteries display hypercontractility in the resolution time of Strongyloides venezuelensis infection. |
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| المؤلفون: | Dela Justina V; Institute of Biological Sciences, Federal University of Goias, Goiânia, GO, Brazil., Gama LA; Institute of Biological Sciences and Health, Federal University of Mato Grosso, Barra Do Garças, MT, Brazil; Institute of Biosciences, São Paulo State University - UNESP, Botucatu, SP, Brazil., Schönholzer T; Institute of Biological Sciences and Health, Federal University of Mato Grosso, Barra Do Garças, MT, Brazil., Bressan AF; Institute of Biological Sciences and Health, Federal University of Mato Grosso, Barra Do Garças, MT, Brazil; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Lima VV; Institute of Biological Sciences and Health, Federal University of Mato Grosso, Barra Do Garças, MT, Brazil., Americo MF; Institute of Biological Sciences and Health, Federal University of Mato Grosso, Barra Do Garças, MT, Brazil; Institute of Biosciences, São Paulo State University - UNESP, Botucatu, SP, Brazil., Giachini FR; Institute of Biological Sciences, Federal University of Goias, Goiânia, GO, Brazil; Institute of Biological Sciences and Health, Federal University of Mato Grosso, Barra Do Garças, MT, Brazil. Electronic address: fernandagiachini@hotmail.com. |
| المصدر: | Experimental parasitology [Exp Parasitol] 2021 Mar; Vol. 222, pp. 108078. Date of Electronic Publication: 2021 Jan 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0370713 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2449 (Electronic) Linking ISSN: 00144894 NLM ISO Abbreviation: Exp Parasitol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Orlando, FL : Academic Press Original Publication: New York. |
| مواضيع طبية MeSH: | Endothelial Cells/*physiology , Intestines/*blood supply , Mesenteric Arteries/*physiopathology , Strongyloides/*physiology , Strongyloidiasis/*physiopathology, Animals ; Feces/parasitology ; Female ; Gerbillinae ; Male ; Muscle Contraction ; Neglected Diseases/physiopathology ; Parasite Egg Count ; Random Allocation ; Rats ; Rats, Wistar |
| مستخلص: | The blood flow in the mesenteric region is crucial for nutrient absorption and immune response in the gastrointestinal tract. The presence of nematodes or their excreted/secreted products seems to provoke vascular dysfunction. However, it is unclear whether and how the intestinal nematodes with habitat in the intestinal niche could affect the mesenteric vascular resistance. In this study, male Wistar rats were infected with 2000 larvae of S. venezuelensis, and experiments were conducted at 0 (non-infected control), 10 or 30 days post-infection (DPI). Eggs were counted in rats' feces and adult worms recovered from the small intestine. Second- or third-order mesenteric arteries were extracted for concentration-response curves (CRC) to phenylephrine [PE; in the presence or absence of L-NAME or indomethacin] and acetylcholine. The number of eggs and adult worms were significantly higher in the 10 DPI group than those of 30 DPI group. Augmented PE-induced contraction was seen after 30 DPI compared to 10 DPI or control group. Hypercontractility to PE was partially prevented by L-NAME and wholly abolished by indomethacin incubation. Endothelium-dependent relaxation and endothelial nitric oxide synthase expression were unchanged among groups. COX-1 and COX-2 display a different pattern of expression over the infection. Hypercontractility observed in mesenteric resistance arteries in the resolution time of S. venezuelensis infection may represent systemic damage, which can generate significant cardiovascular and gastrointestinal repercussions. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: COX; Intestinal parasites; Prostaglandins; eNOS |
| تواريخ الأحداث: | Date Created: 20210124 Date Completed: 20210223 Latest Revision: 20210223 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.exppara.2021.108078 |
| PMID: | 33485874 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1090-2449 |
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| DOI: | 10.1016/j.exppara.2021.108078 |