دورية أكاديمية
أعرض في EDS

Moringa oleifera leaf fractions attenuated Naje haje venom-induced cellular dysfunctions via modulation of Nrf2 and inflammatory signalling pathways in rats.

التفاصيل البيبلوغرافية
العنوان: Moringa oleifera leaf fractions attenuated Naje haje venom-induced cellular dysfunctions via modulation of Nrf2 and inflammatory signalling pathways in rats.
المؤلفون: Adeyi AO; Animal Physiology Unit, Department of Zoology, University of Ibadan, Nigeria., Ajisebiola BS; Department of Zoology, Osun State University, Osogbo, Nigeria., Adeyi OE; Department of Biochemistry, Federal University of Agriculture, Abeokuta, Nigeria., Adekunle O; Department of Pure and Applied Zoology, Federal University of Agriculture, Abeokuta, Nigeria., Akande OB; Department of Pure and Applied Zoology, Federal University of Agriculture, Abeokuta, Nigeria., James AS; Department of Biochemistry, Federal University of Agriculture, Abeokuta, Nigeria., Ajayi BO; Department of Biochemistry, Bowen University, Iwo, Nigeria., Yusuf PO; Department of Veterinary Pharmacology and Toxicology, Ahmadu Bello University, Zaria, Nigeria., Idowu BA; Department of Pure and Applied Zoology, Federal University of Agriculture, Abeokuta, Nigeria.
المصدر: Biochemistry and biophysics reports [Biochem Biophys Rep] 2021 Jan 20; Vol. 25, pp. 100890. Date of Electronic Publication: 2021 Jan 20 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101660999 Publication Model: eCollection Cited Medium: Internet ISSN: 2405-5808 (Electronic) Linking ISSN: 24055808 NLM ISO Abbreviation: Biochem Biophys Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier B.V., [2015]-
مستخلص: Naja haje envenoming could activate multiple pathways linked to haematotoxic, neurological, and antioxidant systems dysfunctions. Moringa oleifera has been used in the management of different snake venom-induced toxicities, but there is no scientific information on its antivenom effects against Naja haje . This study thus, investigated the antivenom activities of different extract partitions of M. oleifera leaves against N. haje envenoming . Forty five male rats were divided into nine groups (n = 5). Groups 2 to 9 were envenomed with 0.025 mg/kg (LD 50 ) of N . haje venom while group 1 was given saline. Group 2 was left untreated, while group 3 was treated with polyvalent antivenom, groups 4, 6 and 8 were treated with 300 mg/kg -1 of N-hexane, ethylacetate and ethanol partitions of M. oleifera, respectively. Groups 5, 7 and 9 were also treated with 600 mgkg -1 of the partitions , respectively. Ethanol extract and ethyl acetate partition of M. oleifera significantly improved haematological indices following acute anaemia induced by the venom. Likewise, haemorrhagic, haemolytic and anti-coagulant activities of N. haje venom were best inhibited by ethanol partition. Envenoming significantly down-regulated Nuclear factor erythroid 2-related factor 2 (Nrf2) with the consequent elevation of antioxidant enzymes activities in the serum and brain. Treatment with extract partitions however, elevated Nrf2 levels while normalising antioxidant enzyme activities. Furthermore, there were reduction in levels of pro-inflammatory cytokines (TNF-α and interleukin-1β) in tissues of treated envenomed rats. This study concludes that ethanol partition of M. oleifera was most effective against N. haje venom and could be considered as a potential source for antivenom metabolites.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2021 The Authors.)
References: Toxicon. 2009 Dec 1;54(7):988-97. (PMID: 19774698)
Toxicol Rep. 2018 Mar 01;5:318-323. (PMID: 29854600)
Med Toxicol Adverse Drug Exp. 1989 Jan-Feb;4(1):17-31. (PMID: 2468987)
Biomed Environ Sci. 2012 Dec;25(6):630-8. (PMID: 23228832)
Toxicon. 1998 Apr;36(4):657-64. (PMID: 9643479)
Phytomedicine. 2007 Sep;14(9):637-43. (PMID: 17293096)
Comp Biochem Physiol A Mol Integr Physiol. 1998 Feb;119(2):621-7. (PMID: 11249011)
Biochem Biophys Res Commun. 1999 Dec 20;266(2):488-91. (PMID: 10600529)
Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G729-38. (PMID: 17640978)
Free Radic Biol Med. 2004 May 15;36(10):1199-207. (PMID: 15110384)
Biochem Pharmacol. 1997 May 9;53(9):1315-22. (PMID: 9214692)
Toxicon. 2000 Sep;38(9):1253-66. (PMID: 10736479)
J Mol Cell Cardiol. 2013 Apr;57:82-95. (PMID: 23353773)
PLoS One. 2015 Apr 10;10(4):e0122185. (PMID: 25860015)
J Venom Anim Toxins Incl Trop Dis. 2014 Sep 15;20(1):42. (PMID: 25258623)
J Biol Chem. 1972 May 25;247(10):3170-5. (PMID: 4623845)
Pharmacol Res. 2010 Mar;61(3):219-25. (PMID: 19914380)
Toxicol Rep. 2014 Aug 29;1:667-673. (PMID: 28962280)
Toxicon. 1995 Nov;33(11):1405-24. (PMID: 8744981)
Toxicon. 2003 Apr;41(5):541-57. (PMID: 12676433)
Toxicon. 1994 May;32(5):595-603. (PMID: 8079371)
Food Chem Toxicol. 2014 Jul;69:175-81. (PMID: 24751971)
Horm Metab Res. 2003 Mar;35(3):147-52. (PMID: 12734774)
Lipids Health Dis. 2011 Dec 09;10:232. (PMID: 22151830)
Ann Allergy Asthma Immunol. 2000 Jul;85(1):9-18; quiz 18, 21. (PMID: 10923599)
Clin Chim Acta. 1978 Nov 15;90(1):37-43. (PMID: 719890)
Curr Med Chem. 2005;12(22):2625-41. (PMID: 16248818)
Bull World Health Organ. 1983;61(6):949-56. (PMID: 6609011)
Bioinformation. 2012;8(1):48-57. (PMID: 22359435)
Toxicon. 1991;29(11):1279-303. (PMID: 1814005)
Eur J Immunol. 2003 Dec;33(12):3458-63. (PMID: 14635056)
Biomed Res Int. 2014;2014:647131. (PMID: 25162019)
Am J Emerg Med. 1999 Oct;17(6):548-51. (PMID: 10530532)
Cell Biochem Funct. 2013 Jan;31(1):41-50. (PMID: 22893269)
Oxid Med Cell Longev. 2015;2015:570650. (PMID: 26101558)
Anal Biochem. 1972 Jun;47(2):389-94. (PMID: 4556490)
Toxicon. 2003 Dec 15;42(8):947-62. (PMID: 15019493)
فهرسة مساهمة: Keywords: Albino rat; Antivenom; Egyptian cobra; Inflammation; Moringa oleifera; Nrf2; Oxidative stress; Snakebite
تواريخ الأحداث: Date Created: 20210201 Latest Revision: 20231110
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7820385
DOI: 10.1016/j.bbrep.2020.100890
PMID: 33521334
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-5808
DOI:10.1016/j.bbrep.2020.100890