دورية أكاديمية
أعرض في EDS

CDK2 limits the highly energetic secretory program of mature β cells by restricting PEP cycle-dependent K ATP channel closure.

التفاصيل البيبلوغرافية
العنوان: CDK2 limits the highly energetic secretory program of mature β cells by restricting PEP cycle-dependent K ATP channel closure.
المؤلفون: Sdao SM; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA., Ho T; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA., Poudel C; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA., Foster HR; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA., De Leon ER; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA., Adams MT; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA., Lee JH; Cell Growth and Metabolism Section, Diabetes, Endocrinology, and Obesity Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA., Blum B; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA., Rane SG; Cell Growth and Metabolism Section, Diabetes, Endocrinology, and Obesity Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA., Merrins MJ; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA. Electronic address: mmerrins@medicine.wisc.edu.
المصدر: Cell reports [Cell Rep] 2021 Jan 26; Vol. 34 (4), pp. 108690.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: B-Lymphocytes/*metabolism , Cyclin-Dependent Kinase 2/*therapeutic use , KATP Channels/*drug effects, Animals ; Cyclin-Dependent Kinase 2/pharmacology ; Humans ; Mice
مستخلص: Hallmarks of mature β cells are restricted proliferation and a highly energetic secretory state. Paradoxically, cyclin-dependent kinase 2 (CDK2) is synthesized throughout adulthood, its cytosolic localization raising the likelihood of cell cycle-independent functions. In the absence of any changes in β cell mass, maturity, or proliferation, genetic deletion of Cdk2 in adult β cells enhanced insulin secretion from isolated islets and improved glucose tolerance in vivo. At the single β cell level, CDK2 restricts insulin secretion by increasing K ATP conductance, raising the set point for membrane depolarization in response to activation of the phosphoenolpyruvate (PEP) cycle with mitochondrial fuels. In parallel with reduced β cell recruitment, CDK2 restricts oxidative glucose metabolism while promoting glucose-dependent amplification of insulin secretion. This study provides evidence of essential, non-canonical functions of CDK2 in the secretory pathways of quiescent β cells.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 DK113103 United States DK NIDDK NIH HHS; R21 AG050135 United States AG NIA NIH HHS; R01 DK121706 United States DK NIDDK NIH HHS; K01 DK101683 United States DK NIDDK NIH HHS; R01 AG062328 United States AG NIA NIH HHS; R01 DK127637 United States DK NIDDK NIH HHS; T32 AG000213 United States AG NIA NIH HHS; T32 GM007133 United States GM NIGMS NIH HHS; T32 GM008349 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: CDK2; K(ATP) channel; PEP cycle; amplifying pathways; biosensor imaging; calcium; electrophysiology; insulin secretion; metabolic oscillations; β cell metabolism
المشرفين على المادة: 0 (KATP Channels)
EC 2.7.11.22 (Cyclin-Dependent Kinase 2)
تواريخ الأحداث: Date Created: 20210127 Date Completed: 20220128 Latest Revision: 20220907
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7882066
DOI: 10.1016/j.celrep.2021.108690
PMID: 33503433
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2021.108690