دورية أكاديمية
أعرض في EDS

Immunopathological Roles of Neutrophils in Virus Infection and COVID-19.

التفاصيل البيبلوغرافية
العنوان: Immunopathological Roles of Neutrophils in Virus Infection and COVID-19.
المؤلفون: Cui SN; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Anesthesiology, Peking University Cancer Hospital and Institute, Beijing, China.; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio., Tan HY; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Anesthesiology, Peking University Cancer Hospital and Institute, Beijing, China., Fan GC; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio.
المصدر: Shock (Augusta, Ga.) [Shock] 2021 Sep 01; Vol. 56 (3), pp. 345-351.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9421564 Publication Model: Print Cited Medium: Internet ISSN: 1540-0514 (Electronic) Linking ISSN: 10732322 NLM ISO Abbreviation: Shock Subsets: MEDLINE
أسماء مطبوعة: Publication: 2002- : Philadelphia : Lippincott Williams & Wilkins
Original Publication: Augusta, GA : BioMedical Press, [1994-
مواضيع طبية MeSH: SARS-CoV-2*, COVID-19/*immunology , COVID-19/*virology , Neutrophils/*virology, Animals ; Cytokine Release Syndrome ; Cytokines/immunology ; Humans ; Immune System ; Immunity, Innate ; Inflammation ; Intercellular Adhesion Molecule-1/immunology ; Lymphocytes/immunology ; Mice ; Neutrophils/metabolism ; Pathogen-Associated Molecular Pattern Molecules/immunology ; Thrombosis
مستخلص: Abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been spread around the world and is currently affecting global public health. Clinical evidence indicates that the elevated number of peripheral neutrophils and higher ratio of neutrophils-to-lymphocytes are correlated with severe outcomes in COVID-19 patients, suggesting the possible immunopathological role of neutrophils during SARS-CoV-2 infection. As an abundant innate immune cell type, neutrophils are well known for their contributions to antimicrobial defense. However, their dysfunction is also associated with different inflammatory signatures during the pathogenesis of infection. Herein, in this mini-review, we summarize the recent progress on the potential role of neutrophils during COVID-19-associated inflammatory responses. In particular, we highlight the interactions between neutrophils and viruses as well as the relationship of neutrophils with cytokine storm and thrombosis in COVID-19 patients. Lastly, we discuss the importance of neutrophils as potential therapeutic targets for COVID-19.
Competing Interests: The authors report no conflicts of interest.
(Copyright © 2021 by the Shock Society.)
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Available at: https://www.botanical.jp/library_view.php?library_num=679 . Accessed May 22, 2020.
المشرفين على المادة: 0 (Cytokines)
0 (Pathogen-Associated Molecular Pattern Molecules)
126547-89-5 (Intercellular Adhesion Molecule-1)
تواريخ الأحداث: Date Created: 20210203 Date Completed: 20210906 Latest Revision: 20230824
رمز التحديث: 20230825
مُعرف محوري في PubMed: PMC8354486
DOI: 10.1097/SHK.0000000000001740
PMID: 33534399
قاعدة البيانات: MEDLINE
الوصف
تدمد:1540-0514
DOI:10.1097/SHK.0000000000001740