دورية أكاديمية
Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children.
| العنوان: | Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children. |
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| المؤلفون: | da Silva Chagas L; Laboratory of Neural Plasticity, Neurobiology Department, Biology Institute, Federal Fluminense University, Niteroi, Brazil., Sandre PC; Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., de Velasco PC; Department of Applied Nutrition, Institute of Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil., Marcondes H; Laboratory of Neural Plasticity, Neurobiology Department, Biology Institute, Federal Fluminense University, Niteroi, Brazil., Ribeiro E Ribeiro NCA; Laboratory of Neural Plasticity, Neurobiology Department, Biology Institute, Federal Fluminense University, Niteroi, Brazil., Barreto AL; Laboratory of Neural Plasticity, Neurobiology Department, Biology Institute, Federal Fluminense University, Niteroi, Brazil., Alves Mauro LB; Laboratory of Neural Plasticity, Neurobiology Department, Biology Institute, Federal Fluminense University, Niteroi, Brazil., Ferreira JH; Laboratory of Neural Plasticity, Neurobiology Department, Biology Institute, Federal Fluminense University, Niteroi, Brazil., Serfaty CA; Laboratory of Neural Plasticity, Neurobiology Department, Biology Institute, Federal Fluminense University, Niteroi, Brazil, cserfaty@id.uff.br.; National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, cserfaty@id.uff.br. |
| المصدر: | Neuroimmunomodulation [Neuroimmunomodulation] 2021; Vol. 28 (1), pp. 22-28. Date of Electronic Publication: 2021 Feb 02. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: S. Karger Medical and Scientific Publishers Country of Publication: Switzerland NLM ID: 9422763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0216 (Electronic) Linking ISSN: 10217401 NLM ISO Abbreviation: Neuroimmunomodulation Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : S. Karger Medical and Scientific Publishers, [1994- |
| مواضيع طبية MeSH: | Brain/*growth & development , COVID-19/*immunology , Inflammation/*immunology , Microglia/*immunology , Neurodevelopmental Disorders/*immunology, Brain/immunology ; Brain/physiopathology ; COVID-19/physiopathology ; Diet ; Dietary Fats, Unsaturated ; Fatty Acids, Unsaturated ; Fetal Alcohol Spectrum Disorders/immunology ; Fetal Alcohol Spectrum Disorders/physiopathology ; Humans ; Inflammation/physiopathology ; Neurodevelopmental Disorders/physiopathology ; Neuronal Plasticity ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Systemic Inflammatory Response Syndrome |
| مستخلص: | COVID-19, a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) betacoronavirus, affects children in a different way than it does in adults, with milder symptoms. However, several cases of neurological symptoms with neuroinflammatory syndromes, such as the multisystem inflammatory syndrome (MIS-C), following mild cases, have been reported. As with other viral infections, such as rubella, influenza, and cytomegalovirus, SARS-CoV-2 induces a surge of proinflammatory cytokines that affect microglial function, which can be harmful to brain development. Along with the viral induction of neuroinflammation, other noninfectious conditions may interact to produce additional inflammation, such as the nutritional imbalance of fatty acids and polyunsaturated fatty acids and alcohol consumption during pregnancy. Additionally, transient thyrotoxicosis induced by SARS-CoV-2 with secondary autoimmune hypothyroidism has been reported, which could go undetected during pregnancy. Together, those factors may pose additional risk factors for SARS-CoV-2 infection impacting mechanisms of neural development such as synaptic pruning and neural circuitry formation. The present review discusses those conditions in the perspective of the understanding of risk factors that should be considered and the possible emergence of neurodevelopmental disorders in COVID-19-infected children. (© 2021 S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Brain development; COVID-19; Children; Environmental risk factors; Neuroinflammation; Nutrition; Synapse formation |
| المشرفين على المادة: | 0 (Dietary Fats, Unsaturated) 0 (Fatty Acids, Unsaturated) |
| SCR Disease Name: | pediatric multisystem inflammatory disease, COVID-19 related |
| تواريخ الأحداث: | Date Created: 20210202 Date Completed: 20210528 Latest Revision: 20210528 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC7900470 |
| DOI: | 10.1159/000512815 |
| PMID: | 33530091 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1423-0216 |
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| DOI: | 10.1159/000512815 |