دورية أكاديمية
High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging.
العنوان: | High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging. |
---|---|
المؤلفون: | Chen J; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.; Department of Prosthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China., Sivan U; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Tan SL; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Lippo L; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., De Angelis J; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Labella R; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Singh A; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.; Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, Heidelberg D-69120, Germany., Chatzis A; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Cheuk S; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden., Medhghalchi M; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Gil J; Institute of Clinical Sciences, Imperial College London, London W12 0NN, UK.; MRC London Institute of Medical Sciences, Imperial College London, London W12 0NN, UK., Hollander G; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Marsden BD; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.; Structural Genomics Consortium, NDM, University of Oxford, Oxford OX3 7DQ, UK., Williams R; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Ramasamy SK; Institute of Clinical Sciences, Imperial College London, London W12 0NN, UK.; MRC London Institute of Medical Sciences, Imperial College London, London W12 0NN, UK., Kusumbe AP; Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK. anjali.kusumbe@kennedy.ox.ac.uk. |
المصدر: | Science advances [Sci Adv] 2021 Feb 03; Vol. 7 (6). Date of Electronic Publication: 2021 Feb 03 (Print Publication: 2021). |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: PubMed not MEDLINE; MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, DC : American Association for the Advancement of Science, [2015]- |
مستخلص: | Blood vessels provide supportive microenvironments for maintaining tissue functions. Age-associated vascular changes and their relation to tissue aging and pathology are poorly understood. Here, we perform 3D imaging of young and aging vascular beds. Multiple organs in mice and humans demonstrate an age-dependent decline in vessel density and pericyte numbers, while highly remodeling tissues such as skin preserve the vasculature. Vascular attrition precedes the appearance of cellular hallmarks of aging such as senescence. Endothelial VEGFR2 loss-of-function mice demonstrate that vascular perturbations are sufficient to stimulate cellular changes coupled with aging. Age-associated tissue-specific molecular changes in the endothelium drive vascular loss and dictate pericyte to fibroblast differentiation. Lineage tracing of perivascular cells with inducible PDGFRβ and NG2 Cre mouse lines demonstrated that increased pericyte to fibroblast differentiation distinguishes injury-induced organ fibrosis and zymosan-induced arthritis. To spur further discoveries, we provide a freely available resource with 3D vascular and tissue maps. (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).) |
