دورية أكاديمية
Physical Activity Improves Anxiety and Apathy in Early Parkinson's Disease: A Longitudinal Follow-Up Study.
| العنوان: | Physical Activity Improves Anxiety and Apathy in Early Parkinson's Disease: A Longitudinal Follow-Up Study. |
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| المؤلفون: | Ng SY; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Parkinson's Disease and Movement Disorders Centre, NPF International Center of Excellence, National Neuroscience Institute, Singapore, Singapore., Chia NS; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Parkinson's Disease and Movement Disorders Centre, NPF International Center of Excellence, National Neuroscience Institute, Singapore, Singapore., Abbas MM; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Parkinson's Disease and Movement Disorders Centre, NPF International Center of Excellence, National Neuroscience Institute, Singapore, Singapore., Saffari ES; Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore., Choi X; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Parkinson's Disease and Movement Disorders Centre, NPF International Center of Excellence, National Neuroscience Institute, Singapore, Singapore., Heng DL; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Parkinson's Disease and Movement Disorders Centre, NPF International Center of Excellence, National Neuroscience Institute, Singapore, Singapore., Xu Z; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Parkinson's Disease and Movement Disorders Centre, NPF International Center of Excellence, National Neuroscience Institute, Singapore, Singapore.; Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore., Tay KY; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Parkinson's Disease and Movement Disorders Centre, NPF International Center of Excellence, National Neuroscience Institute, Singapore, Singapore.; Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore., Au WL; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Parkinson's Disease and Movement Disorders Centre, NPF International Center of Excellence, National Neuroscience Institute, Singapore, Singapore.; Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore., Tan EK; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Parkinson's Disease and Movement Disorders Centre, NPF International Center of Excellence, National Neuroscience Institute, Singapore, Singapore.; Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore., Tan LC; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Parkinson's Disease and Movement Disorders Centre, NPF International Center of Excellence, National Neuroscience Institute, Singapore, Singapore.; Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore. |
| المصدر: | Frontiers in neurology [Front Neurol] 2021 Jan 15; Vol. 11, pp. 625897. Date of Electronic Publication: 2021 Jan 15 (Print Publication: 2020). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2295 (Print) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation, 2010]- |
| مستخلص: | Objective: In a prospective study, we investigated the association between physical activity and various motor, non-motor outcomes, and quality of life in early Parkinson's disease (PD) participants in the PD Longitudinal Singapore Study. Background: Prospective studies that examined the association between physical activity and motor and non-motor domains in early PD are lacking. Methods: 121 PD participants were followed-up prospectively to evaluate the association of physical activity with various symptom domains. The Physical Activity Scale for the Elderly (PASE) was used to measure physical activity annually. PD-related symptoms were categorized by motor, non-motor, and quality of life measures. Multivariate regression with gain score analysis was performed to understand the association of baseline PASE scores with the change of each variable at 1-year follow-up. Results: Higher baseline PASE scores (greater activity) were associated with a younger age, lower MDS-UPDRS motor scores, a smaller levodopa equivalent daily dose, better attention and memory scores, and better QoL. Activity scores in early PD declined on follow-up. Multivariate analysis revealed higher baseline physical activity to be associated with decreased anxiety and apathy scores at 1-year follow-up, after adjusting for demographic variables and medications. Conclusion: We demonstrated that higher baseline physical activity was associated with improved anxiety and apathy symptoms in early PD over a 1-year period. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Ng, Chia, Abbas, Saffari, Choi, Heng, Xu, Tay, Au, Tan and Tan.) |
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| فهرسة مساهمة: | Keywords: anxiety; apathy; early Parkinson's disease; non-motor; physical activity |
| تواريخ الأحداث: | Date Created: 20210201 Latest Revision: 20210202 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7843441 |
| DOI: | 10.3389/fneur.2020.625897 |
| PMID: | 33519706 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-2295 |
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| DOI: | 10.3389/fneur.2020.625897 |