دورية أكاديمية
Spontaneous Emergence of Azithromycin Resistance in Independent Lineages of Salmonella Typhi in Northern India.
| العنوان: | Spontaneous Emergence of Azithromycin Resistance in Independent Lineages of Salmonella Typhi in Northern India. |
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| المؤلفون: | Carey ME; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Jain R; Civil Hospital, Manimajra, Chandigarh, India., Yousuf M; Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Maes M; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Dyson ZA; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, United Kingdom.; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Victoria, Australia.; London School of Hygiene and Tropical Medicine, London, United Kingdom., Thu TNH; The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Nguyen Thi Nguyen T; The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Ho Ngoc Dan T; The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Nhu Pham Nguyen Q; The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Mahindroo J; Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Thanh Pham D; The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom., Sandha KS; Civil Hospital, Manimajra, Chandigarh, India., Baker S; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Taneja N; Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Mar 01; Vol. 72 (5), pp. e120-e127. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | Salmonella typhi*/genetics , Typhoid Fever*/epidemiology, Anti-Bacterial Agents/pharmacology ; Azithromycin/pharmacology ; Bangladesh/epidemiology ; Cross-Sectional Studies ; Drug Resistance, Bacterial ; Genotype ; Humans ; India/epidemiology ; Microbial Sensitivity Tests ; Nepal ; Pakistan ; Phylogeny |
| مستخلص: | Background: The emergence and spread of antimicrobial resistance (AMR) pose a major threat to the effective treatment and control of typhoid fever. The ongoing outbreak of extensively drug-resistant Salmonella Typhi (S. Typhi) in Pakistan has left azithromycin as the only remaining broadly efficacious oral antimicrobial for typhoid in South Asia. Ominously, azithromycin-resistant S. Typhi organisms have been subsequently reported in Bangladesh, Pakistan, and Nepal. Methods: Here, we aimed to understand the molecular basis of AMR in 66 S. Typhi organisms isolated in a cross-sectional study performed in a suburb of Chandigarh in Northern India using whole-genome sequencing and phylogenetic analysis. Results: We identified 7 S. Typhi organisms with the R717Q mutation in the acrB gene that was recently found to confer resistance to azithromycin in Bangladesh. Six out of the seven azithromycin-resistant S. Typhi isolates also exhibited triple mutations in gyrA (S83F and D87N) and parC (S80I) genes and were resistant to ciprofloxacin. These contemporary ciprofloxacin/azithromycin-resistant isolates were phylogenetically distinct from each other and from those reported from Bangladesh, Pakistan, and Nepal. Conclusions: The independent emergence of azithromycin-resistant typhoid in Northern India reflects an emerging broader problem across South Asia and illustrates the urgent need for the introduction of typhoid conjugate vaccines in the region. (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.) |
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| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust; United Kingdom DH_ Department of Health; 215515/Z/19/Z United Kingdom WT_ Wellcome Trust |
| فهرسة مساهمة: | Keywords: Salmonella Typhi; India; antimicrobial resistance; azithromycin resistance; typhoid fever |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 83905-01-5 (Azithromycin) |
| تواريخ الأحداث: | Date Created: 20210130 Date Completed: 20210428 Latest Revision: 20240807 |
| رمز التحديث: | 20240807 |
| مُعرف محوري في PubMed: | PMC7935384 |
| DOI: | 10.1093/cid/ciaa1773 |
| PMID: | 33515460 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1093/cid/ciaa1773 |