دورية أكاديمية
No Evidence of rVSV-Ebola Virus Vaccine Replication or Dissemination in the Sand Fly Phlebotomus papatasi.
| العنوان: | No Evidence of rVSV-Ebola Virus Vaccine Replication or Dissemination in the Sand Fly Phlebotomus papatasi. |
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| المؤلفون: | Haddow AD; 1United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, Maryland., Rowland TE; 2Walter Reed Army Institute of Research, Silver Spring, Maryland., Norris SL; 1United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, Maryland., Sprague TR; 1United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, Maryland., Lopez JO; 2Walter Reed Army Institute of Research, Silver Spring, Maryland., Carder MC; 2Walter Reed Army Institute of Research, Silver Spring, Maryland., Linton YM; 3Walter Reed Biosystematics Unit, Smithsonian Museum Support Center, Suitland, Maryland.; 4Department of Entomology, Smithsonian Institution National Museum of Natural History, Washington, District of Columbia., Pitt MLM; 1United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, Maryland. |
| المصدر: | The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2021 Feb 01; Vol. 104 (3), pp. 1093-1095. Date of Electronic Publication: 2021 Feb 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Northbrook, IL : American Society of Tropical Medicine and Hygiene Original Publication: Baltimore. |
| مواضيع طبية MeSH: | Disease Transmission, Infectious*, Antibodies, Viral/*blood , Ebola Vaccines/*immunology , Ebolavirus/*drug effects , Hemorrhagic Fever, Ebola/*prevention & control , Hemorrhagic Fever, Ebola/*transmission , Phlebotomus/*virology, Animals ; Humans |
| مستخلص: | Following vaccination with the live attenuated, recombinant vesicular stomatitis virus Indiana serotype Ebola virus (rVSV-EBOV) vaccine, persons may exhibit a transient vaccine-associated viremia. To investigate the potential for Old World sand flies to transmit this vaccine following feeding on a viremic person, we fed laboratory-reared Phlebotomus papatasi an artificial blood meal containing 7.2 log10 plaque-forming units of rVSV-EBOV. Replication or dissemination was not detected in the body or legs of any P. papatasi collected at seven (n = 75) or 15 (n = 75) days post-feed. These results indicate a low potential for rVSV-EBOV to replicate and disseminate in P. papatasi, a species whose geographic distribution ranges from Morocco to southwest Asia and as far north as southern Europe. |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Ebola Vaccines) |
| تواريخ الأحداث: | Date Created: 20210203 Date Completed: 20220214 Latest Revision: 20220302 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7941803 |
| DOI: | 10.4269/ajtmh.20-0951 |
| PMID: | 33534737 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1476-1645 |
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| DOI: | 10.4269/ajtmh.20-0951 |