دورية أكاديمية
Different Blood Metabolomics Profiles in Infants Consuming a Meat- or Dairy-Based Complementary Diet.
العنوان: | Different Blood Metabolomics Profiles in Infants Consuming a Meat- or Dairy-Based Complementary Diet. |
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المؤلفون: | Tang M; Section of Nutrition, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Weaver NE; Department of Mathematical and Statistical Sciences, University of Colorado Denver, Denver, CO 80204, USA., Berman LM; Section of Nutrition, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Brown LD; Section of Neonatology, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Hendricks AE; Department of Mathematical and Statistical Sciences, University of Colorado Denver, Denver, CO 80204, USA., Krebs NF; Section of Nutrition, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. |
المصدر: | Nutrients [Nutrients] 2021 Jan 27; Vol. 13 (2). Date of Electronic Publication: 2021 Jan 27. |
نوع المنشور: | Journal Article; Randomized Controlled Trial |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI Publishing |
مواضيع طبية MeSH: | Dairy Products* , Diet* , Infant Nutritional Physiological Phenomena* , Meat* , Metabolomics*, Amino Acids, Branched-Chain/blood ; Amino Acids, Essential/blood ; Carnitine/analogs & derivatives ; Carnitine/blood ; Follow-Up Studies ; Humans ; Infant ; Isoleucine/blood ; Leucine/blood ; Phenylalanine/blood ; Valine/blood |
مستخلص: | Background: Research is limited in evaluating the mechanisms responsible for infant growth in response to different protein-rich foods; Methods: Targeted and untargeted metabolomics analysis were conducted on serum samples collected from an infant controlled-feeding trial that participants consumed a meat- vs. dairy-based complementary diet from 5 to 12 months of age, and followed up at 24 months. Results: Isoleucine, valine, phenylalanine increased and threonine decreased over time among all participants; Although none of the individual essential amino acids had a significant impact on changes in growth Z scores from 5 to 12 months, principal component heavily weighted by BCAAs (leucine, isoleucine, valine) and phenylalanine had a positive association with changes in length-for-age Z score from 5 to 12 months. Concentrations of acylcarnitine-C4, acylcarnitine-C5 and acylcarnitine-C5:1 significantly increased over time with the dietary intervention, but none of the acylcarnitines were associated with infant growth Z scores. Quantitative trimethylamine N-oxide increased in the meat group from 5 to 12 months; Conclusions: Our findings suggest that increasing total protein intake by providing protein-rich complementary foods was associated with increased concentrations of certain essential amino acids and short-chain acyl-carnitines. The sources of protein-rich foods (e.g., meat vs. dairy) did not appear to differentially impact serum metabolites, and comprehensive mechanistic investigations are needed to identify other contributors or mediators of the diet-induced infant growth trajectories. |
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معلومات مُعتمدة: | R01 HD079404 United States HD NICHD NIH HHS; P30 DK048520 United States DK NIDDK NIH HHS; NA National Pork Board; NA American Heart Association; NA National Cattlemen's Beef Association; 1K01DK111665-01 United States DK NIDDK NIH HHS; K01 DK111665 United States DK NIDDK NIH HHS; UL1 TR001082 United States NH NIH HHS |
فهرسة مساهمة: | Keywords: growth; infant nutrition; metabolomics; protein-rich foods |
المشرفين على المادة: | 0 (Amino Acids, Branched-Chain) 0 (Amino Acids, Essential) 0 (acylcarnitine) 04Y7590D77 (Isoleucine) 47E5O17Y3R (Phenylalanine) GMW67QNF9C (Leucine) HG18B9YRS7 (Valine) S7UI8SM58A (Carnitine) |
تواريخ الأحداث: | Date Created: 20210130 Date Completed: 20210517 Latest Revision: 20210929 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC7912106 |
DOI: | 10.3390/nu13020388 |
PMID: | 33513734 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2072-6643 |
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DOI: | 10.3390/nu13020388 |