دورية أكاديمية
A Pilot Study to Examine Psychological and Neuropsychological Outcomes and a Novel Detoxification Program for Gulf War Illness.
| العنوان: | A Pilot Study to Examine Psychological and Neuropsychological Outcomes and a Novel Detoxification Program for Gulf War Illness. |
|---|---|
| المؤلفون: | Graves DF; Psychology Department, Russell Sage College, Troy, NY 12181, USA., Morse GS; Psychology Department, Russell Sage College, Troy, NY 12181, USA.; Institute for Health & the Environment, University at Albany, Albany, NY 12144, USA., Kerr K; Department of Family & Community Medicine, University of Toronto, Toronto, ON M5G 1V7, Canada., Carpenter DO; Department of Environmental Health Sciences, University at Albany, Albany, NY 12144, USA.; Institute for Health & the Environment, University at Albany, Albany, NY 12144, USA. |
| المصدر: | Military medicine [Mil Med] 2021 Jan 25; Vol. 186 (Suppl 1), pp. 205-213. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 2984771R Publication Model: Print Cited Medium: Internet ISSN: 1930-613X (Electronic) Linking ISSN: 00264075 NLM ISO Abbreviation: Mil Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : Oxford : Oxford University Press Original Publication: Washington, D.C. : Association of Military Surgeons, United States, 1955- |
| مواضيع طبية MeSH: | Military Personnel* , Persian Gulf Syndrome* , Veterans*, Adult ; Aged ; Female ; Gulf War ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Pilot Projects |
| مستخلص: | Introduction: Exposures to environmental toxins have been associated with severe health problems for approximately one-quarter of the nearly 700,000 U.S. soldiers who served in the Gulf War between the years 1990 and 1991. Gulf War illness still affects about 30% of Gulf War veterans (GWV), causing reduced psychological wellness and neuropsychological function. Method and Materials: This pilot study used a randomized wait-list control design to explore the feasibility and efficacy of a novel detoxification method for GWV exposed to toxicants such as pesticides, nerve gases, and pyridostigmine bromide. Our study included 32 GWV (67% male), with a mean age of 51 (range: 43-70, SD = 6.97), who participated in a 4- to 5-week treatment that was hypothesized to reduce the reported psychological and neuropsychological symptoms. Psychological measures used included tests given for the evaluation of neurocognitive function, including motor function for a dominant hand with the grooved pegboard test; verbal and visual immediate and delayed memory with the Wechsler Memory Scale III abbreviated subtests; executive function domains of attention, speed, and mental flexibility with trail making test parts A and B and Stroop color and word test. Psychological status was measured using the nine subscales of the Symptom Checklist-90-Revised. Results: Primary outcomes included between-group differences in self-reported psychological measures and a neuropsychological battery at 7-day and 3-month assessments. Baseline comparison revealed improvements in 16 of 19 psychological and neuropsychological measures at 7-day assessment and that 13 remained stable at 3-month assessment. Conclusions: We conclude that the detoxification procedure provided improvement in psychological and cognitive function for GWV and that future study is warranted. (© The Association of Military Surgeons of the United States 2021. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| سلسلة جزيئية: | ClinicalTrials.gov NCT01672710 |
| تواريخ الأحداث: | Date Created: 20210127 Date Completed: 20210416 Latest Revision: 20210416 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1093/milmed/usaa486 |
| PMID: | 33499551 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1930-613X |
|---|---|
| DOI: | 10.1093/milmed/usaa486 |