دورية أكاديمية
أعرض في EDS

Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis.

التفاصيل البيبلوغرافية
العنوان: Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis.
المؤلفون: Bouchareb R; Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Guauque-Olarte S; GIOD Group, Faculty of Dentistry, Universidad Cooperativa de Colombia, Pasto, Colombia., Snider J; Biological Mass Spectrometry Shared Resource, Stony Brook University Cancer Center, New York, New York, USA., Zaminski D; Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Anyanwu A; Department of Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Stelzer P; Department of Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Lebeche D; Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Diabetes, Obesity and Metabolism Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
المصدر: JACC. Basic to translational science [JACC Basic Transl Sci] 2021 Jan 13; Vol. 6 (1), pp. 25-39. Date of Electronic Publication: 2021 Jan 13 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier on behalf of the American College of Cardiology Foundation, [2016]-
مستخلص: This study analyzed the expression of extracellular matrix (ECM) proteins during aortic valve calcification with mass spectrometry, and further validated in an independent human cohort using RNAseq data. The study reveals that valve calcification is associated with significant disruption in ECM and metabolic pathways, and highlights a strong connection between metabolic markers and ECM remodeling. It also identifies FNDC1 and MXRA5 as novel ECM biomarkers in calcified valves, electing them as potential targets in the development and progression of aortic stenosis.
Competing Interests: Dr. Bouchareb was supported in part by a National Institutes of Health (NIH) grant T32 HL7824-19; Dr. Lebeche was supported by National Institutes of Health grant R01HL137220. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
(© 2021 The Authors.)
التعليقات: Comment in: JACC Basic Transl Sci. 2021 Jan 25;6(1):40-41. (PMID: 33533758)
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معلومات مُعتمدة: T32 HL007824 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: AS, aortic stenosis; EC, endothelial cell; ECM; ECM, extracellular matrix; FN, fibronectin; FNDC1, fibronectin type III domain containing 1; KEGG, Kyoto Encyclopedia of Genes and Genomes; LDL, low-density lipoprotein; MXRA5, matrix-remodeling-associated protein 5; MetS, metabolic syndrome; PBS, phosphate-buffered saline; RNA-Seq; RNAseq, RNA sequencing; TAVc, calcified tricuspid aortic valve; TAVn, noncalcified tricuspid aortic valve; VAHC, calcified human aortic valve; VAHN, normal human aortic valve; aortic stenosis; calcified aortic valves; hVIC, human valve interstitial cell; metabolism; proteomics
تواريخ الأحداث: Date Created: 20210203 Latest Revision: 20220917
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7838057
DOI: 10.1016/j.jacbts.2020.11.008
PMID: 33532664
قاعدة البيانات: MEDLINE
الوصف
تدمد:2452-302X
DOI:10.1016/j.jacbts.2020.11.008