References: | Front Immunol. 2012 Sep 12;3:283. (PMID: 22988448) Best Pract Res Clin Rheumatol. 2014 Aug;28(4):565-76. (PMID: 25481550) Nat Med. 2014 Aug;20(8):870-80. (PMID: 25100532) Cell. 2018 Feb 8;172(4):841-856.e16. (PMID: 29395328) Cell Stem Cell. 2008 Sep 11;3(3):301-13. (PMID: 18786417) Cell. 2007 Jul 27;130(2):223-33. (PMID: 17662938) Open Biol. 2019 Oct 31;9(10):190144. (PMID: 31575330) Cell. 2013 Jan 17;152(1-2):340-51. (PMID: 23332765) Nature. 2016 Apr 21;532(7599):323-8. (PMID: 27074509) Cold Spring Harb Perspect Med. 2015 Jan 05;5(1):a023267. (PMID: 25561722) Bioinformatics. 2015 Jan 15;31(2):166-9. (PMID: 25260700) Nature. 2014 Aug 14;512(7513):198-202. (PMID: 25079315) Am J Respir Crit Care Med. 2013 Oct 1;188(7):820-30. (PMID: 23924232) Aging Dis. 2012 Jun;3(3):280-90. (PMID: 22724086) Nat Protoc. 2009;4(8):1184-91. (PMID: 19617889) J Anat. 2008 Jul;213(1):5-25. (PMID: 18638067) Elife. 2018 May 11;7:. (PMID: 29749927) Cell. 2020 Feb 20;180(4):764-779.e20. (PMID: 32059779) Biochimie. 2002 Feb-Mar;84(2-3):131-41. (PMID: 12022944) Cell. 2013 Jun 6;153(6):1194-217. (PMID: 23746838) Sci Rep. 2019 Oct 21;9(1):15022. (PMID: 31636306) Ageing Res Rev. 2009 Oct;8(4):339-48. (PMID: 19576300) Cell. 2012 Jan 20;148(1-2):33-45. (PMID: 22265400) Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6848-6857. (PMID: 30872480) Arthritis Res. 2000;2(5):361-7. (PMID: 11094449) Front Immunol. 2013 Jan 14;3:416. (PMID: 23335923) Genome Biol. 2014;15(12):550. (PMID: 25516281) Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10587-92. (PMID: 16027358) Front Endocrinol (Lausanne). 2018 May 25;9:258. (PMID: 29887832) Cancer Cell. 2018 Mar 12;33(3):463-479.e10. (PMID: 29455927) Nat Rev Mol Cell Biol. 2019 May;20(5):303-320. (PMID: 30745579) Nature. 2014 May 22;509(7501):439-46. (PMID: 24848057) Front Immunol. 2018 Apr 09;9:586. (PMID: 29686666) BMC Bioinformatics. 2009 May 27;10:161. (PMID: 19473525) FASEB J. 2019 Jul;33(7):7929-7941. (PMID: 30917010) Nature. 2014 Mar 20;507(7492):323-328. (PMID: 24646994) Clin Biochem Rev. 2017 Nov;38(3):131-142. (PMID: 29332977) Age (Dordr). 2014 Feb;36(1):313-51. (PMID: 23877171) Aging (Albany NY). 2016 Jan;8(1):3-11. (PMID: 26805432) Bioinformatics. 2010 Jan 1;26(1):139-40. (PMID: 19910308) Am J Respir Crit Care Med. 2005 Apr 15;171(8):899-907. (PMID: 15618458) Nat Methods. 2012 Feb 28;9(3):245-53. (PMID: 22373911) Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1467-77. (PMID: 11893584) JCI Insight. 2019 Jul 11;4(13):. (PMID: 31292293) Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5618-27. (PMID: 27608497) Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: 23104886) Cell Stem Cell. 2015 Jan 8;16(1):51-66. (PMID: 25465115) Biomed Pharmacother. 2018 Jun;102:175-184. (PMID: 29554596) Science. 2017 Aug 25;357(6353):. (PMID: 28775214) Surg Today. 2018 Jan;48(1):110-118. (PMID: 28702871) Front Cell Dev Biol. 2019 Apr 10;7:49. (PMID: 31024911) Nature. 2016 Apr 21;532(7599):380-4. (PMID: 27074508) Nature. 2016 Jan 21;529(7586):316-25. (PMID: 26791722) Eur Respir J. 2014 Nov;44(5):1332-52. (PMID: 25323246) Nature. 2014 Mar 20;507(7492):376-380. (PMID: 24647000) Development. 2011 Sep;138(18):3865-78. (PMID: 21862553) Front Immunol. 2013 Oct 07;4:316. (PMID: 24109481) BMC Cell Biol. 2017 Jan 23;18(1):10. (PMID: 28114883) Nat Rev Mol Cell Biol. 2014 Jan;15(1):19-33. (PMID: 24326621) |
معلومات مُعتمدة: | MC_UP_1605/1 United Kingdom MRC_ Medical Research Council; MR/P02209X/1 United Kingdom MRC_ Medical Research Council; 202300/Z/16/Z United Kingdom WT_ Wellcome Trust; MC_U120085810 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust; 28647 United Kingdom CRUK_ Cancer Research UK |
تواريخ الأحداث: | Date Created: 20210204 Latest Revision: 20240210 |
رمز التحديث: | 20240210 |
مُعرف محوري في PubMed: | PMC7857692 |
DOI: | 10.1126/sciadv.abd7819 |
PMID: | 33536212 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2375-2548 |
---|---|
DOI: | 10.1126/sciadv.abd7819 |