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Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement.

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العنوان: Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement.
المؤلفون: Narayanasamy S; Department of Infectious Diseases, Austin Health, Melbourne, Australia., Nation RL; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., Mahony AA; Department of Infectious Diseases, Austin Health, Melbourne, Australia., Grayson ML; Department of Infectious Diseases, Austin Health, Melbourne, Australia.; Department of Medicine, University of Melbourne, Melbourne, Australia., Kwong JC; Department of Infectious Diseases, Austin Health, Melbourne, Australia.; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne at the Doherty Institute for Infection & Immunity, Melbourne, Australia., Sherry NL; Department of Infectious Diseases, Austin Health, Melbourne, Australia.; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne at the Doherty Institute for Infection & Immunity, Melbourne, Australia., Khumra S; Department of Pharmacy, Austin Health, Melbourne, Australia., Ellis AG; Department of Medicine, University of Melbourne, Melbourne, Australia.; Department of Clinical Pharmacology, Austin Health, Melbourne, Australia., Frauman AG; Department of Medicine, University of Melbourne, Melbourne, Australia.; Department of Clinical Pharmacology, Austin Health, Melbourne, Australia., Holmes NE; Department of Infectious Diseases, Austin Health, Melbourne, Australia.; Department of Medicine, University of Melbourne, Melbourne, Australia.
المصدر: Open forum infectious diseases [Open Forum Infect Dis] 2020 Nov 26; Vol. 8 (1), pp. ofaa572. Date of Electronic Publication: 2020 Nov 26 (Print Publication: 2021).
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Published by Oxford University Press on behalf of the Infectious Diseases Society of America Country of Publication: United States NLM ID: 101637045 Publication Model: eCollection Cited Medium: Print ISSN: 2328-8957 (Print) Linking ISSN: 23288957 NLM ISO Abbreviation: Open Forum Infect Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cary, NC : Published by Oxford University Press on behalf of the Infectious Diseases Society of America, [2014]-
مستخلص: We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity.
(© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
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فهرسة مساهمة: Keywords: XDR gram-negative; colistin; fosfomycin; osteomyelitis; therapeutic drug monitoring
تواريخ الأحداث: Date Created: 20210129 Latest Revision: 20210202
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7817083
DOI: 10.1093/ofid/ofaa572
PMID: 33511225
قاعدة البيانات: MEDLINE
الوصف
تدمد:2328-8957
DOI:10.1093/ofid/ofaa572