دورية أكاديمية
أعرض في EDS

Research Note: Evaluation of acute oral toxicity of povidone-iodine in cockerels using the up-and-down procedure.

التفاصيل البيبلوغرافية
العنوان: Research Note: Evaluation of acute oral toxicity of povidone-iodine in cockerels using the up-and-down procedure.
المؤلفون: Sani D; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University Zaria, Samaru, Zaria, Nigeria; Clinical Pharmacology Specialty, Medicine Faculty, Ahmadu Bello University Study Center, College of Veterinary Surgeons, Samaru, Zaria, Nigeria. Electronic address: mdsani77@gmail.com., Abdu PA; Department of Medicine, Faculty of Veterinary Medicine, Ahmadu Bello University Zaria, Samaru, Zaria, Nigeria., Mamman M; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University Zaria, Samaru, Zaria, Nigeria., Jolayemi KO; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University Zaria, Samaru, Zaria, Nigeria., Yusuf PO; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University Zaria, Samaru, Zaria, Nigeria., Andamin AD; Department of Animal Health Technology, Federal College of Horticulture, Dadin-Kowa, Gombe, Nigeria.
المصدر: Poultry science [Poult Sci] 2021 Feb; Vol. 100 (2), pp. 631-634. Date of Electronic Publication: 2020 Nov 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 0401150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3171 (Electronic) Linking ISSN: 00325791 NLM ISO Abbreviation: Poult Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: 2020- : [Cambridge, UK] : Elsevier
Original Publication: Champaign Il : Poultry Science Association
مواضيع طبية MeSH: Chickens*/blood, Anti-Infective Agents, Local/*toxicity , Birnaviridae Infections/*veterinary , Infectious bursal disease virus/*drug effects , Poultry Diseases/*drug therapy , Povidone-Iodine/*toxicity, Administration, Oral ; Animals ; Anti-Infective Agents, Local/administration & dosage ; Birnaviridae Infections/drug therapy ; Blood Chemical Analysis/veterinary ; Hematologic Tests/veterinary ; Kidney/drug effects ; Lethal Dose 50 ; Liver/drug effects ; Male ; Povidone-Iodine/administration & dosage
مستخلص: Povidone-iodine (Polidine) is a synthetic broad-spectrum antiseptic and being applied topically to treat wounds and prevent their infection. It is however used by poultry farmers, field veterinarians, and other animal health workers with the claim that it is effective for treatment of infectious bursal disease when administered orally. Hence, an acute oral toxicity study was conducted to ascertain its safety profile. Ten cockerel chicks were randomly selected and divided into 2 groups of 5 chicks per group. One group served as the negative control, whereas the other group was administered povidone-iodine at a dose of 2,000 mg/kg of BW orally. The blood sample was collected at the end of the study to determine changes in hematological and biochemical parameters. In addition, vital organs were also harvested and preserved for histopathological examinations. The result showed that the median lethal dose (LD 50 ) of the povidone-iodine is higher than 2,000 mg/kg of BW in cockerels. There were no significant changes in the hematological parameters measured. Biochemical evaluation (renal and liver function test) showed an increase in aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase levels after administration of povidone-iodine. The study indicated that the LD 50 of povidone-iodine is higher than 2,000 mg/kg of BW of cockerels, and there were increases in urinary and liver enzymes at this dose.
(Copyright © 2020. Published by Elsevier Inc.)
References: Lancet. 1976 Feb 7;1(7954):280-2. (PMID: 55590)
Drug Chem Toxicol. 2014 Jul;37(3):268-75. (PMID: 24219135)
Hum Exp Toxicol. 2011 Oct;30(10):1716-9. (PMID: 21300686)
J Ethnopharmacol. 2006 Feb 20;103(3):484-90. (PMID: 16213120)
J Vet Med. 2016;2016:8182160. (PMID: 27597990)
Toxicol Rep. 2017 Oct 31;4:580-585. (PMID: 29152463)
Fundam Appl Toxicol. 1985 Feb;5(1):151-7. (PMID: 3987991)
فهرسة مساهمة: Keywords: cockerel; median lethal dose; povidone-iodine
المشرفين على المادة: 0 (Anti-Infective Agents, Local)
85H0HZU99M (Povidone-Iodine)
تواريخ الأحداث: Date Created: 20210201 Date Completed: 20210423 Latest Revision: 20210423
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7858085
DOI: 10.1016/j.psj.2020.11.002
PMID: 33518116
قاعدة البيانات: MEDLINE
الوصف
تدمد:1525-3171
DOI:10.1016/j.psj.2020.11.002