دورية أكاديمية
أعرض في EDS

Variability in Hemoglobin Levels and the Factors Associated with Mortality in Hemodialysis Patients: A 78-Month Follow-Up Study.

التفاصيل البيبلوغرافية
العنوان: Variability in Hemoglobin Levels and the Factors Associated with Mortality in Hemodialysis Patients: A 78-Month Follow-Up Study.
المؤلفون: Salgado Filho N; Renal Division, Federal University of Maranhão, São Luís 65020-070, Brazil., Lages JS; Renal Division, Federal University of Maranhão, São Luís 65020-070, Brazil., Brito DJA; Renal Division, Federal University of Maranhão, São Luís 65020-070, Brazil., Santos EJF; Renal Division, Federal University of Maranhão, São Luís 65020-070, Brazil., Dos Santos AM; Renal Division, Federal University of Maranhão, São Luís 65020-070, Brazil., de Souza FL; Renal Division, Federal University of Maranhão, São Luís 65020-070, Brazil., Mendes VGG; Renal Division, Federal University of Maranhão, São Luís 65020-070, Brazil., Silva GADS; Renal Division, Federal University of Maranhão, São Luís 65020-070, Brazil., Carneiro ECRL; Renal Division, Federal University of Maranhão, São Luís 65020-070, Brazil., Muniz MPR; Renal Division, Federal University of Maranhão, São Luís 65020-070, Brazil., Silva GEB; Renal Division, Federal University of Maranhão, São Luís 65020-070, Brazil.; Pathology Division, University of São Paulo (USP), Ribeirão Preto 14049-900, Brazil., Sesso RCC; Discipline of Nephrology, Paulista School of Medicina, Federal University of São Paulo, São Paulo 04023-062, Brazil.
المصدر: International journal of environmental research and public health [Int J Environ Res Public Health] 2021 Jan 26; Vol. 18 (3). Date of Electronic Publication: 2021 Jan 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238455 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-4601 (Electronic) Linking ISSN: 16604601 NLM ISO Abbreviation: Int J Environ Res Public Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI, c2004-
مواضيع طبية MeSH: Hematinics* , Kidney Failure, Chronic*/therapy, Adult ; Female ; Follow-Up Studies ; Hemoglobins/analysis ; Humans ; Middle Aged ; Prospective Studies ; Renal Dialysis
مستخلص: Some studies have described that when the hemoglobin levels of chronic kidney disease (CKD) patients change, especially in those taking erythropoiesis-stimulating agents (ESA), they are associated with unfavorable outcomes such as increased morbidity and mortality, mainly due to cardiovascular events. This prospective cohort study included patients with end-stage renal disease currently undergoing hemodialysis. The initial 6-month clinical evaluation provided data of the variability in hemoglobin, associated blood parameters, and the use of erythropoietin. Subsequently, the patients were followed up for 78 months to evaluate mortality-associated factors. In total, 133 patients completed the 6-month follow-up with a mean age of 47.1 (±13.2) years. The majority were women (51.9%). Six-month hemoglobin levels were as follows: always low (18.0%), intermediate/target (1.5%), always high (0.8%), low-amplitude fluctuation/Hb low ( n = 37; 27.8%), low-amplitude fluctuation/Hb high (13.53%), and high-amplitude fluctuation (38.6%), among end-stage renal disease patients. At the end of 78 months, 50 (37.6%) patients died; 70% of deaths were attributed to cardiovascular etiologies. A high variability was observed in hemoglobin levels, which was not associated with mortality. Among all the variables evaluated, age, erythropoietin dose, and transferrin saturation were associated with a higher mortality. Thus, this study suggests that greater attention to erythropoietin doses and transferrin saturation levels may improve the survival of dialysis patients.
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فهرسة مساهمة: Keywords: erythropoiesis-stimulating agents; hemodialysis; hemoglobin; mortality
المشرفين على المادة: 0 (Hematinics)
0 (Hemoglobins)
تواريخ الأحداث: Date Created: 20210203 Date Completed: 20210326 Latest Revision: 20210326
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7908351
DOI: 10.3390/ijerph18031078
PMID: 33530448
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-4601
DOI:10.3390/ijerph18031078