دورية أكاديمية
أعرض في EDS

Prediction of SARS-CoV Interaction with Host Proteins during Lung Aging Reveals a Potential Role for TRIB3 in COVID-19.

التفاصيل البيبلوغرافية
العنوان: Prediction of SARS-CoV Interaction with Host Proteins during Lung Aging Reveals a Potential Role for TRIB3 in COVID-19.
المؤلفون: de Moraes D; 1Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil., Paiva BVB; 1Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.; 2Faculty of Medicine, São Paulo State University, UNESP, Botucatu, São Paulo, Brazil., Cury SS; 1Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil., Ludwig RG; 4Department of Biochemistry and Tissue Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, SP, Brazil., Junior JPA; 3Department of Chemical and Biological Sciences, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil., Mori MADS; 4Department of Biochemistry and Tissue Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, SP, Brazil., Carvalho RF; 1Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
المصدر: Aging and disease [Aging Dis] 2021 Feb 01; Vol. 12 (1), pp. 42-49. Date of Electronic Publication: 2021 Feb 01 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: JKL International Country of Publication: United States NLM ID: 101540533 Publication Model: eCollection Cited Medium: Print ISSN: 2152-5250 (Print) Linking ISSN: 21525250 NLM ISO Abbreviation: Aging Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: California : JKL International
مستخلص: COVID-19 is prevalent in the elderly. Old individuals are more likely to develop pneumonia and respiratory failure due to alveolar damage, suggesting that lung senescence may increase the susceptibility to SARS-CoV-2 infection and replication. Considering that human coronavirus (HCoVs; SARS-CoV-2 and SARS-CoV) require host cellular factors for infection and replication, we analyzed Genotype-Tissue Expression (GTEx) data to test whether lung aging is associated with transcriptional changes in human protein-coding genes that potentially interact with these viruses. We found decreased expression of the gene tribbles homolog 3 ( TRIB3 ) during aging in male individuals, and its protein was predicted to interact with HCoVs nucleocapsid protein and RNA-dependent RNA polymerase. Using publicly available lung single-cell data, we found TRIB3 expressed mainly in alveolar epithelial cells that express SARS-CoV-2 receptor ACE2. Functional enrichment analysis of age-related genes, in common with SARS-CoV-induced perturbations, revealed genes associated with the mitotic cell cycle and surfactant metabolism. Given that TRIB3 was previously reported to decrease virus infection and replication, the decreased expression of TRIB3 in aged lungs may help explain why older male patients are related to more severe cases of the COVID-19. Thus, drugs that stimulate TRIB3 expression should be evaluated as a potential therapy for the disease.
(copyright: © 2021 Moraes et al.)
References: Nature. 2020 Mar;579(7798):270-273. (PMID: 32015507)
Gynecol Oncol. 2019 May;153(2):425-435. (PMID: 30853360)
N Engl J Med. 2020 Mar 26;382(13):1199-1207. (PMID: 31995857)
Cell. 2013 Jun 6;153(6):1194-217. (PMID: 23746838)
Toxicol Sci. 2011 Aug;122(2):437-47. (PMID: 21613230)
Eur Respir J. 2020 Aug 13;56(2):. (PMID: 32817205)
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613. (PMID: 30476243)
Cell Syst. 2018 Nov 28;7(5):556-561.e3. (PMID: 30447998)
Cell. 2019 Sep 5;178(6):1526-1541.e16. (PMID: 31474372)
J Clin Invest. 2004 Nov;114(9):1299-307. (PMID: 15520862)
Lancet. 2020 Feb 15;395(10223):507-513. (PMID: 32007143)
Nat Rev Mol Cell Biol. 2014 Jul;15(7):482-96. (PMID: 24954210)
Cell Death Discov. 2018 Aug 20;4:26. (PMID: 30155276)
BMC Bioinformatics. 2014 Aug 29;15:293. (PMID: 25176396)
Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72. (PMID: 19304906)
mSystems. 2019 Apr 9;4(2):. (PMID: 30984872)
Nat Cell Biol. 2006 Nov;8(11):1291-7. (PMID: 17028578)
Nucleic Acids Res. 2015 Apr 20;43(7):e47. (PMID: 25605792)
Elife. 2018 Feb 16;7:. (PMID: 29451494)
J Pathol. 2015 Jan;235(2):185-95. (PMID: 25270030)
CMAJ. 2020 May 19;192(20):E551. (PMID: 32332038)
J Virol. 2020 Mar 17;94(7):. (PMID: 31996437)
Genome Biol. 2019 Dec 31;21(1):1. (PMID: 31892341)
Genome Biol. 2010;11(3):R25. (PMID: 20196867)
Cell Discov. 2020 Mar 16;6:14. (PMID: 32194980)
Nat Microbiol. 2020 Apr;5(4):562-569. (PMID: 32094589)
Nat Genet. 2013 Jun;45(6):580-5. (PMID: 23715323)
J Cell Biol. 2018 Jan 2;217(1):65-77. (PMID: 29114066)
Lancet Infect Dis. 2020 May;20(5):533-534. (PMID: 32087114)
Respir Res. 2001;2(6):353-64. (PMID: 11737935)
J Virol. 2016 Jul 27;90(16):7231-7247. (PMID: 27252525)
Lancet. 2020 Feb 15;395(10223):497-506. (PMID: 31986264)
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7. (PMID: 27141961)
Aging Cell. 2020 Mar;19(3):e13121. (PMID: 32077223)
J Med Virol. 2020 Apr;92(4):441-447. (PMID: 31994742)
Allergy. 2020 Jul;75(7):1730-1741. (PMID: 32077115)
Bioinformatics. 2014 May 1;30(9):1331-2. (PMID: 24443380)
Science. 2015 May 8;348(6235):648-60. (PMID: 25954001)
Cell. 2020 Apr 16;181(2):271-280.e8. (PMID: 32142651)
Radiology. 2020 Jun;295(3):715-721. (PMID: 32053470)
Am J Respir Crit Care Med. 2019 Jun 15;199(12):1517-1536. (PMID: 30554520)
Nature. 2020 Mar;579(7798):265-269. (PMID: 32015508)
فهرسة مساهمة: Keywords: COVID-19; SARS-CoV-2; lung aging; tribbles homolog 3; α-hydroxylinoleic acid
تواريخ الأحداث: Date Created: 20210203 Latest Revision: 20230919
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7801268
DOI: 10.14336/AD.2020.1112
PMID: 33532126
قاعدة البيانات: MEDLINE
الوصف
تدمد:2152-5250
DOI:10.14336/AD.2020.1112