دورية أكاديمية
The effect of topiramate versus flunarizine on the non-headache symptoms of migraine.
| العنوان: | The effect of topiramate versus flunarizine on the non-headache symptoms of migraine. |
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| المؤلفون: | Li W; Department of Neurosurgery, Liaocheng Brain Hospital, Liaocheng, Shandong Province, China., Liu R; Department of Neurology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China., Liu W; Department of Neurosurgery, Liaocheng Brain Hospital, Liaocheng, Shandong Province, China., Li G; Department of Neurology, Liaocheng Third People's Hospital, Liaocheng, Shandong Province, China., Chen C; Department of Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.; Department of Neurology, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, Shandong, China. |
| المصدر: | The International journal of neuroscience [Int J Neurosci] 2023 Jan; Vol. 133 (1), pp. 19-25. Date of Electronic Publication: 2021 Feb 10. |
| نوع المنشور: | Randomized Controlled Trial; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 0270707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1563-5279 (Electronic) Linking ISSN: 00207454 NLM ISO Abbreviation: Int J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: New York, Gordon and Breach. |
| مواضيع طبية MeSH: | Flunarizine*/therapeutic use , Migraine Disorders*/drug therapy, Humans ; Topiramate/therapeutic use ; Fructose/therapeutic use ; Headache ; Dopamine |
| مستخلص: | Objectives: To investigate the impact of topiramate versus flunarizine on the non-headache symptoms (NHS) of migraine, and to observe the changes of dopamine (DA) and prolactin (PRL) before and after prophylactic treatment. Methods: Sixty-six episodic migraine patients were enrolled and randomized 1:1 to receive either flunarizine or topiramate treatment. Clinical characteristics and NHS associated with migraine were investigated before and after prophylactic treatment. The DA and PRL levels were also determined before and after prophylactic treatment. Results: The NHS of migraine in the two groups were significantly better after treatment than before treatment in premonitory phase (PP), headache phase (HP), and resolution phase (RP). The NHS in the two groups had no significant difference in PP, HP, and RP before and after treatment. In the flunarizine group, the PRL content after treatment was significantly higher than that before treatment ( t = -4.097, p < 0.001), but the DA content was decreased slightly compared with that before treatment ( t = 1.909, p = 0.066). There was no significant difference in PRL content ( t = 1.099, p = 0.280) and DA content ( t = 1.556, p = 0.130) in topiramate group before and after treatment. Conclusions: The two classical prophylactic drugs of migraine were significantly effective in treating the NHS of migraine, but there was no significant difference between the two drugs. The DA-PRL axis may be involved in the underlying mechanism of the flunarizine treatment for the NHS of migraine. |
| فهرسة مساهمة: | Keywords: Migraine; dopamine; flunarizine; non-headache symptoms; prolactin; topiramate |
| المشرفين على المادة: | 0H73WJJ391 (Topiramate) R7PLA2DM0J (Flunarizine) 30237-26-4 (Fructose) VTD58H1Z2X (Dopamine) |
| تواريخ الأحداث: | Date Created: 20210127 Date Completed: 20230126 Latest Revision: 20230202 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/00207454.2021.1881091 |
| PMID: | 33499714 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1563-5279 |
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| DOI: | 10.1080/00207454.2021.1881091 |