دورية أكاديمية
Assessment of the biological potential of diaryltriazene-derived triazene compounds.
العنوان: | Assessment of the biological potential of diaryltriazene-derived triazene compounds. |
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المؤلفون: | Figueirêdo PMS; Laboratório de Microbiologia Clínica, Federal University of Maranhão (UFMA), São Luís, MA, 65.080-040, Brazil., Sampaio Filho JC; Electrochemistry and Biotechnology Laboratory (EBL), University of CEUMA (UNICEUMA), São Luís, MA, 65.065-470, Brazil., Sodré AJS; Laboratório de Microbiologia Clínica, Federal University of Maranhão (UFMA), São Luís, MA, 65.080-040, Brazil., de Castro Júnior JR; Laboratório de Microbiologia Clínica, Federal University of Maranhão (UFMA), São Luís, MA, 65.080-040, Brazil., Gonçalves IS; Electrochemistry and Biotechnology Laboratory (EBL), University of CEUMA (UNICEUMA), São Luís, MA, 65.065-470, Brazil., Blasques RV; Department of Nature Sciences, Mathematics, and Education, Federal University of São Carlos, Araras, SP, 13.600-970, Brazil., S Correa R; Instituto de Ciências Exatas e Biológicas (ICEB), Federal University of Ouro Preto (UFOP), Ouro Preto, MG, 35.400-000, Brazil., Lima BAV; Licenciatura em Ciências Naturais, Federal University of Maranhão (UFMA), Grajaú, MA, 65.940-000, Brazil., Dos Anjos Marques L; Laboratório de Microbiologia Clínica, Federal University of Maranhão (UFMA), São Luís, MA, 65.080-040, Brazil., Coutinho DF; Laboratório de Farmacognosia, Federal University of Maranhão (UFMA), São Luís, MA, 65.080-040, Brazil., de Azevedo Dos Santos APS; Laboratório de Imunologia Aplicada ao Câncer (LIAC), Federal University of Maranhão (UFMA), São Luís, MA, 65.080-040, Brazil., Luz TRSA; Laboratório de Farmacognosia, Federal University of Maranhão (UFMA), São Luís, MA, 65.080-040, Brazil., de Miranda RCM; Electrochemistry and Biotechnology Laboratory (EBL), University of CEUMA (UNICEUMA), São Luís, MA, 65.065-470, Brazil., Dos Santos JRA; Laboratory of Environmental Microbiology, University of CEUMA (UNICEUMA), São Luís, MA, 65.065-470, Brazil., Doriguetto AC; Institute of Chemistry, Federal University of Alfenas (UNIFAL), Alfenas, MG, 37.130-001, Brazil., Pividori MI; Grup de Sensors i Biosensors, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain., Hörner M; Department of Chemistry, Federal University of Santa Maria (UFSM), Santa Maria, RS, 97.110-900, Brazil., Villis PCM; Electrochemistry and Biotechnology Laboratory (EBL), University of CEUMA (UNICEUMA), São Luís, MA, 65.065-470, Brazil. paulo.villis@ceuma.br. |
المصدر: | Scientific reports [Sci Rep] 2021 Jan 28; Vol. 11 (1), pp. 2541. Date of Electronic Publication: 2021 Jan 28. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Triazenes/*chemistry , Triazenes/*pharmacology, Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Structure-Activity Relationship |
مستخلص: | In the present study, novel, 1,3-diaryltriazene-derived triazene compounds were synthesized and tested. Triazenes are versatile and belong to a group of alkylating agents with interesting physicochemical properties and proven biological activities. This study describes the synthesis, molecular and crystalline structure, biological activity evaluation, and antifungal and antimicrobial potentials of 1,3-bis(X-methoxy-Y-nitrophenyl)triazenes [X = 2 and 5; Y = 4 and 5]. The antimicrobial and antifungal activities of the compounds were tested by evaluating the sensitivity of bacteria (American Type Culture Collection, ATCC) and clinical isolates to their solutions using standardized microbiological assays, cytotoxicity evaluation, and ecotoxicity tests. The antimicrobial potentials of triazenes were determined according to their minimum inhibitory concentrations (MICs); these compounds were active against gram-positive and gram-negative bacteria, with low MIC values. The most surprising result was obtained for T3 having the effective MIC of 9.937 µg/mL and antifungal activity against Candida albicans ATCC 90028, C. parapsilosis ATCC 22019, and C. tropicallis IC. To the best of our knowledge, this study is the first to report promising activities of triazene compounds against yeast and filamentous fungi. The results showed the potential utility of triazenes as agents affecting selected resistant bacterial and fungal strains. |
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المشرفين على المادة: | 0 (Anti-Infective Agents) 0 (Antineoplastic Agents) 0 (Triazenes) |
تواريخ الأحداث: | Date Created: 20210129 Date Completed: 20210917 Latest Revision: 20210917 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC7844262 |
DOI: | 10.1038/s41598-021-81823-2 |
PMID: | 33510223 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-021-81823-2 |