دورية أكاديمية
أعرض في EDS

High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging.

التفاصيل البيبلوغرافية
العنوان: High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging.
المؤلفون: Chen J; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.; Department of Prosthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China., Sivan U; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Tan SL; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Lippo L; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., De Angelis J; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Labella R; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Singh A; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.; Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, Heidelberg D-69120, Germany., Chatzis A; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Cheuk S; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden., Medhghalchi M; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Gil J; Institute of Clinical Sciences, Imperial College London, London W12 0NN, UK.; MRC London Institute of Medical Sciences, Imperial College London, London W12 0NN, UK., Hollander G; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Marsden BD; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.; Structural Genomics Consortium, NDM, University of Oxford, Oxford OX3 7DQ, UK., Williams R; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Ramasamy SK; Institute of Clinical Sciences, Imperial College London, London W12 0NN, UK.; MRC London Institute of Medical Sciences, Imperial College London, London W12 0NN, UK., Kusumbe AP; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK. anjali.kusumbe@kennedy.ox.ac.uk.
المصدر: Science advances [Sci Adv] 2021 Feb 03; Vol. 7 (6). Date of Electronic Publication: 2021 Feb 03 (Print Publication: 2021).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: PubMed not MEDLINE; MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Association for the Advancement of Science, [2015]-
مستخلص: Blood vessels provide supportive microenvironments for maintaining tissue functions. Age-associated vascular changes and their relation to tissue aging and pathology are poorly understood. Here, we perform 3D imaging of young and aging vascular beds. Multiple organs in mice and humans demonstrate an age-dependent decline in vessel density and pericyte numbers, while highly remodeling tissues such as skin preserve the vasculature. Vascular attrition precedes the appearance of cellular hallmarks of aging such as senescence. Endothelial VEGFR2 loss-of-function mice demonstrate that vascular perturbations are sufficient to stimulate cellular changes coupled with aging. Age-associated tissue-specific molecular changes in the endothelium drive vascular loss and dictate pericyte to fibroblast differentiation. Lineage tracing of perivascular cells with inducible PDGFRβ and NG2 Cre mouse lines demonstrated that increased pericyte to fibroblast differentiation distinguishes injury-induced organ fibrosis and zymosan-induced arthritis. To spur further discoveries, we provide a freely available resource with 3D vascular and tissue maps.
(Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).)
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معلومات مُعتمدة: MC_UP_1605/1 United Kingdom MRC_ Medical Research Council; MR/P02209X/1 United Kingdom MRC_ Medical Research Council; 202300/Z/16/Z United Kingdom WT_ Wellcome Trust; MC_U120085810 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust; 28647 United Kingdom CRUK_ Cancer Research UK
تواريخ الأحداث: Date Created: 20210204 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC7857692
DOI: 10.1126/sciadv.abd7819
PMID: 33536212
قاعدة البيانات: MEDLINE
الوصف
تدمد:2375-2548
DOI:10.1126/sciadv.abd7819